한국 60세 이상 노인에서 사구체여과율과 악력의 연관성: 2016–2018년 국민건강영양조사

초록

Background: This study aimed to investigate the relationship between estimated glomerular filtration rate (eGFR [mL/min per 1.73 m2]) measuredusing modification of diet in renal disease equation and hand-grip strength (HGS [kg]) in patients ≥60 years of age in South Korea. Methods: Our analysis involved 5,165 individuals from the Korea National Health and Nutrition Examination Survey 2016 to 2018. The participants wereaged ≥60 years, and their HGS and serum creatinine levels were measured. Participants diagnosed with cancer were excluded. The participants werecategorized according to their eGFR: subgroup 1, eGFR≥90; subgroup 2, 60≤eGFR<90; subgroup 3, 45≤eGFR<60; and subgroup 4, eGFR<45. Theparticipants were also categorized into the stronger and weaker HGS groups based on their average HGS. Data were analyzed using Pearson’s chisquared test and logistic regression analysis. Results: After correcting all confounding variable, decreased kidney function was associated with increasing odd ratios for weak HGS in femaleparticipant (model 3, P for trend=0.043). Additionally, subgroup 4 (eGFR <45 mL/min per 1.73 m2) showed that the odd ratio for weak HSG was4.496 (95% CI, 1.422–14.211; P for trend=0.043), when compared to subgroup 1 (eGFR ≥90 mL/min per 1.73 m2) and the stronger HGS group infemale participants; however, it was not statistically significant in male participants. Conclusion: Among the elderly (≥60 years) in South Korean, female patients with an eGFR <45 mL/min per 1.73 m2exhibit reduced HGS. Futureresearch should focus on clarifying the relationship between eGFR and HGS.

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