Detailed Information

Cited 8 time in webofscience Cited 9 time in scopus
Metadata Downloads

Association between Antipsychotics-Induced Restless Legs Syndrome and Tyrosine Hydroxylase Gene Polymorphism

Full metadata record
DC FieldValueLanguage
dc.contributor.authorCho, Chul-Hyun-
dc.contributor.authorKang, Seung-Gul-
dc.contributor.authorChoi, Jung-Eun-
dc.contributor.authorPark, Young-Min-
dc.contributor.authorLee, Heon-Jeong-
dc.contributor.authorKim, Leen-
dc.date.available2020-11-03T07:48:44Z-
dc.date.created2020-10-17-
dc.date.issued2009-09-
dc.identifier.issn1738-3684-
dc.identifier.urihttps://scholarworks.korea.ac.kr/kumedicine/handle/2020.sw.kumedicine/15798-
dc.description.abstractObjective Restless legs syndrome (RLS) has been reported to be more prevalent in schizophrenic patients who take, antipsychotics. The cause of RLS is unknown but associated with dopaminergic deficiency. Tyrosine hydroxylase (TH) is the enzyme responsible for catalyzing the conversion of tyrosine to DOPA. The purpose of this study is to determine whether the TH gene Val81Met polymorphism is associated with antipsychotic-induced RLS. Methods One hundred ninety Korean schizophrenic patients were evaluated by the diagnostic criteria of the International RLS Study Group (IRLSSG). The genotyping was performed by PCR-based methods. Results Of the hundred ninety schizophrenic patients, 44 (23.2%) were found to have RLS. Although there were no significant associations between TH genotypes or allele frequencies and RLS, when separate analyses were performed by sex (male or female), we significant differences in the frequencies of the genotype (chi(2)=6.15, p=0.046) and (chi(2)=4.67, p=0.031) of the TH gene Val81 polymorphism between those with and without RLS in the female the patients. Conclusion These findings suggest that the TH gene Val81Met SNP might be associated with antipsychotic-induced RLS in female schizophrenic patients.-
dc.language영어-
dc.publisherKOREAN NEUROPSYCHIATRIC ASSOC-
dc.subjectPARKINSONS-DISEASE-
dc.subjectDOPAMINE SYNTHESIS-
dc.subjectADULT-POPULATION-
dc.subjectRATING-SCALE-
dc.subjectRISK-FACTORS-
dc.subjectSCHIZOPHRENIA-
dc.subjectPREVALENCE-
dc.subjectEPIDEMIOLOGY-
dc.subjectSEVERITY-
dc.subjectESTROGEN-
dc.titleAssociation between Antipsychotics-Induced Restless Legs Syndrome and Tyrosine Hydroxylase Gene Polymorphism-
dc.typeArticle-
dc.contributor.affiliatedAuthorLee, Heon-Jeong-
dc.contributor.affiliatedAuthorKim, Leen-
dc.identifier.doi10.4306/pi.2009.6.3.211-
dc.identifier.scopusid2-s2.0-70350073884-
dc.identifier.wosid000270132200013-
dc.identifier.bibliographicCitationPSYCHIATRY INVESTIGATION, v.6, no.3, pp.211 - 215-
dc.relation.isPartOfPSYCHIATRY INVESTIGATION-
dc.citation.titlePSYCHIATRY INVESTIGATION-
dc.citation.volume6-
dc.citation.number3-
dc.citation.startPage211-
dc.citation.endPage215-
dc.type.rimsART-
dc.type.docTypeArticle-
dc.identifier.kciidART001384441-
dc.description.journalClass1-
dc.description.journalRegisteredClassscie-
dc.description.journalRegisteredClassscopus-
dc.description.journalRegisteredClasskci-
dc.description.journalRegisteredClassother-
dc.relation.journalResearchAreaPsychiatry-
dc.relation.journalWebOfScienceCategoryPsychiatry-
dc.subject.keywordPlusPARKINSONS-DISEASE-
dc.subject.keywordPlusDOPAMINE SYNTHESIS-
dc.subject.keywordPlusADULT-POPULATION-
dc.subject.keywordPlusRATING-SCALE-
dc.subject.keywordPlusRISK-FACTORS-
dc.subject.keywordPlusSCHIZOPHRENIA-
dc.subject.keywordPlusPREVALENCE-
dc.subject.keywordPlusEPIDEMIOLOGY-
dc.subject.keywordPlusSEVERITY-
dc.subject.keywordPlusESTROGEN-
dc.subject.keywordAuthorRestless legs syndrome-
dc.subject.keywordAuthorAntipsychotic-
dc.subject.keywordAuthorSchizophrenia-
dc.subject.keywordAuthorTyrosine hydroxylase-
dc.subject.keywordAuthorPolymorphism-
Files in This Item
There are no files associated with this item.
Appears in
Collections
2. Clinical Science > Department of Psychiatry > 1. Journal Articles

qrcode

Items in ScholarWorks are protected by copyright, with all rights reserved, unless otherwise indicated.

Related Researcher

Researcher Kim, Leen photo

Kim, Leen
Anam Hospital (Department of Psychiatry, Anam Hospital)
Read more

Altmetrics

Total Views & Downloads

BROWSE