Association of N-terminal proB-type Natriuretic Peptide (NT-proBNP) with airflow limitation and exacerbation in COPD

초록

Background and Aims N-terminal pro-B-type natriuretic peptide (NT-proBNP) is a diagnostic and prognostic marker for heart failure. We examined the association between the level of NT-proBNP with pulmonary function and exacerbation in chronic obstructive pulmonary disease (COPD). Methods We performed a retrospective cohort study of 891 COPD patients without previous history of myocardial infarction or heart failure from a multicentered cohort study, The Korea COPD Subgroup Study (KOCOSS), from 2012 to 2019 in South Korea. We analyzed the relationship between serum NT-proBNP and clinical outcomes of pulmonary functions and exacerbations. Results Serum NT-proBNP had a negative correlation with FVC (% predicted, r=-0.094,p=0.006) and DLCO (% predicted, r=-0.142, p210 (pg/ml/ml) and low FEV1 (% predicted) predicted severe exacerbation of COPD (p=0.019) and p210(pg/ml/ml), was predictive of overall COPD exacerbation. Conclusion Serum NT-proBNP correlates with airflow limitation, DLCO and RV/TLC. In patients who are not diagnosed with heart failure, severe exacerbations of COPD, not moderate, is predicted by serum NT-proBNP>210(pg/ml/ml) and FEV1(% predicted).