Ten-day sequential versus triple therapy for Helicobacterpylori eradication: A prospective, open-label, randomized trial
DC Field | Value | Language |
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dc.contributor.author | Chung J.-W. | - |
dc.contributor.author | Jung Y.K. | - |
dc.contributor.author | Kim Y.J. | - |
dc.contributor.author | Kwon K.A. | - |
dc.contributor.author | Kim J.H. | - |
dc.contributor.author | Lee J.J. | - |
dc.contributor.author | Lee S.M. | - |
dc.contributor.author | Hahm K.B. | - |
dc.contributor.author | Lee S.M. | - |
dc.contributor.author | Jeong J.Y. | - |
dc.contributor.author | Yun S.-C. | - |
dc.date.available | 2020-11-03T01:43:55Z | - |
dc.date.issued | 2012 | - |
dc.identifier.issn | 0815-9319 | - |
dc.identifier.issn | 1440-1746 | - |
dc.identifier.uri | https://scholarworks.korea.ac.kr/kumedicine/handle/2020.sw.kumedicine/12816 | - |
dc.description.abstract | Background and Aim: Increased resistance of Helicobacter pylori to antibiotics has increased the need to develop new first-line treatments for H.pylori. We have prospectively evaluated 10-day sequential versus conventional triple therapy in peptic ulcer patients. Methods: One hundred and fifty-nine patients with peptic ulcer diseases were prospectively randomized to receive 10days of lansoprazole, amoxicillin, and clarithromycin (conventional triple therapy) or 5days of lansoprazole and amoxicillin followed by 5days of lansoprazole, clarithromycin, and metronidazole (sequential therapy). Post-treatment H.pylori status was determined by the 13C-urea breath test. Eradication rates, antibiotic resistance rates by agar dilution method, drug compliance, and side-effects were compared. Results: The intention-to-treat eradication rates were 75.9% (95% CI 66.5-85.3%, 60/79) in the sequential therapy group and 58.7% (95% CI 47.9-69.5%, 47/80) in the conventional triple therapy group (P=0.01), while the per-protocol eradication rates were 86.8% (95% CI 78.7-94.8%, 59/68) and 67.6% (95% CI 56.5-78.7%, 46/68) (P=0.01), respectively. Compliance and side-effects were similar in the two groups. Culture of H.pylori showed that 18.2% were resistant to clarithromycin, 41.9% to metronidazole. Dual resistance to both antibiotics was 9.6%. Conclusions: Although 10-day sequential therapy yielded a higher H.pylori eradication rate than 10-day conventional triple therapy, the sequential therapy protocol did not result in a sufficiently satisfactory eradication rate. This might be related to the higher antibiotics resistance rate especially to dual resistance. More effective regimens are needed to overcome antibiotic resistance in Korea. © 2012 Journal of Gastroenterology and Hepatology Foundation and Wiley P1ublishing Asia Pty Ltd. | - |
dc.format.extent | 6 | - |
dc.language | 영어 | - |
dc.language.iso | ENG | - |
dc.title | Ten-day sequential versus triple therapy for Helicobacterpylori eradication: A prospective, open-label, randomized trial | - |
dc.type | Article | - |
dc.publisher.location | 미국 | - |
dc.identifier.doi | 10.1111/j.1440-1746.2012.07249.x | - |
dc.identifier.scopusid | 2-s2.0-84868124449 | - |
dc.identifier.bibliographicCitation | Journal of Gastroenterology and Hepatology (Australia), v.27, no.11, pp 1675 - 1680 | - |
dc.citation.title | Journal of Gastroenterology and Hepatology (Australia) | - |
dc.citation.volume | 27 | - |
dc.citation.number | 11 | - |
dc.citation.startPage | 1675 | - |
dc.citation.endPage | 1680 | - |
dc.type.docType | Article | - |
dc.description.isOpenAccess | N | - |
dc.description.journalRegisteredClass | sci | - |
dc.description.journalRegisteredClass | scie | - |
dc.description.journalRegisteredClass | scopus | - |
dc.subject.keywordPlus | amoxicillin | - |
dc.subject.keywordPlus | clarithromycin | - |
dc.subject.keywordPlus | lansoprazole | - |
dc.subject.keywordPlus | levofloxacin | - |
dc.subject.keywordPlus | metronidazole | - |
dc.subject.keywordPlus | tetracycline | - |
dc.subject.keywordPlus | abdominal pain | - |
dc.subject.keywordPlus | adult | - |
dc.subject.keywordPlus | agar dilution | - |
dc.subject.keywordPlus | antibiotic resistance | - |
dc.subject.keywordPlus | article | - |
dc.subject.keywordPlus | asthenia | - |
dc.subject.keywordPlus | clinical protocol | - |
dc.subject.keywordPlus | cohort analysis | - |
dc.subject.keywordPlus | controlled study | - |
dc.subject.keywordPlus | diarrhea | - |
dc.subject.keywordPlus | disease control | - |
dc.subject.keywordPlus | drug withdrawal | - |
dc.subject.keywordPlus | duodenum ulcer | - |
dc.subject.keywordPlus | female | - |
dc.subject.keywordPlus | headache | - |
dc.subject.keywordPlus | Helicobacter infection | - |
dc.subject.keywordPlus | human | - |
dc.subject.keywordPlus | intention to treat analysis | - |
dc.subject.keywordPlus | intermethod comparison | - |
dc.subject.keywordPlus | Korea | - |
dc.subject.keywordPlus | major clinical study | - |
dc.subject.keywordPlus | male | - |
dc.subject.keywordPlus | nausea | - |
dc.subject.keywordPlus | nonhuman | - |
dc.subject.keywordPlus | open study | - |
dc.subject.keywordPlus | patient compliance | - |
dc.subject.keywordPlus | patient satisfaction | - |
dc.subject.keywordPlus | priority journal | - |
dc.subject.keywordPlus | prospective study | - |
dc.subject.keywordPlus | randomized controlled trial | - |
dc.subject.keywordPlus | rash | - |
dc.subject.keywordPlus | stomach ulcer | - |
dc.subject.keywordPlus | taste disorder | - |
dc.subject.keywordPlus | treatment duration | - |
dc.subject.keywordPlus | urea breath test | - |
dc.subject.keywordPlus | 2-Pyridinylmethylsulfinylbenzimidazoles | - |
dc.subject.keywordPlus | Adult | - |
dc.subject.keywordPlus | Amoxicillin | - |
dc.subject.keywordPlus | Anti-Bacterial Agents | - |
dc.subject.keywordPlus | Anti-Ulcer Agents | - |
dc.subject.keywordPlus | Breath Tests | - |
dc.subject.keywordPlus | Chi-Square Distribution | - |
dc.subject.keywordPlus | Clarithromycin | - |
dc.subject.keywordPlus | Confidence Intervals | - |
dc.subject.keywordPlus | Drug Administration Schedule | - |
dc.subject.keywordPlus | Drug Resistance, Multiple, Bacterial | - |
dc.subject.keywordPlus | Drug Therapy, Combination | - |
dc.subject.keywordPlus | Female | - |
dc.subject.keywordPlus | Helicobacter Infections | - |
dc.subject.keywordPlus | Helicobacter pylori | - |
dc.subject.keywordPlus | Humans | - |
dc.subject.keywordPlus | Intention to Treat Analysis | - |
dc.subject.keywordPlus | Male | - |
dc.subject.keywordPlus | Metronidazole | - |
dc.subject.keywordPlus | Middle Aged | - |
dc.subject.keywordPlus | Patient Compliance | - |
dc.subject.keywordPlus | Republic of Korea | - |
dc.subject.keywordPlus | Urea | - |
dc.subject.keywordAuthor | Antibiotics resistance | - |
dc.subject.keywordAuthor | Clarithromycin | - |
dc.subject.keywordAuthor | Helicobacter pylori | - |
dc.subject.keywordAuthor | Metronidazole | - |
dc.subject.keywordAuthor | Peptic ulcer disease | - |
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