스티렌(Styrene)과 Toluene diisocyanate (TDI)에 의한 직업성 천식 1예

초록

Styrene, a common solvent and volatile organic compound (VOC), is widely used in the factories of plastics, resins, insulators, coatings, and paints. While toluene diisocyanate (TDI) is a well-known causative agent of asthma, styrene has been rarely reported to cause occupational asthma (OA). We report a 50-year-old repairman with OA due to both styrene and TDI in whose job was filling cracks and flattening the surface of vehicles with styrene-containing plaster`s putty, followed by spray painting. He suffered from cough, dyspnea durings the work with putty. He presented with a 2-year history of asthma and allergic rhinitis. The level of serum total IgE and sputum eosinophils were 2,878 IU/L and 63%, respectively. The methacholine challenge test was positive (PC20 0.59 mg/mL). The bronchoprovacation tests with TDI and styrene showed early and dual responses, respectively. Currently, he is in well-controlled state with the use of a combination of inhaled corticosteroid and long acting β2-agonist after the avoidance of the causative agents. (Korean J Asthma Allergy Clin Immunol 2007;27:70-73)

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