Possible association between the-2548A/G polymorphism of the leptin gene and olanzapine-induced weight gain
DC Field | Value | Language |
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dc.contributor.author | Kang, Seung-Gul | - |
dc.contributor.author | Lee, Heon-Jeong | - |
dc.contributor.author | Park, Young-Min | - |
dc.contributor.author | Choi, Jung-Eun | - |
dc.contributor.author | Han, Changsu | - |
dc.contributor.author | Kim, Yong-Ku | - |
dc.contributor.author | Kim, Seung-Hyun | - |
dc.contributor.author | Lee, Min-Soo | - |
dc.contributor.author | Joe, Sook-Haeng | - |
dc.contributor.author | Jung, In-Kwa | - |
dc.contributor.author | Kim, Leen | - |
dc.date.available | 2020-11-03T10:48:33Z | - |
dc.date.issued | 2008-01-01 | - |
dc.identifier.issn | 0278-5846 | - |
dc.identifier.issn | 1878-4216 | - |
dc.identifier.uri | https://scholarworks.korea.ac.kr/kumedicine/handle/2020.sw.kumedicine/17201 | - |
dc.description.abstract | Antipsychotic-induced weight gain has important effects on treatment compliance and long-term health. Several reports have indicated that a -2548A/G single-nucleotide polymorphism (SNP) of the leptin gene is associated with antipsychotic-induced weight gain. We hypothesized that there is a similar relationship between the -2548A/G SNP and olanzapine-induced weight gain. A total of 74 Korean schizophrenic patients were examined. Their weight was measured before starting olanzapine and after long-term treatment lasting for at least 3 months. The weight gain was significantly higher for patients with the AG genotype than for those with the AA genotype (p=0.029). Analysis of covariance also showed the difference of weight gain was still significant when adjusted for sex and treatment duration (p=0.046). This finding supports the presence of a relationship between the -2548A/G SNP of the leptin gene and weight gain in Korean schizophrenic patients receiving olanzapine treatment. (c) 2007 Elsevier Inc. All rights reserved. | - |
dc.format.extent | 4 | - |
dc.language | 영어 | - |
dc.language.iso | ENG | - |
dc.publisher | PERGAMON-ELSEVIER SCIENCE LTD | - |
dc.title | Possible association between the-2548A/G polymorphism of the leptin gene and olanzapine-induced weight gain | - |
dc.type | Article | - |
dc.publisher.location | 영국 | - |
dc.identifier.doi | 10.1016/j.pnpbp.2007.08.002 | - |
dc.identifier.scopusid | 2-s2.0-38349056887 | - |
dc.identifier.wosid | 000253565500024 | - |
dc.identifier.bibliographicCitation | PROGRESS IN NEURO-PSYCHOPHARMACOLOGY & BIOLOGICAL PSYCHIATRY, v.32, no.1, pp 160 - 163 | - |
dc.citation.title | PROGRESS IN NEURO-PSYCHOPHARMACOLOGY & BIOLOGICAL PSYCHIATRY | - |
dc.citation.volume | 32 | - |
dc.citation.number | 1 | - |
dc.citation.startPage | 160 | - |
dc.citation.endPage | 163 | - |
dc.type.docType | Review | - |
dc.description.isOpenAccess | N | - |
dc.description.journalRegisteredClass | scie | - |
dc.description.journalRegisteredClass | scopus | - |
dc.relation.journalResearchArea | Neurosciences & Neurology | - |
dc.relation.journalResearchArea | Pharmacology & Pharmacy | - |
dc.relation.journalResearchArea | Psychiatry | - |
dc.relation.journalWebOfScienceCategory | Clinical Neurology | - |
dc.relation.journalWebOfScienceCategory | Neurosciences | - |
dc.relation.journalWebOfScienceCategory | Pharmacology & Pharmacy | - |
dc.relation.journalWebOfScienceCategory | Psychiatry | - |
dc.subject.keywordPlus | BODY-WEIGHT | - |
dc.subject.keywordPlus | OBESE GENE | - |
dc.subject.keywordPlus | OB PROTEIN | - |
dc.subject.keywordPlus | CLOZAPINE | - |
dc.subject.keywordPlus | REGION | - |
dc.subject.keywordPlus | SCHIZOPHRENIA | - |
dc.subject.keywordPlus | ADIPOSITY | - |
dc.subject.keywordPlus | MOUSE | - |
dc.subject.keywordAuthor | leptin gene | - |
dc.subject.keywordAuthor | olanzapine | - |
dc.subject.keywordAuthor | polymorphism | - |
dc.subject.keywordAuthor | schizophrenia | - |
dc.subject.keywordAuthor | weight gain | - |
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