Paliperidone in the treatment of delirium: results of a prospective open-label pilot trial
DC Field | Value | Language |
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dc.contributor.author | Yoon, Ho-Kyoung | - |
dc.contributor.author | Kim, Yong-Ku | - |
dc.contributor.author | Han, Changsu | - |
dc.contributor.author | Ko, Young-Hoon | - |
dc.contributor.author | Lee, Heon-Jeong | - |
dc.contributor.author | Kwon, Do-Young | - |
dc.contributor.author | Kim, Leen | - |
dc.date.available | 2020-11-03T02:44:32Z | - |
dc.date.issued | 2011-08 | - |
dc.identifier.issn | 0924-2708 | - |
dc.identifier.issn | 1601-5215 | - |
dc.identifier.uri | https://scholarworks.korea.ac.kr/kumedicine/handle/2020.sw.kumedicine/13294 | - |
dc.description.abstract | Objective: Delirium is a life-threatening neuropsychiatric syndrome characterised by disturbances in consciousness, attention, cognition and perception. Antipsychotics are considered the drugs of choice in managing the symptoms of delirium. Paliperidone is a benzisoxazole derivative and the principal active metabolite of risperidone. In this study, we aimed to evaluate the efficacy of paliperidone for the treatment of delirium. Methods: A prospective open-label study of paliperidone for delirium treatment was performed with 6-day follow-up. Fifteen patients who met Diagnostic and Statistical Manual of Mental disorders, Fourth Edition criteria for delirium and had a score of 13 on the Delirium Rating Scale were recruited. The starting dose was 3 mg once a day and the dose was adjusted depending on the status of delirium. Daily assessments of the severity of delirium were evaluated using Memorial Delirium Assessment Scale (MDAS). Results: The mean daily maintenance dose of paliperidone was 3.75 +/- 1.06. The MDAS scores before and after treatment (day 7) were 23.60 +/- 6.31 and 11.33 +/- 5.45 (t = 6.78, p < 0.001), respectively. The intensity of delirium showed a statistically significant reduction in MDAS scores from the first day of treatment. No serious adverse effects were observed, and none of the patients discontinued paliperidone because of adverse effects. Conclusions: This study shows that low-dose paliperidone is effective in reducing behavioural disturbances and symptoms in delirium and is well tolerated in delirious patients. This trial is an open-label study with a small sample size, and further controlled studies will be necessary. | - |
dc.format.extent | 5 | - |
dc.language | 영어 | - |
dc.language.iso | ENG | - |
dc.publisher | CAMBRIDGE UNIV PRESS | - |
dc.title | Paliperidone in the treatment of delirium: results of a prospective open-label pilot trial | - |
dc.type | Article | - |
dc.publisher.location | 미국 | - |
dc.identifier.doi | 10.1111/j.1601-5215.2011.00568.x | - |
dc.identifier.scopusid | 2-s2.0-79960562350 | - |
dc.identifier.wosid | 000292829600007 | - |
dc.identifier.bibliographicCitation | ACTA NEUROPSYCHIATRICA, v.23, no.4, pp 179 - 183 | - |
dc.citation.title | ACTA NEUROPSYCHIATRICA | - |
dc.citation.volume | 23 | - |
dc.citation.number | 4 | - |
dc.citation.startPage | 179 | - |
dc.citation.endPage | 183 | - |
dc.type.docType | Article | - |
dc.description.isOpenAccess | N | - |
dc.description.journalRegisteredClass | scie | - |
dc.description.journalRegisteredClass | scopus | - |
dc.relation.journalResearchArea | Neurosciences & Neurology | - |
dc.relation.journalResearchArea | Psychiatry | - |
dc.relation.journalWebOfScienceCategory | Neurosciences | - |
dc.relation.journalWebOfScienceCategory | Psychiatry | - |
dc.subject.keywordPlus | EXTENDED-RELEASE TABLETS | - |
dc.subject.keywordPlus | ATYPICAL ANTIPSYCHOTICS | - |
dc.subject.keywordPlus | RATING-SCALE | - |
dc.subject.keywordPlus | DOUBLE-BLIND | - |
dc.subject.keywordPlus | RISPERIDONE | - |
dc.subject.keywordPlus | HALOPERIDOL | - |
dc.subject.keywordPlus | DRUGS | - |
dc.subject.keywordAuthor | delirium | - |
dc.subject.keywordAuthor | DRS | - |
dc.subject.keywordAuthor | MDAS | - |
dc.subject.keywordAuthor | paliperidone | - |
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