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Changes in liver stiffness during the course of acute hepatitis A.

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dc.contributor.authorSeo Y.S.-
dc.contributor.authorUm S.H.-
dc.contributor.authorSuh S.J.-
dc.contributor.authorJung E.S.-
dc.contributor.authorJang J.S.-
dc.contributor.authorKwon Y.D.-
dc.contributor.authorPark S.H.-
dc.contributor.authorKeum B.-
dc.contributor.authorKim Y.S.-
dc.contributor.authorJeen Y.T.-
dc.contributor.authorChun H.J.-
dc.contributor.authorKim C.D.-
dc.contributor.authorRyu H.S.-
dc.date.available2020-11-03T11:43:51Z-
dc.date.issued2008-12-
dc.identifier.issn1738-222X-
dc.identifier.urihttps://scholarworks.korea.ac.kr/kumedicine/handle/2020.sw.kumedicine/17417-
dc.description.abstractBACKGROUNDS/AIMS: In some patients with chronic hepatitis, liver stiffness (LS) findings do not reflect fibrosis stage. This study was performed to evaluate whether acute liver inflammation could influence LS findings. METHODS: Patients with acute hepatitis A admitted to our hospital were included. Hepatitis was classified on admission using serum ALT and bilirubin levels as inflammation phase, jaundice phase, or recovery phase. Patients who admitted during the recovery phase (whose ALT and bilirubin levels fell continuously during hospitalization) and therefore, their peak-ALT and peak bilirubin levels could not be determined were exduded. Enrolled patients underwent FibroScan during hospitalization and after discharge. RESULTS: Seventy-six patients with acute hepatitis A were enrolled (median age, 29 years; 46 men and 30 women). Among them, 33 (43.4%) and 43 (56.6%) patients were admitted during the inflammation phase and jaundice phase, respectively. For patients admitted during the inflammation phase, mean (+/-SD) time from symptom-onset day to maximum ALT level was 7 (+/-3) days. For all patients, mean time from symptom-onset to maximum bilirubin level was 11 (+/-4) days. Mean LS during admission was 8.9 (+/-Pa (median, 8.4 kPa). LS was significantly correlated with serum bilirubin level, which was the only factor found to be significantly associated with the increased LS (>7.08 kPa). In all patients, LS increased gradually from the symptom-onset and peaked at 8-9 days later. CONCLUSIONS: Severe hepatic inflammation can affect the LS findings and thus, care is required when assessing fibrosis stage using LS measurement in patients with severe inflammation.-
dc.format.extent9-
dc.language영어-
dc.language.isoENG-
dc.titleChanges in liver stiffness during the course of acute hepatitis A.-
dc.typeArticle-
dc.publisher.location대한민국-
dc.identifier.doi10.3350/kjhep.2008.14.4.465-
dc.identifier.scopusid2-s2.0-63249135635-
dc.identifier.bibliographicCitationThe Korean journal of hepatology, v.14, no.4, pp 465 - 473-
dc.citation.titleThe Korean journal of hepatology-
dc.citation.volume14-
dc.citation.number4-
dc.citation.startPage465-
dc.citation.endPage473-
dc.type.docTypeArticle-
dc.identifier.kciidART001301091-
dc.description.isOpenAccessN-
dc.description.journalRegisteredClassscopus-
dc.description.journalRegisteredClasskci-
dc.subject.keywordPlusalanine aminotransferase-
dc.subject.keywordPlusbilirubin-
dc.subject.keywordPlusacute disease-
dc.subject.keywordPlusadult-
dc.subject.keywordPlusarticle-
dc.subject.keywordPlusblood-
dc.subject.keywordPlusechography-
dc.subject.keywordPluselastography-
dc.subject.keywordPlusfemale-
dc.subject.keywordPlushepatitis A-
dc.subject.keywordPlushuman-
dc.subject.keywordPlusliver-
dc.subject.keywordPlusmale-
dc.subject.keywordPluspathology-
dc.subject.keywordPlusretrospective study-
dc.subject.keywordPlusAcute Disease-
dc.subject.keywordPlusAdult-
dc.subject.keywordPlusAlanine Transaminase-
dc.subject.keywordPlusBilirubin-
dc.subject.keywordPlusElasticity Imaging Techniques-
dc.subject.keywordPlusFemale-
dc.subject.keywordPlusHepatitis A-
dc.subject.keywordPlusHumans-
dc.subject.keywordPlusLiver-
dc.subject.keywordPlusMale-
dc.subject.keywordPlusRetrospective Studies-
dc.subject.keywordAuthorLiver stiffness-
dc.subject.keywordAuthorFibrosis-
dc.subject.keywordAuthorInflammation-
dc.subject.keywordAuthorAcute hepatitis-
dc.subject.keywordAuthor간섬유화-
dc.subject.keywordAuthor간 강성도-
dc.subject.keywordAuthor괴사염증-
dc.subject.keywordAuthor급성 간염-
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2. Clinical Science > Department of Internal Medicine > 1. Journal Articles
5. Others > Others(Medicine) > 1. Journal Articles
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