G-protein beta 3 Subunit Gene 82SC/T Polymorphism Is Not Associated with Olanzapine-Induced Weight Gain in Korean Schizophrenic Patients
DC Field | Value | Language |
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dc.contributor.author | Park, Young-Min | - |
dc.contributor.author | Chung, Young-Cho | - |
dc.contributor.author | Lee, Seung-Hwan | - |
dc.contributor.author | Lee, Kang-Joon | - |
dc.contributor.author | Kim, Hyun | - |
dc.contributor.author | Choi, Jung-Eun | - |
dc.contributor.author | Kang, Seung-Gul | - |
dc.contributor.author | Lee, Min-Soo | - |
dc.contributor.author | Kim, Leen | - |
dc.contributor.author | Lee, Heon-Jeong | - |
dc.date.available | 2020-11-03T08:47:01Z | - |
dc.date.issued | 2009-03 | - |
dc.identifier.issn | 1738-3684 | - |
dc.identifier.issn | 1976-3026 | - |
dc.identifier.uri | https://scholarworks.korea.ac.kr/kumedicine/handle/2020.sw.kumedicine/16192 | - |
dc.description.abstract | Objective Weight gain is a possible adverse effect of the use of antipsychotics, and is an important factor for long-term health and treatment compliance. Olanzapine is an atypical antipsychotic known to cause considerable weight gain. A relationship between weight gain and the G protein beta 3 subunit gene (GNB3) 825C/T polymorphism has been reported. We therefore examined this possible association in a Korean schizophrenic patient group receiving olanzapine treatment. Methods Weight and height measurements were obtained prior to starting olanzapine and measured again after long-term treatment. Genotyping for the 825C/T polymorphism was performed using a PCR-based method. Results We found that long-term treatment with olanzapine resulted in mean gains in weight and body mass index (BMI) of 5.2 kg and 1.93 kg/m(2), respectively. There was a no significant difference in the mean body weight it change from baseline to the endpoint after olanzapine treatment between the genotype groups (p=0.796). There were also no significant differences in genotype or allele frequencies between the severe weight-gain (more than 10%) and minimal weight-gain (less than 10%) groups (chi(2)=0.037, p=0.98; chi(2)=0.020, p=0.89). Conclusion The Finding from this study thus does not support a relationship between the GNB3 825C/T polymorphism and weight gain in Korean schizophrenic patients receiving olanzapine treatment. | - |
dc.format.extent | 5 | - |
dc.language | 영어 | - |
dc.language.iso | ENG | - |
dc.publisher | KOREAN NEUROPSYCHIATRIC ASSOC | - |
dc.title | G-protein beta 3 Subunit Gene 82SC/T Polymorphism Is Not Associated with Olanzapine-Induced Weight Gain in Korean Schizophrenic Patients | - |
dc.type | Article | - |
dc.publisher.location | 대한민국 | - |
dc.identifier.doi | 10.4306/pi.2009.6.1.39 | - |
dc.identifier.scopusid | 2-s2.0-64249151960 | - |
dc.identifier.wosid | 000265363600007 | - |
dc.identifier.bibliographicCitation | PSYCHIATRY INVESTIGATION, v.6, no.1, pp 39 - 43 | - |
dc.citation.title | PSYCHIATRY INVESTIGATION | - |
dc.citation.volume | 6 | - |
dc.citation.number | 1 | - |
dc.citation.startPage | 39 | - |
dc.citation.endPage | 43 | - |
dc.type.docType | Article | - |
dc.identifier.kciid | ART001331533 | - |
dc.description.isOpenAccess | N | - |
dc.description.journalRegisteredClass | scie | - |
dc.description.journalRegisteredClass | scopus | - |
dc.description.journalRegisteredClass | kciCandi | - |
dc.relation.journalResearchArea | Psychiatry | - |
dc.relation.journalWebOfScienceCategory | Psychiatry | - |
dc.subject.keywordPlus | STIMULATORY ALPHA-SUBUNIT | - |
dc.subject.keywordPlus | BODY-MASS INDEX | - |
dc.subject.keywordPlus | QUALITY-OF-LIFE | - |
dc.subject.keywordPlus | C825T POLYMORPHISM | - |
dc.subject.keywordPlus | 825T ALLELE | - |
dc.subject.keywordPlus | ANTIPSYCHOTIC MEDICATIONS | - |
dc.subject.keywordPlus | CLOZAPINE TREATMENT | - |
dc.subject.keywordPlus | C/T POLYMORPHISM | - |
dc.subject.keywordPlus | SPLICE VARIANT | - |
dc.subject.keywordPlus | HYPERTENSION | - |
dc.subject.keywordAuthor | Olanzapine | - |
dc.subject.keywordAuthor | Weight | - |
dc.subject.keywordAuthor | Polymorphism | - |
dc.subject.keywordAuthor | Schizophrenia | - |
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