Serum cystatin C level is a good prognostic marker in patients with cirrhotic ascites and normal serum creatinine levels
DC Field | Value | Language |
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dc.contributor.author | Seo, Yeon Seok | - |
dc.contributor.author | Jung, Eun Suk | - |
dc.contributor.author | An, Hyonggin | - |
dc.contributor.author | Kim, Jeong Han | - |
dc.contributor.author | Jung, Young Kul | - |
dc.contributor.author | Kim, Ji Hoon | - |
dc.contributor.author | Yim, Hyung Joon | - |
dc.contributor.author | Yeon, Jong Eun | - |
dc.contributor.author | Byun, Kwan Soo | - |
dc.contributor.author | Kim, Chang Duck | - |
dc.contributor.author | Ryu, Ho Sang | - |
dc.contributor.author | Um, Soon Ho | - |
dc.date.available | 2020-11-03T07:46:54Z | - |
dc.date.issued | 2009-11 | - |
dc.identifier.issn | 1478-3223 | - |
dc.identifier.issn | 1478-3231 | - |
dc.identifier.uri | https://scholarworks.korea.ac.kr/kumedicine/handle/2020.sw.kumedicine/15676 | - |
dc.description.abstract | Background/Aims: Serum creatinine (Cr) is not a reliable marker for early detection of renal dysfunction in patients with cirrhotic ascites. Several reports have suggested that cystatin C (CysC) is more sensitive than Cr for detecting reduced renal function in these patients. This study evaluated the clinical significance of CysC in patients with cirrhotic ascites and a normal serum Cr level. Methods: We enrolled patients with ascites and a normal serum Cr level (<1.2 mg/dl). Liver function tests, international normalized ratio (INR) and serum Cr and CysC levels were measured on the same day for all patients. CysC levels were measured using the automated latex-enhanced immunonephelometric method. The endpoint of follow-up was the development of hepatorenal syndrome (HRS) or mortality. Results: Seventy-eight patients with cirrhotic ascites were enrolled in the study (58 men and 30 women; age, 53±11 years). The underlying liver diseases in these patients were chronic hepatitis B (37%), chronic hepatitis C (4%), alcoholic liver disease (53%) and others (6%). Forty-six (59%) and 32 (41%) patients were in Child–Pugh classes B and C respectively. HRS developed in 14 patients during the follow-up period (349±241 days), with cumulative incidences of 10.2% and 20.4% at 6 and 12 months respectively. The CysC level was the only independent predictive factor for HRS. Twenty-three patients died during the follow-up period. CysC level and INR were independent factors for predicting mortality. Conclusion: Serum CysC level is a good marker for predicting HRS and survival in patients with cirrhotic ascites and a normal Cr level. | - |
dc.format.extent | 7 | - |
dc.language | 영어 | - |
dc.language.iso | ENG | - |
dc.publisher | Blackwell Publishing Inc. | - |
dc.title | Serum cystatin C level is a good prognostic marker in patients with cirrhotic ascites and normal serum creatinine levels | - |
dc.type | Article | - |
dc.publisher.location | 미국 | - |
dc.identifier.doi | 10.1111/j.1478-3231.2009.02105.x | - |
dc.identifier.scopusid | 2-s2.0-73449108407 | - |
dc.identifier.wosid | 000270429000012 | - |
dc.identifier.bibliographicCitation | Liver International, v.29, no.10, pp 1521 - 1527 | - |
dc.citation.title | Liver International | - |
dc.citation.volume | 29 | - |
dc.citation.number | 10 | - |
dc.citation.startPage | 1521 | - |
dc.citation.endPage | 1527 | - |
dc.type.docType | Article | - |
dc.description.isOpenAccess | N | - |
dc.description.journalRegisteredClass | scopus | - |
dc.relation.journalResearchArea | Gastroenterology & Hepatology | - |
dc.relation.journalWebOfScienceCategory | Gastroenterology & Hepatology | - |
dc.subject.keywordPlus | GLOMERULAR-FILTRATION-RATE | - |
dc.subject.keywordPlus | STAGE LIVER-DISEASE | - |
dc.subject.keywordPlus | RENAL-FUNCTION | - |
dc.subject.keywordPlus | HEPATORENAL-SYNDROME | - |
dc.subject.keywordPlus | SURVIVAL | - |
dc.subject.keywordPlus | MODEL | - |
dc.subject.keywordPlus | TRANSPLANTATION | - |
dc.subject.keywordPlus | PREDICTION | - |
dc.subject.keywordPlus | CLEARANCE | - |
dc.subject.keywordPlus | TERLIPRESSIN | - |
dc.subject.keywordAuthor | ascites | - |
dc.subject.keywordAuthor | creatinine | - |
dc.subject.keywordAuthor | cystatin C | - |
dc.subject.keywordAuthor | liver cirrhosis | - |
dc.subject.keywordAuthor | renal dysfunction | - |
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