흰쥐의 갑상인두근과 윤상인두근에서 myosin heavy chain mRNA 아형의 정량적 분석

초록

Background and Objectives：The inferior pharyngeal constrictor muscle (IPC), which consists of the thyropharyngeus (TP) and cricopharyngeus (CP) muscles, plays an important role during deglutition, but their function is different when analysed by radiographic, manometric and electromyographic studies. Materials：The purpose of this study is to quantify the expression levels of MHC mRNA isoforms (2B, 2X, 2A, 2L, b-cardiac, neonatal and embryonic) in thyropharyngeus and cricopharyngeus muscles of rats using the competitive PCR. Results：The thyropharyngeus muscle was mainly consisted of three fast-twitching MHC isoforms, mostly 2X isoform (85.2%). On the other hand, the cricopharyngeus muscle contained two-third of fast-twitching isoforms (65.1%) and one-third of neonatal MHC (34.9%). Conclusions：The thyropharyngeus muscle could be characterized as a fast-twitching muscle and the cricopharyngeus muscle is probably considered as a sarcomeric regenerating muscle that is caused by frequent mechanical damage during deglutition.

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