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Prognosis of hepatitis B-related liver cirrhosis in the era of oral nucleos(t)ide analog antiviral agents

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dc.contributor.authorKim, Chang Ha-
dc.contributor.authorUm, Soon Ho-
dc.contributor.authorSeo, Yeon Seok-
dc.contributor.authorJung, Jin Yong-
dc.contributor.authorKim, Jin Dong-
dc.contributor.authorYim, Hyung Joon-
dc.contributor.authorKeum, Bora-
dc.contributor.authorKim, Yong Sik-
dc.contributor.authorJeen, Yoon Tae-
dc.contributor.authorLee, Hong Sik-
dc.contributor.authorChun, Hoon Jai-
dc.contributor.authorKim, Chang Duck-
dc.contributor.authorRyu, Ho Sang-
dc.date.available2020-11-02T22:47:24Z-
dc.date.issued2012-10-
dc.identifier.issn0815-9319-
dc.identifier.issn1440-1746-
dc.identifier.urihttps://scholarworks.korea.ac.kr/kumedicine/handle/2020.sw.kumedicine/11684-
dc.description.abstractBackground and Aim: We investigated long-term outcomes and prognostic factors in patients with hepatitis B virus (HBV)-related liver cirrhosis in the era of oral nucleos(t)ide analog antiviral agents. Methods: Between January 1999 and February 2009, a total of 240 consecutive patients who had HBV-related cirrhosis without malignancy were treated with lamivudine and second line nucleos(t)ide analogs. The group of historical controls consisted of 481 consecutive patients with HBV-related cirrhosis who were managed without any antiviral treatment prior to 1999. Results: In 78% of the patients who received antiviral treatment, sustained viral suppression (serum HBV DNA < 105 copies/mL) was achieved during a mean follow-up period of 46 months. The occurrences of death, hepatic decompensation, and hepatocellular carcinoma (HCC) were less frequent in the treated cohort than in untreated historical controls, with the 5-year cumulative incidences being 19.4% versus 43.9% (log-rank P < 0.001), 15.4% versus 45.4% (P = 0.001), and 13.8% versus 23.4% (P = 0.074), respectively. For patients who received antiviral treatment, suboptimal viral suppression (HBV DNA > 105 copies/mL at last follow-up) was an important independent risk factor of death (P < 0.001) and hepatic decompensation (P = 0.019), and was linked to an increased risk of HCC (P = 0.042). Although the ChildPugh grade remained a useful prognostic factor, no significant differences were found between patients with ChildPugh grade B and C cirrhosis at the beginning of antiviral treatment (P = 0.656). Conclusions: Oral antiviral agents have improved the prognosis of patients with HBV-related cirrhosis and affected the prognostic values of factors constituting the ChildPugh system, necessitating a more efficient prognostic system.-
dc.format.extent7-
dc.language영어-
dc.language.isoENG-
dc.publisherWILEY-
dc.titlePrognosis of hepatitis B-related liver cirrhosis in the era of oral nucleos(t)ide analog antiviral agents-
dc.typeArticle-
dc.publisher.location미국-
dc.identifier.doi10.1111/j.1440-1746.2012.07167.x-
dc.identifier.scopusid2-s2.0-84866527210-
dc.identifier.wosid000309070000010-
dc.identifier.bibliographicCitationJOURNAL OF GASTROENTEROLOGY AND HEPATOLOGY, v.27, no.10, pp 1589 - 1595-
dc.citation.titleJOURNAL OF GASTROENTEROLOGY AND HEPATOLOGY-
dc.citation.volume27-
dc.citation.number10-
dc.citation.startPage1589-
dc.citation.endPage1595-
dc.type.docTypeArticle-
dc.description.isOpenAccessN-
dc.description.journalRegisteredClasssci-
dc.description.journalRegisteredClassscie-
dc.description.journalRegisteredClassscopus-
dc.relation.journalResearchAreaGastroenterology & Hepatology-
dc.relation.journalWebOfScienceCategoryGastroenterology & Hepatology-
dc.subject.keywordPlusVIRUS-RELATED CIRRHOSIS-
dc.subject.keywordPlusHEPATOCELLULAR-CARCINOMA-
dc.subject.keywordPlusNATURAL-HISTORY-
dc.subject.keywordPlusCOMPENSATED CIRRHOSIS-
dc.subject.keywordPlusLAMIVUDINE TREATMENT-
dc.subject.keywordPlusSURVIVAL-
dc.subject.keywordPlusINFECTION-
dc.subject.keywordPlusDISEASE-
dc.subject.keywordPlusDECOMPENSATION-
dc.subject.keywordPlusINDICATORS-
dc.subject.keywordAuthorhepatitis B-related liver cirrhosis-
dc.subject.keywordAuthorlamivudine-
dc.subject.keywordAuthororal antiviral agent-
dc.subject.keywordAuthorprognosis-
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Anam Hospital (Department of Gastroenterology and Hepatology, Anam Hospital)
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