Dipeptidyl-peptidase-4 (DPP-4) inhibitor ameliorates 5-flurouracil induced intestinal mucositis
DC Field | Value | Language |
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dc.contributor.author | Lee, Jung Min | - |
dc.contributor.author | Yoo, In Kyung | - |
dc.contributor.author | Lee, Jae Min | - |
dc.contributor.author | Kim, Seung Han | - |
dc.contributor.author | Choi, Hyuk Soon | - |
dc.contributor.author | Kim, Eun Sun | - |
dc.contributor.author | Keum, Bora | - |
dc.contributor.author | Seo, Yeon Seok | - |
dc.contributor.author | Jeen, Yoon Tae | - |
dc.contributor.author | Chun, Hoon Jai | - |
dc.contributor.author | Lee, Hong Sik | - |
dc.contributor.author | Um, Soon Ho | - |
dc.contributor.author | Kim, Chang Duck | - |
dc.date.available | 2020-11-02T06:29:31Z | - |
dc.date.issued | 2019-10 | - |
dc.identifier.issn | 1471-2407 | - |
dc.identifier.issn | 1471-2407 | - |
dc.identifier.uri | https://scholarworks.korea.ac.kr/kumedicine/handle/2020.sw.kumedicine/1506 | - |
dc.description.abstract | Background: Chemotherapy-induced alimentary mucositis (AM) is difficult to prevent and treatment is rarely effective. Recent study have been showed that glucagon-like peptide (GLP)-1 and GLP-2 has protective in chemotherapy-induced AM. While the DPP-4 enzyme degrades this GLP-1, the DPP-4 inhibitor blocks the degradation process and raises the concentration of GLP-1. This study aimed to assess the role of DPP-4 inhibitor, a well-known hypoglycemic agent, on chemotherapy-induced AM. Methods: Twenty-four 6-week-old male C57BL/6 mice were divided into 4 groups: control, 5-fluorouracil (5-FU), DPP-4 inhibitor, and saline (DPP-4i), and DPP-4 inhibitor and 5-FU (DPP-4i + 5-FU). Mucositis was induced by intraperitoneal injection of 5-FU (400 mg/kg). DPP-4 inhibitor (50 mg/kg) was administered orally for four days starting the day before 5-FU administration. Post 72 h of 5-FU injection, mice were sacrificed and body weight change, diarrhea score, villus height, villus/crypt ratio, histologic characteristics including goblet cell count, and mRNA expression of inflammatory cytokines tumor necrosis factor (TNF)-alpha and interleukin (IL)-6, were assessed. Results: Daily body weight change was not statistically significant between the 5-FU and the DPP-4i + 5-FU group (P = 0.571). Diarrhea score was significantly different between these two groups (P = 0.033). In the 5-FU group, the villus height was not maintained well, the epithelial lining was irregular, and inflammatory cell infiltration was observed. Goblet cell count in the DPP-4i + 5-FU group was significantly higher than in the 5-FU group (P = 0.007). However, in the DPP-4i + 5-FU group, the villus height, epithelial lining, and crypt structure were better maintained than in the 5-FU group. Compared with the control group, mRNA expression of TNF-alpha was significantly up-regulated in the 5-FU group. Moreover, mRNA expression of TNF-alpha in the DPP-4i + 5-FU group was down-regulated compared to the 5-FU group. However, IL-6 in the 5-FU group was significantly down-regulated compared to the control, there was no significant difference in expression of IL-6 between the 5-FU and DPP4i + 5-FU group. Conclusion: DPP-4 inhibitor can improve 5-FU induced AM and, therefore, has potential as an alternative treatment for chemotherapy-induced AM. | - |
dc.language | 영어 | - |
dc.language.iso | ENG | - |
dc.publisher | BMC | - |
dc.title | Dipeptidyl-peptidase-4 (DPP-4) inhibitor ameliorates 5-flurouracil induced intestinal mucositis | - |
dc.type | Article | - |
dc.publisher.location | 영국 | - |
dc.identifier.doi | 10.1186/s12885-019-6231-y | - |
dc.identifier.scopusid | 2-s2.0-85074374318 | - |
dc.identifier.wosid | 000499688600004 | - |
dc.identifier.bibliographicCitation | BMC CANCER, v.19, no.1 | - |
dc.citation.title | BMC CANCER | - |
dc.citation.volume | 19 | - |
dc.citation.number | 1 | - |
dc.type.docType | Article | - |
dc.description.isOpenAccess | N | - |
dc.description.journalRegisteredClass | scie | - |
dc.description.journalRegisteredClass | scopus | - |
dc.relation.journalResearchArea | Oncology | - |
dc.relation.journalWebOfScienceCategory | Oncology | - |
dc.subject.keywordPlus | GLUCAGON-LIKE PEPTIDE-1 | - |
dc.subject.keywordPlus | INDUCED ORAL MUCOSITIS | - |
dc.subject.keywordPlus | NECROSIS-FACTOR-ALPHA | - |
dc.subject.keywordPlus | MANAGEMENT | - |
dc.subject.keywordPlus | APOPTOSIS | - |
dc.subject.keywordAuthor | Chemotherapy | - |
dc.subject.keywordAuthor | Alimentary mucositis | - |
dc.subject.keywordAuthor | Anti-inflammatory | - |
dc.subject.keywordAuthor | Fluorouracil | - |
dc.subject.keywordAuthor | Dipeptidyl-peptidase-4 inhibitor | - |
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