Quantitative measurement of serum hepatitis B surface antigen using an immunoradiometric assay in chronic hepatitis B
DC Field | Value | Language |
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dc.contributor.author | Kwon H.-W. | - |
dc.contributor.author | Lee H.-Y. | - |
dc.contributor.author | Kim S.G. | - |
dc.contributor.author | Kim W. | - |
dc.contributor.author | Jung Y.J. | - |
dc.contributor.author | Kang K.W. | - |
dc.contributor.author | Chung J.-K. | - |
dc.contributor.author | Lee M.C. | - |
dc.contributor.author | Lee D.S. | - |
dc.date.available | 2020-11-03T04:46:21Z | - |
dc.date.issued | 2011 | - |
dc.identifier.issn | 1869-3474 | - |
dc.identifier.issn | 1869-3482 | - |
dc.identifier.uri | https://scholarworks.korea.ac.kr/kumedicine/handle/2020.sw.kumedicine/14089 | - |
dc.description.abstract | Purpose: Measurement of serum hepatitis B virus surface antigen (HBsAg) levels is important for the management of chronic hepatitis B patients in terms of monitoring response to antiviral therapy. This study aimed to evaluate the diagnostic performance of a new diagnostic kit, which quantitatively measures serum HBsAg level using an immunoradiometric assay (IRMA)-based method. Measurements were compared with those obtained using a chemiluminescent microparticle immunoassay (CMIA)-based method. Methods: The blood samples of 96 patients with chronic hepatitis B were used in this study. Copy numbers of serum hepatitis B virus (HBV) DNA were determined in 23 of these samples. The correlation between and the concordance of IRMA and CMIA results were determined using Pearson's correlation coefficients. P values of 0.05 were considered to be statistically significant throughout. Results: Laboratory diagnoses based on IRMA were wholly in agreement with those based on CMIA. Furthermore, serum HBsAg levels by IRMA were found to be highly correlated with those determined by CMIA (correlation coefficient R2 = 0.838, p<0.001). Serum HBsAg level and serum HBV DNA copies were found to be linearly related by both methods (R2 = 0.067, p=0.316 by IRMA, and R2 = 0.101, p=0.215 by CMIA). Conclusion: The diagnostic performance of the investigated IRMA method of determining HBsAg levels was found to be comparable with that of a CMIA-based method in chronic hepatitis B patients. © Korean Society of Nuclear Medicine 2010. | - |
dc.format.extent | 6 | - |
dc.language | 영어 | - |
dc.language.iso | ENG | - |
dc.title | Quantitative measurement of serum hepatitis B surface antigen using an immunoradiometric assay in chronic hepatitis B | - |
dc.type | Article | - |
dc.publisher.location | 독일 | - |
dc.identifier.doi | 10.1007/s13139-010-0061-9 | - |
dc.identifier.scopusid | 2-s2.0-79952072990 | - |
dc.identifier.bibliographicCitation | Nuclear Medicine and Molecular Imaging, v.45, no.1, pp 15 - 20 | - |
dc.citation.title | Nuclear Medicine and Molecular Imaging | - |
dc.citation.volume | 45 | - |
dc.citation.number | 1 | - |
dc.citation.startPage | 15 | - |
dc.citation.endPage | 20 | - |
dc.type.docType | Article | - |
dc.description.isOpenAccess | N | - |
dc.description.journalRegisteredClass | scopus | - |
dc.description.journalRegisteredClass | kci | - |
dc.subject.keywordPlus | hepatitis B surface antigen | - |
dc.subject.keywordPlus | virus DNA | - |
dc.subject.keywordPlus | article | - |
dc.subject.keywordPlus | blood analysis | - |
dc.subject.keywordPlus | blood sampling | - |
dc.subject.keywordPlus | chemoluminescence | - |
dc.subject.keywordPlus | clinical evaluation | - |
dc.subject.keywordPlus | comparative effectiveness | - |
dc.subject.keywordPlus | controlled study | - |
dc.subject.keywordPlus | diagnostic kit | - |
dc.subject.keywordPlus | gene dosage | - |
dc.subject.keywordPlus | hepatitis B | - |
dc.subject.keywordPlus | Hepatitis B virus | - |
dc.subject.keywordPlus | human | - |
dc.subject.keywordPlus | immunoradiometric assay | - |
dc.subject.keywordPlus | intermethod comparison | - |
dc.subject.keywordPlus | laboratory diagnosis | - |
dc.subject.keywordPlus | priority journal | - |
dc.subject.keywordPlus | quantitative analysis | - |
dc.subject.keywordAuthor | Chemiluminescent microparticle immunoassay | - |
dc.subject.keywordAuthor | Chronic hepatitis B | - |
dc.subject.keywordAuthor | Hepatitis B virus surface antigen | - |
dc.subject.keywordAuthor | Immunoradiometric assay | - |
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