백서 두개골 결손부의 골재생에 fibrin glue가 미치는 영향에 관한 실험적 연구

초록

Fibrin glue is composed of fibrinogen and thrombin and used in various regions for multiple use. Basic principle is that thrombin converts fibrinogen to fibrin in the presence of Ca2+. The structure of fibrin is loose at the beginning, but after about 5 minutes a tight structure is formed under the influence of factor Ⅷ which change fibrin monomer into fibrin polymer. Fibrin glue is used for tissue adhesive, suture, local hemostasis, wound healing, closure of subdural space. Fibrin adhesive has been used in oral and maxillofacial surgery for hemostasis after tooth extraction in patients with coagulation disorders, skin graft fixation, reattachment of periodontal flaps, in combination with autogenous bone chips to fill the bony cavities following cyst removal, and for securing the hydroxyapatite granules for maxillary alveolar ridge augmentation. This study is designed for researching influence of fibrin glue during healing phase after making artificial bone defect.

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