An efficient synthesis of fluoro- neplanocin A analogs using electrophilic fluorination and palladium- catalyzed dehydrosilylation

초록

Neplanocin A analogs have attracted attention in the fields of biological and medicinal chemistry due to their potent and broad-spectrum antiviral and antitumor activities. To further explore their potential as therapeutic agents, an alternative and efficient synthesis of fluoro-neplanocin A analogs has been developed by employing stereoselective electrophilic fluorination and palladium-catalyzed dehydrosilylation as key steps. With respect to previous syntheses, the present synthetic methodology provides easy access to key intermediates that could contribute to expanding further the structure-activity relationship studies of neplanocin A analogs.

키워드