TNF-alpha-308G > A polymorphism is associated with suicide attempts in major depressive disorder
DC Field | Value | Language |
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dc.contributor.author | Kim, Yong-Ku | - |
dc.contributor.author | Hong, Jin-Pyo | - |
dc.contributor.author | Hwang, Jung-A. | - |
dc.contributor.author | Lee, Heon-Jeong | - |
dc.contributor.author | Yoon, Ho-Kyoung | - |
dc.contributor.author | Lee, Bun-Hee | - |
dc.contributor.author | Jung, Han-Yong | - |
dc.contributor.author | Hahn, Sang-Woo | - |
dc.contributor.author | Na, Kyoung-Sae | - |
dc.date.available | 2020-11-02T20:44:13Z | - |
dc.date.issued | 2013-09-05 | - |
dc.identifier.issn | 0165-0327 | - |
dc.identifier.issn | 1573-2517 | - |
dc.identifier.uri | https://scholarworks.korea.ac.kr/kumedicine/handle/2020.sw.kumedicine/10351 | - |
dc.description.abstract | Background: Despite the substantial role of the cytokine network in depression and suicide, few studies have investigated the role of genetic polymorphisms of pro- and anti-inflammatory cytokines in suicide in major depressive disorder (MDD). The aim of this study was to investigate whether tumor necrosis factor alpha (TNF-alpha) -308G>A, interferon-gamma (IFN-gamma) +874A>T, and inlerleukin-10 (IL-10) -1082A>G are associated with increased risk for suicide attempts in MDD. Methods: Among patients with MDD, 204 patients who had attempted suicide and 97 control patients who had not attempted suicide were recruited. A chi-square Lest was used to identify a possible risk genotype or allele type for suicide. A subsequent multivariate logistic regression analysis was conducted to investigate the influence of a risk genotype or allele type adjusted for other environmental factors. The lethality of the suicide attempt was also tested between genotype and allele types among suicidal patients with MDD. Results: The GG genotype of the TNF-alpha -308G>A polymorphism was found to significantly increase risk for suicide attempt (adjusted OR=2.630, 95% CI=1.206 to 5.734). IFN-gamma +874A>T and IL-10 -1082A>G were not associated with risk for suicide. Lethality of the suicide attempt was not associated with any of the three cytokine genotypes or allele types. Limitations: Limitations include a relatively small sample size and a cross-sectional design. Conclusions: TNF-alpha -308G>A polymorphism is an independent risk factor for suicide attempts in MDD. Future studies should clarify the neural mechanisms by which the GG genotype of TNF-alpha -308G>A influences suicide in MDD. (C) 2013 Elsevier B.V. All rights reserved. | - |
dc.format.extent | 5 | - |
dc.language | 영어 | - |
dc.language.iso | ENG | - |
dc.publisher | ELSEVIER SCIENCE BV | - |
dc.title | TNF-alpha-308G > A polymorphism is associated with suicide attempts in major depressive disorder | - |
dc.type | Article | - |
dc.publisher.location | 네델란드 | - |
dc.identifier.doi | 10.1016/j.jad.2013.03.019 | - |
dc.identifier.scopusid | 2-s2.0-84882925540 | - |
dc.identifier.wosid | 000323563300074 | - |
dc.identifier.bibliographicCitation | JOURNAL OF AFFECTIVE DISORDERS, v.150, no.2, pp 668 - 672 | - |
dc.citation.title | JOURNAL OF AFFECTIVE DISORDERS | - |
dc.citation.volume | 150 | - |
dc.citation.number | 2 | - |
dc.citation.startPage | 668 | - |
dc.citation.endPage | 672 | - |
dc.type.docType | Article | - |
dc.description.isOpenAccess | N | - |
dc.description.journalRegisteredClass | sci | - |
dc.description.journalRegisteredClass | scie | - |
dc.description.journalRegisteredClass | ssci | - |
dc.description.journalRegisteredClass | scopus | - |
dc.relation.journalResearchArea | Neurosciences & Neurology | - |
dc.relation.journalResearchArea | Psychiatry | - |
dc.relation.journalWebOfScienceCategory | Clinical Neurology | - |
dc.relation.journalWebOfScienceCategory | Psychiatry | - |
dc.subject.keywordPlus | NECROSIS-FACTOR-ALPHA | - |
dc.subject.keywordPlus | PROMOTER POLYMORPHISM | - |
dc.subject.keywordPlus | CYTOKINE LEVELS | - |
dc.subject.keywordPlus | RATING SCALE | - |
dc.subject.keywordPlus | BEHAVIOR | - |
dc.subject.keywordPlus | GENE | - |
dc.subject.keywordPlus | TNF | - |
dc.subject.keywordPlus | INFLAMMATION | - |
dc.subject.keywordPlus | DISEASES | - |
dc.subject.keywordPlus | ANXIETY | - |
dc.subject.keywordAuthor | Tumor necrosis factor-alpha | - |
dc.subject.keywordAuthor | Interferon gamma | - |
dc.subject.keywordAuthor | Interleukin-10 | - |
dc.subject.keywordAuthor | Suicide | - |
dc.subject.keywordAuthor | Depression | - |
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