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Cited 36 time in webofscience Cited 38 time in scopus
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Serum cystatin C level is a good prognostic marker in patients with cirrhotic ascites and normal serum creatinine levels

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dc.contributor.authorSeo, Yeon Seok-
dc.contributor.authorJung, Eun Suk-
dc.contributor.authorAn, Hyonggin-
dc.contributor.authorKim, Jeong Han-
dc.contributor.authorJung, Young Kul-
dc.contributor.authorKim, Ji Hoon-
dc.contributor.authorYim, Hyung Joon-
dc.contributor.authorYeon, Jong Eun-
dc.contributor.authorByun, Kwan Soo-
dc.contributor.authorKim, Chang Duck-
dc.contributor.authorRyu, Ho Sang-
dc.contributor.authorUm, Soon Ho-
dc.date.available2020-11-03T07:46:54Z-
dc.date.issued2009-11-
dc.identifier.issn1478-3223-
dc.identifier.issn1478-3231-
dc.identifier.urihttps://scholarworks.korea.ac.kr/kumedicine/handle/2020.sw.kumedicine/15676-
dc.description.abstractBackground/Aims: Serum creatinine (Cr) is not a reliable marker for early detection of renal dysfunction in patients with cirrhotic ascites. Several reports have suggested that cystatin C (CysC) is more sensitive than Cr for detecting reduced renal function in these patients. This study evaluated the clinical significance of CysC in patients with cirrhotic ascites and a normal serum Cr level. Methods: We enrolled patients with ascites and a normal serum Cr level (<1.2 mg/dl). Liver function tests, international normalized ratio (INR) and serum Cr and CysC levels were measured on the same day for all patients. CysC levels were measured using the automated latex-enhanced immunonephelometric method. The endpoint of follow-up was the development of hepatorenal syndrome (HRS) or mortality. Results: Seventy-eight patients with cirrhotic ascites were enrolled in the study (58 men and 30 women; age, 53±11 years). The underlying liver diseases in these patients were chronic hepatitis B (37%), chronic hepatitis C (4%), alcoholic liver disease (53%) and others (6%). Forty-six (59%) and 32 (41%) patients were in Child–Pugh classes B and C respectively. HRS developed in 14 patients during the follow-up period (349±241 days), with cumulative incidences of 10.2% and 20.4% at 6 and 12 months respectively. The CysC level was the only independent predictive factor for HRS. Twenty-three patients died during the follow-up period. CysC level and INR were independent factors for predicting mortality. Conclusion: Serum CysC level is a good marker for predicting HRS and survival in patients with cirrhotic ascites and a normal Cr level.-
dc.format.extent7-
dc.language영어-
dc.language.isoENG-
dc.publisherBlackwell Publishing Inc.-
dc.titleSerum cystatin C level is a good prognostic marker in patients with cirrhotic ascites and normal serum creatinine levels-
dc.typeArticle-
dc.publisher.location미국-
dc.identifier.doi10.1111/j.1478-3231.2009.02105.x-
dc.identifier.scopusid2-s2.0-73449108407-
dc.identifier.wosid000270429000012-
dc.identifier.bibliographicCitationLiver International, v.29, no.10, pp 1521 - 1527-
dc.citation.titleLiver International-
dc.citation.volume29-
dc.citation.number10-
dc.citation.startPage1521-
dc.citation.endPage1527-
dc.type.docTypeArticle-
dc.description.isOpenAccessN-
dc.description.journalRegisteredClassscopus-
dc.relation.journalResearchAreaGastroenterology & Hepatology-
dc.relation.journalWebOfScienceCategoryGastroenterology & Hepatology-
dc.subject.keywordPlusGLOMERULAR-FILTRATION-RATE-
dc.subject.keywordPlusSTAGE LIVER-DISEASE-
dc.subject.keywordPlusRENAL-FUNCTION-
dc.subject.keywordPlusHEPATORENAL-SYNDROME-
dc.subject.keywordPlusSURVIVAL-
dc.subject.keywordPlusMODEL-
dc.subject.keywordPlusTRANSPLANTATION-
dc.subject.keywordPlusPREDICTION-
dc.subject.keywordPlusCLEARANCE-
dc.subject.keywordPlusTERLIPRESSIN-
dc.subject.keywordAuthorascites-
dc.subject.keywordAuthorcreatinine-
dc.subject.keywordAuthorcystatin C-
dc.subject.keywordAuthorliver cirrhosis-
dc.subject.keywordAuthorrenal dysfunction-
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2. Clinical Science > Department of Internal Medicine > 1. Journal Articles
1. Basic Science > Department of Biostatistics > 1. Journal Articles
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