Clinical Characteristics of Multiple Sclerosis, Neuromyelitis Optica Spectrum Disorders and MOG Associated Diseases in Korea; Analysis of 302 Patients in the National Research Network Registry

초록

Background: A new registration system for Korean CNS demyelinating diseases has been developed since 2020. Objective:.Here we described the clinical features of MS, NMOSD, and MOGAD in Korea based on an expanded clinical registry. Methods: We collected clinical data using an internet based clinical research and trial management system(iCReaT). We compared baseline characteristics in the patients with MS, NMOSD, and MOGAD, and analyzed the risk of relapses. Results: Total 302 patients were registered from May 2020 to July 2022. The proportion of MS, seropositive NMOSD(SP-NMOSD), and MOGAD was 33.2%, 21.9%, and 11.6%, respectively. Disease duration was shorter in MOGAD than MS or SP-NMOSD(p=0.009). ARR and baseline EDSS were lower in MS than in SP-NMOSD or MOGAD(p=0.093, p 60 years)(adjusted HR 0.09 95% CI 0.01-0.97), and higher with elevated CSF protein(adjusted HR 5.21, 95% CI 1.47-18.54). Conclusion: Here we described the distinctive clinical features of MS, NMOSD, and MOGAD based on the newly expanded registry system in Korea. It was found that elevated CSF protein were associated with higher risk of relapse in these diseases.