Phase II study of vinorelbine monotherapy in anthracycline and taxane pre-treated metastatic breast cancer
DC Field | Value | Language |
---|---|---|
dc.contributor.author | Seo, Hee Yeon | - |
dc.contributor.author | Lee, Hyun Joo | - |
dc.contributor.author | Woo, Ok Hee | - |
dc.contributor.author | Park, Kyong Hwa | - |
dc.contributor.author | Woo, Sang Uk | - |
dc.contributor.author | Yang, Dae Sik | - |
dc.contributor.author | Kim, Ae-Ree | - |
dc.contributor.author | Lee, Jae-Bok | - |
dc.contributor.author | Lee, Eun Sook | - |
dc.contributor.author | Kim, Yeul Hong | - |
dc.contributor.author | Kim, Jun Suk | - |
dc.contributor.author | Seo, Jae Hong | - |
dc.date.available | 2020-11-03T03:47:22Z | - |
dc.date.issued | 2011-04 | - |
dc.identifier.issn | 0167-6997 | - |
dc.identifier.issn | 1573-0646 | - |
dc.identifier.uri | https://scholarworks.korea.ac.kr/kumedicine/handle/2020.sw.kumedicine/13600 | - |
dc.description.abstract | We performed a single-institution phase II study to evaluate the efficacy and toxicities of vinorelbine monotherapy in patients previously treated with anthracyclines and taxanes. Vinorelbine was administered at a dose level of 25 mg/m(2) intravenously on days 1, 8, 15 and 22, every four weeks, and responses were assessed after every two cycles of treatment. All of the patients had previously been treated with anthracyclines and taxanes. A total of 26 patients were enrolled in this study between April 2004 and August 2009. The median age of the patients was 47 years (range, 37 to 71 years), and 80.8% had an Eastern Cooperative Oncology Group performance status of 0 or 1. Out of 24 evaluable patients, five partial responses were observed, giving an overall response rate of 20.8%, with a median response duration of 2.8 months. The median time to progression was 3.7 months (range, 0.5 to 22.6 months), and median overall survival duration was 10.4 months (range, 1.3 to 57.6 months). The major toxicities observed were neutropenia, anemia and peripheral neuropathy. Grade 3 or 4 hematologic toxicities included neutropenia in 18 patients (69.2%) and anemia in four patients (15.3%). Grade 1 or 2 peripheral neuropathy was observed in 11 patients (42.3%), however there were no cases of grade 3 or 4 peripheral neuropathy. The results of this study indicate that vinorelbine monotherapy was feasible regimen with manageable toxicities in patients with metastatic breast cancer who were previously exposed to anthracyclines and taxanes. | - |
dc.format.extent | 6 | - |
dc.language | 영어 | - |
dc.language.iso | ENG | - |
dc.publisher | SPRINGER | - |
dc.title | Phase II study of vinorelbine monotherapy in anthracycline and taxane pre-treated metastatic breast cancer | - |
dc.type | Article | - |
dc.publisher.location | 네델란드 | - |
dc.identifier.doi | 10.1007/s10637-009-9357-y | - |
dc.identifier.scopusid | 2-s2.0-79957519270 | - |
dc.identifier.wosid | 000287248100019 | - |
dc.identifier.bibliographicCitation | INVESTIGATIONAL NEW DRUGS, v.29, no.2, pp 360 - 365 | - |
dc.citation.title | INVESTIGATIONAL NEW DRUGS | - |
dc.citation.volume | 29 | - |
dc.citation.number | 2 | - |
dc.citation.startPage | 360 | - |
dc.citation.endPage | 365 | - |
dc.type.docType | Article | - |
dc.description.isOpenAccess | N | - |
dc.description.journalRegisteredClass | sci | - |
dc.description.journalRegisteredClass | scie | - |
dc.description.journalRegisteredClass | scopus | - |
dc.relation.journalResearchArea | Oncology | - |
dc.relation.journalResearchArea | Pharmacology & Pharmacy | - |
dc.relation.journalWebOfScienceCategory | Oncology | - |
dc.relation.journalWebOfScienceCategory | Pharmacology & Pharmacy | - |
dc.subject.keywordPlus | FIRST-LINE | - |
dc.subject.keywordPlus | INTRAVENOUS VINORELBINE | - |
dc.subject.keywordPlus | SINGLE-AGENT | - |
dc.subject.keywordPlus | CHEMOTHERAPY | - |
dc.subject.keywordPlus | PACLITAXEL | - |
dc.subject.keywordPlus | GUIDELINES | - |
dc.subject.keywordPlus | CARCINOMA | - |
dc.subject.keywordPlus | NAVELBINE | - |
dc.subject.keywordPlus | TRIAL | - |
dc.subject.keywordAuthor | Metastatic breast cancer | - |
dc.subject.keywordAuthor | Anthracyclines | - |
dc.subject.keywordAuthor | Taxanes | - |
dc.subject.keywordAuthor | Vinorelbine | - |
dc.subject.keywordAuthor | Chemotherapy | - |
Items in ScholarWorks are protected by copyright, with all rights reserved, unless otherwise indicated.
73, Goryeodae-ro, Seongbuk-gu, Seoul, Republic of Korea (02841)82-2-2286-1265
COPYRIGHT 2020 KOREA UNIVERSITY MEDICAL LIBRARY ALL RIGHTS RESERVED.
Certain data included herein are derived from the © Web of Science of Clarivate Analytics. All rights reserved.
You may not copy or re-distribute this material in whole or in part without the prior written consent of Clarivate Analytics.