Stretching Causes Extensive Changes of Gastric Submucosa: Is It Acceptable to Define 500 mu m as the Safe Margin?
DC Field | Value | Language |
---|---|---|
dc.contributor.author | Park, Sanghoon | - |
dc.contributor.author | Chun, Hoon Jai | - |
dc.contributor.author | Kwon, Yong Dae | - |
dc.contributor.author | Keum, Bora | - |
dc.contributor.author | Seo, Yeon Seok | - |
dc.contributor.author | Kim, Yong Sik | - |
dc.contributor.author | Jeen, Yoon-Tae | - |
dc.contributor.author | Um, Soon Ho | - |
dc.contributor.author | Kim, Chang Duck | - |
dc.contributor.author | Ryu, Ho Sang | - |
dc.contributor.author | Lee, Ji Hye | - |
dc.contributor.author | Chae, Yang-Seok | - |
dc.date.available | 2020-11-03T09:47:01Z | - |
dc.date.issued | 2008-12 | - |
dc.identifier.issn | 1976-2283 | - |
dc.identifier.issn | 2005-1212 | - |
dc.identifier.uri | https://scholarworks.korea.ac.kr/kumedicine/handle/2020.sw.kumedicine/16677 | - |
dc.description.abstract | Background/Aims: Endoscopic mucosal resection can cure early gastric cancer. The risk of lymphatic metastasis is related to the depth of submucosal invasion by the mucosal malignancy, with a resection depth of 500 mu m generally accepted as a safe cut-off. However, excessive thinning induced by stretching of the resected tissue sometimes preventing a precise diagnosis. We studied the effects of stretching on different layers and sites of gastric tissue. Methods: Porcine stomachs were cut into 2.0x2.0 cm pieces, and pieces from body were stretched to 2.5, 3.0, and 3.5 cm. Pieces from the cardia, body, and antrum were also stretched to 3.0 cm. The thickness of each layer was measured and analyzed statistically. Results: Whole gastric wall and submucosal layers showed gradual thinning, with stretching to 3.5 cm tearing the tissues and resulting in imperfect extension. The submucosa was thinner in body tissue than in cardia and antrum tissues. Stretching to 3.0 cm induced a consistent decrease in submucosal thickness (30-70%). The change in thickness varied widely between individual samples. Conclusions: A resection margin of 500 mu m might be insufficient for the complete removal of malignancy. Moreover, the thickness of the submucosal layer differs with the gastric site and between individuals. Future studies are needed to confirm the findings in human tissue. (Gut and Liver 2008;2:199-204) | - |
dc.format.extent | 6 | - |
dc.language | 영어 | - |
dc.language.iso | ENG | - |
dc.publisher | EDITORIAL OFFICE GUT & LIVER | - |
dc.title | Stretching Causes Extensive Changes of Gastric Submucosa: Is It Acceptable to Define 500 mu m as the Safe Margin? | - |
dc.type | Article | - |
dc.publisher.location | 대한민국 | - |
dc.identifier.doi | 10.5009/gnl.2008.2.3.199 | - |
dc.identifier.wosid | 000264439100008 | - |
dc.identifier.bibliographicCitation | GUT AND LIVER, v.2, no.3, pp 199 - 204 | - |
dc.citation.title | GUT AND LIVER | - |
dc.citation.volume | 2 | - |
dc.citation.number | 3 | - |
dc.citation.startPage | 199 | - |
dc.citation.endPage | 204 | - |
dc.type.docType | Article | - |
dc.identifier.kciid | ART001570084 | - |
dc.description.isOpenAccess | N | - |
dc.description.journalRegisteredClass | scie | - |
dc.relation.journalResearchArea | Gastroenterology & Hepatology | - |
dc.relation.journalWebOfScienceCategory | Gastroenterology & Hepatology | - |
dc.subject.keywordPlus | ENDOSCOPIC MUCOSAL RESECTION | - |
dc.subject.keywordPlus | MECHANICAL-PROPERTIES | - |
dc.subject.keywordPlus | INJECTION SOLUTIONS | - |
dc.subject.keywordPlus | CANCER | - |
dc.subject.keywordPlus | DIAGNOSIS | - |
dc.subject.keywordPlus | TRACT | - |
dc.subject.keywordAuthor | Stomach neoplasms | - |
dc.subject.keywordAuthor | Gastric mucosa | - |
dc.subject.keywordAuthor | Gastroscopy | - |
dc.subject.keywordAuthor | Submucosa | - |
dc.subject.keywordAuthor | Stretching | - |
Items in ScholarWorks are protected by copyright, with all rights reserved, unless otherwise indicated.
73, Goryeodae-ro, Seongbuk-gu, Seoul, Republic of Korea (02841)82-2-2286-1265
COPYRIGHT 2020 KOREA UNIVERSITY MEDICAL LIBRARY ALL RIGHTS RESERVED.
Certain data included herein are derived from the © Web of Science of Clarivate Analytics. All rights reserved.
You may not copy or re-distribute this material in whole or in part without the prior written consent of Clarivate Analytics.