Role of prostaglandin D2 in mast cell activation-induced sensitization of esophageal vagal afferents
DC Field | Value | Language |
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dc.contributor.author | Zhang S. | - |
dc.contributor.author | Grabauskas G. | - |
dc.contributor.author | Wu X. | - |
dc.contributor.author | Joo M.K. | - |
dc.contributor.author | Heldsinger A. | - |
dc.contributor.author | Song I. | - |
dc.contributor.author | Owyang C. | - |
dc.contributor.author | Yu S. | - |
dc.date.available | 2020-11-02T22:43:36Z | - |
dc.date.issued | 2013 | - |
dc.identifier.issn | 0193-1857 | - |
dc.identifier.issn | 1522-1547 | - |
dc.identifier.uri | https://scholarworks.korea.ac.kr/kumedicine/handle/2020.sw.kumedicine/11365 | - |
dc.description.abstract | Sensitization of esophageal afferents plays an important role in esophageal nociception, but the mechanism is less clear. Our previous studies demonstrated that mast cell (MC) activation releases the preformed mediators histamine and tryptase, which play important roles in sensitization of esophageal vagal nociceptive C fibers. PGD2 is a lipid mediator released by activated MCs. Whether PGD2 plays a role in this sensitization process has yet to be determined. Expression of the PGD2 DP1 and DP2 receptors in nodose ganglion neurons was determined by immunofluorescence staining, Western blotting, and RT-PCR. Extracellular recordings were performed in ex vivo esophageal-vagal preparations. Action potentials evoked by esophageal distension were compared before and after perfusion of PGD2, DP1 and DP2 receptor agonists, and MC activation, with or without pretreatment with antagonists. The effect of PGD2 on 1,1′-dioctadecyl-3,3,3′,3′-tetramethylindocarbocyanine perchlorate (DiI)-labeled esophageal nodose neurons was determined by patch-clamp recording. Our results demonstrate that DP1 and DP2 receptor mRNA and protein were expressed mainly in small- and medium-diameter neurons in nodose ganglia. PGD2 significantly increased esophageal distension-evoked action potential discharges in esophageal nodose C fibers. The DP1 receptor agonist BW 245C mimicked this effect. PGD2 directly sensitized DiI-labeled esophageal nodose neurons by decreasing the action potential threshold. Pretreatment with the DP1 receptor antagonist BW A868C significantly inhibited PGD2 perfusion- or MC activation-induced increases in esophageal distension-evoked action potential discharges in esophageal nodose C fibers. In conclusion, PGD2 plays an important role in MC activation-induced sensitization of esophageal nodose C fibers. This adds a novel mechanism of visceral afferent sensitization. © 2013 the American Physiological Society. | - |
dc.language | 영어 | - |
dc.language.iso | ENG | - |
dc.title | Role of prostaglandin D2 in mast cell activation-induced sensitization of esophageal vagal afferents | - |
dc.type | Article | - |
dc.publisher.location | 미국 | - |
dc.identifier.doi | 10.1152/ajpgi.00448.2012 | - |
dc.identifier.scopusid | 2-s2.0-84878660890 | - |
dc.identifier.bibliographicCitation | American Journal of Physiology - Gastrointestinal and Liver Physiology, v.304, no.10, pp G908 - G916 | - |
dc.citation.title | American Journal of Physiology - Gastrointestinal and Liver Physiology | - |
dc.citation.volume | 304 | - |
dc.citation.number | 10 | - |
dc.citation.startPage | G908 | - |
dc.citation.endPage | G916 | - |
dc.type.docType | Article | - |
dc.description.isOpenAccess | N | - |
dc.description.journalRegisteredClass | sci | - |
dc.description.journalRegisteredClass | scie | - |
dc.description.journalRegisteredClass | scopus | - |
dc.subject.keywordPlus | 1,1' dioctadecyl 3,3,3',3' tetramethylindocarbocyanine | - |
dc.subject.keywordPlus | messenger RNA | - |
dc.subject.keywordPlus | prostaglandin D2 | - |
dc.subject.keywordPlus | 3,3' dioctadecylindocarbocyanine | - |
dc.subject.keywordPlus | 3,3'-dioctadecylindocarbocyanine | - |
dc.subject.keywordPlus | carbocyanine | - |
dc.subject.keywordPlus | immunoglobulin receptor | - |
dc.subject.keywordPlus | prostaglandin D2 | - |
dc.subject.keywordPlus | prostaglandin D2 receptor | - |
dc.subject.keywordPlus | prostaglandin receptor | - |
dc.subject.keywordPlus | action potential | - |
dc.subject.keywordPlus | animal experiment | - |
dc.subject.keywordPlus | animal model | - |
dc.subject.keywordPlus | article | - |
dc.subject.keywordPlus | controlled study | - |
dc.subject.keywordPlus | esophagus | - |
dc.subject.keywordPlus | evoked response | - |
dc.subject.keywordPlus | ex vivo study | - |
dc.subject.keywordPlus | guinea pig | - |
dc.subject.keywordPlus | immunofluorescence | - |
dc.subject.keywordPlus | inhibition kinetics | - |
dc.subject.keywordPlus | male | - |
dc.subject.keywordPlus | mast cell | - |
dc.subject.keywordPlus | nerve ending | - |
dc.subject.keywordPlus | nodose ganglion | - |
dc.subject.keywordPlus | nonhuman | - |
dc.subject.keywordPlus | patch clamp | - |
dc.subject.keywordPlus | priority journal | - |
dc.subject.keywordPlus | protein expression | - |
dc.subject.keywordPlus | protein function | - |
dc.subject.keywordPlus | quantitative analysis | - |
dc.subject.keywordPlus | reverse transcription polymerase chain reaction | - |
dc.subject.keywordPlus | sensory nerve | - |
dc.subject.keywordPlus | spinal ganglion | - |
dc.subject.keywordPlus | Western blotting | - |
dc.subject.keywordPlus | animal | - |
dc.subject.keywordPlus | c fiber | - |
dc.subject.keywordPlus | cytology | - |
dc.subject.keywordPlus | drug effect | - |
dc.subject.keywordPlus | drug potentiation | - |
dc.subject.keywordPlus | fluorescent antibody technique | - |
dc.subject.keywordPlus | innervation | - |
dc.subject.keywordPlus | metabolism | - |
dc.subject.keywordPlus | nerve fiber | - |
dc.subject.keywordPlus | nonmyelinated nerve | - |
dc.subject.keywordPlus | PGD2 | - |
dc.subject.keywordPlus | physiology | - |
dc.subject.keywordPlus | real time polymerase chain reaction | - |
dc.subject.keywordPlus | sensory nerve cell | - |
dc.subject.keywordPlus | statistical analysis | - |
dc.subject.keywordPlus | stimulation | - |
dc.subject.keywordPlus | vagal afferent | - |
dc.subject.keywordPlus | vagus nerve | - |
dc.subject.keywordPlus | C fiber | - |
dc.subject.keywordPlus | esophagus | - |
dc.subject.keywordPlus | mast cell | - |
dc.subject.keywordPlus | PGD2 | - |
dc.subject.keywordPlus | vagal afferent | - |
dc.subject.keywordPlus | Action Potentials | - |
dc.subject.keywordPlus | Animals | - |
dc.subject.keywordPlus | Blotting, Western | - |
dc.subject.keywordPlus | Carbocyanines | - |
dc.subject.keywordPlus | Data Interpretation, Statistical | - |
dc.subject.keywordPlus | Esophagus | - |
dc.subject.keywordPlus | Fluorescent Antibody Technique | - |
dc.subject.keywordPlus | Guinea Pigs | - |
dc.subject.keywordPlus | Male | - |
dc.subject.keywordPlus | Mast Cells | - |
dc.subject.keywordPlus | Nerve Fibers | - |
dc.subject.keywordPlus | Nerve Fibers, Unmyelinated | - |
dc.subject.keywordPlus | Neurons, Afferent | - |
dc.subject.keywordPlus | Nodose Ganglion | - |
dc.subject.keywordPlus | Patch-Clamp Techniques | - |
dc.subject.keywordPlus | Physical Stimulation | - |
dc.subject.keywordPlus | Prostaglandin D2 | - |
dc.subject.keywordPlus | Real-Time Polymerase Chain Reaction | - |
dc.subject.keywordPlus | Receptors, Immunologic | - |
dc.subject.keywordPlus | Receptors, Prostaglandin | - |
dc.subject.keywordPlus | Vagus Nerve | - |
dc.subject.keywordAuthor | C fiber | - |
dc.subject.keywordAuthor | Esophagus | - |
dc.subject.keywordAuthor | Mast cell | - |
dc.subject.keywordAuthor | PGD2 | - |
dc.subject.keywordAuthor | Vagal afferent | - |
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