Role of Interleukin 28B-related Gene Polymorphisms in Chronic Hepatitis C and the Response to Antiviral Therapy in Koreans
DC Field | Value | Language |
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dc.contributor.author | Jung, Young Kul | - |
dc.contributor.author | Kim, Ji Hoon | - |
dc.contributor.author | Ahn, Sung-Min | - |
dc.contributor.author | Yang, Jae Won | - |
dc.contributor.author | Park, Sang Jin | - |
dc.contributor.author | Kim, Jong Woo | - |
dc.contributor.author | Yeon, Jong Eun | - |
dc.contributor.author | Kwon, Oh Sang | - |
dc.contributor.author | Kim, Yun Soo | - |
dc.contributor.author | Choi, Duck Joo | - |
dc.contributor.author | Kim, Ju Hyun | - |
dc.contributor.author | Byun, Kwan Soo | - |
dc.date.available | 2020-11-02T20:45:48Z | - |
dc.date.issued | 2013-08 | - |
dc.identifier.issn | 0192-0790 | - |
dc.identifier.issn | 1539-2031 | - |
dc.identifier.uri | https://scholarworks.korea.ac.kr/kumedicine/handle/2020.sw.kumedicine/10501 | - |
dc.description.abstract | Background: Genetic variations in interleukin 28B (IL28B) have been strongly associated with a sustained virological response (SVR) in European and African-American patients. Genetic variation of IL28B was investigated in healthy controls and chronic hepatitis C (CHC) patients, and the treatment response in the CHC patients was analyzed according to IL28B polymorphism in the Korean population. Methods: IL28B polymorphisms (rs12979860 and rs8099917) were studied in 200 healthy controls and in 167 CHC patients who were treated with peginterferon-α and ribavirin. Results: The prevalence of rs12979860 in healthy controls is as follows: the CC-genotype was 88.5%, the CT-genotype was 11.5%, and the TT-genotype was not found. The prevalence of rs8099917 in healthy controls is as follows: the TT-genotype was 89.5%, the TG-genotype was 10.5%, and the GG-genotype was not found. The CC-genotype of rs12979860 and the TT-genotype of rs8099917 were found to be closely related (linkage disequilibrium; D′=1.0, χ2=0.9082). In 106 CHC patients treated with peginterferon and ribavirin, the SVR was 67.2% (n=58) for 1b, 91.6% (n=47) for 2a. In hepatitis C virus (HCV) genotype 1b with respect to rs12979860, the SVR in CC-genotype was 72.9% and that in CT-genotype was 40.0%. On investigating predictive factors for SVR, pretreatment low-HCV RNA levels, HCV genotype non-1, early virological response, and also the IL28B CC-genotype for rs12979860 were good indicators of an SVR. Conclusions: In Korea, genetic variation of IL28B is different from that in western countries in view of high prevalence of rs12979860 CC-genotype. It seems likely that a high SVR in Korean patients with genotype 1 CHC patients is due to the genetic polymorphism in IL28B. | - |
dc.format.extent | 7 | - |
dc.language | 영어 | - |
dc.language.iso | ENG | - |
dc.publisher | Lippincott Williams & Wilkins Ltd. | - |
dc.title | Role of Interleukin 28B-related Gene Polymorphisms in Chronic Hepatitis C and the Response to Antiviral Therapy in Koreans | - |
dc.type | Article | - |
dc.publisher.location | 미국 | - |
dc.identifier.doi | 10.1097/MCG.0b013e3182896abf | - |
dc.identifier.scopusid | 2-s2.0-84880750646 | - |
dc.identifier.wosid | 000323228000013 | - |
dc.identifier.bibliographicCitation | Journal of Clinical Gastroenterology, v.47, no.7, pp 644 - 650 | - |
dc.citation.title | Journal of Clinical Gastroenterology | - |
dc.citation.volume | 47 | - |
dc.citation.number | 7 | - |
dc.citation.startPage | 644 | - |
dc.citation.endPage | 650 | - |
dc.type.docType | Article | - |
dc.description.isOpenAccess | N | - |
dc.description.journalRegisteredClass | sci | - |
dc.description.journalRegisteredClass | scie | - |
dc.description.journalRegisteredClass | scopus | - |
dc.relation.journalResearchArea | Gastroenterology & Hepatology | - |
dc.relation.journalWebOfScienceCategory | Gastroenterology & Hepatology | - |
dc.subject.keywordPlus | B-VIRUS INFECTION | - |
dc.subject.keywordPlus | COMBINATION THERAPY | - |
dc.subject.keywordPlus | NATURAL-HISTORY | - |
dc.subject.keywordPlus | PLUS RIBAVIRIN | - |
dc.subject.keywordPlus | IL28B | - |
dc.subject.keywordPlus | PEGINTERFERON | - |
dc.subject.keywordPlus | ASSOCIATION | - |
dc.subject.keywordPlus | FREQUENCIES | - |
dc.subject.keywordPlus | CLEARANCE | - |
dc.subject.keywordPlus | AMERICAN | - |
dc.subject.keywordAuthor | IL28B | - |
dc.subject.keywordAuthor | gene polymorphism | - |
dc.subject.keywordAuthor | hepatitis C virus | - |
dc.subject.keywordAuthor | antiviral therapy | - |
dc.subject.keywordAuthor | Korean | - |
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