Effects of rhBMP-2 Coating Tricalcium Phosphate on Socket Preservation in Dog Extraction Socket

Abstract

Recently, research about bone morphogenetic protein(BMP) has become a field in which advances are consistently and constantly being made due to possibility in substitution for bone graft. The purpose of present study was to evaluate the efficacy of BMP-2 for bone regeneration during socket healing after teeth extraction through the volumetric analysis of extraction sockets using cone beam computed tomography(CBCT). In six dogs, the both side 3rd and 4th mandibular pre-molars were hemi-sected and the distal roots were removed. The distal extraction socket of left side of the pre-molars were filled with BMP-2 coating TCP. The socket of the contra-lateral pre-molars were left without bone graft. The three dogs were sacrificed after 4 weeks of healing, the other three dogs were sacrificed after 12 weeks. Then, the tooth socket was scanned with CBCT and data were uploaded in consecutive 1 mm-thick two-dimensional slices. The total volume of the delineated socket was computed. The results were statistically analyzed using ANOVA and Multiple comparison test. There were no differences in the width of socket between 2 groups after four and twelve weeks healing. However, BMP-2 coated TCP have efficacy to preserve vertical dimension of bone as a bone graft material in socket after 4 weeks of healing(p<0.05). Within the limit of the results of this study, BMP-2 coating TCP can preserve the socket height in early stage in dog mandible.