Clinical features of acute viral hepatitis B in Korea: a multi-center study
DC Field | Value | Language |
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dc.contributor.author | Choi, Hye Jin | - |
dc.contributor.author | Ko, Soon Young | - |
dc.contributor.author | Choe, Won Hyeok | - |
dc.contributor.author | Seo, Yeon Seok | - |
dc.contributor.author | Kim, Ji Hoon | - |
dc.contributor.author | Byun, Kwan Soo | - |
dc.contributor.author | Kim, Young Seok | - |
dc.contributor.author | Kim, Seung Up | - |
dc.contributor.author | Baik, Soon Koo | - |
dc.contributor.author | Cheong, Jae Youn | - |
dc.contributor.author | Kim, Tae Yeob | - |
dc.contributor.author | Oh, Sang Kwon | - |
dc.contributor.author | Kim, Jeong Han | - |
dc.contributor.author | Lee, Chang Hong | - |
dc.contributor.author | Kwon, So Young | - |
dc.date.available | 2020-11-03T04:44:27Z | - |
dc.date.issued | 2011-12 | - |
dc.identifier.issn | 1226-0479 | - |
dc.identifier.uri | https://scholarworks.korea.ac.kr/kumedicine/handle/2020.sw.kumedicine/13974 | - |
dc.description.abstract | Background/Aims The incidence of Hepatitis B has significantly declined since the introduction of an HBV vaccination program. The aim of this study was to investigate recent clinical features of acute viral hepatitis B (AVH-B) in Korea. Methods A total of 2241 patients with acute viral hepatitis were enrolled and their data were collected from nine medical-centers between January 2006 and December 2009. Results One hundred nineteen (5.3%) of the 2241 were diagnosed as AVH-B. Among 78 patients with AVH-B whose data were analyzed, 50 were male, and the mean age was 38.6 years. In an initial test, mean AST, ALT and total-bilirubin levels were 1296.2 IU/L, 2109.6 IU/L and 9.3 mg/dl, respectively. Positivity frequencies for HBeAg and anti-HBe were 55.1% and 67.9%, respectively, and the mean HBV DNA level was 5.2 log10 copies/ml. The mean length of hospitalization was 11.6 days. During follow-up, AST, ALT and total bilirubin levels were normalized or near-normalized in all patients without serious complications. Sixty-three of 66 (95.4%) patients showed HBsAg loss and 37 (56.1%) patients showed HBsAg seroconversion. Only 3 patients (4.5%) showed persistent hepatitis B viremia. There was no case of death or liver transplantation. Nine patients (11.3%) had received anti-viral agents and their clinical outcomes were not significantly different from those of patients treated without antiviral agents. Conclusions The prevalence of AVH-B among acute hepatitis patients is relatively low in Korea. AVH-B infection can be cured without complications in almost all patients, regardless of antiviral treatment. | - |
dc.format.extent | 6 | - |
dc.language | 영어 | - |
dc.language.iso | ENG | - |
dc.publisher | 대한간학회 | - |
dc.title | Clinical features of acute viral hepatitis B in Korea: a multi-center study | - |
dc.type | Article | - |
dc.publisher.location | 대한민국 | - |
dc.identifier.doi | 10.3350/kjhep.2011.17.4.307 | - |
dc.identifier.scopusid | 2-s2.0-84861315692 | - |
dc.identifier.bibliographicCitation | The Korean Journal of Hepatology, v.17, no.4, pp 307 - 312 | - |
dc.citation.title | The Korean Journal of Hepatology | - |
dc.citation.volume | 17 | - |
dc.citation.number | 4 | - |
dc.citation.startPage | 307 | - |
dc.citation.endPage | 312 | - |
dc.identifier.kciid | ART001611286 | - |
dc.description.isOpenAccess | N | - |
dc.description.journalRegisteredClass | kci | - |
dc.subject.keywordAuthor | Acute hepatitis B | - |
dc.subject.keywordAuthor | Prevalence | - |
dc.subject.keywordAuthor | Prognosis | - |
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