Antiviral efficacy of adefovir dipivoxil versus lamivudine in patients with chronic hepatitis B sequentially treated with lamivudine and adefovir due to lamivudine resistance
DC Field | Value | Language |
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dc.contributor.author | Seo, Yeon Seok | - |
dc.contributor.author | Kim, Ji Hoon | - |
dc.contributor.author | Yeon, Jong Eun | - |
dc.contributor.author | Park, Jong-Jae | - |
dc.contributor.author | Kim, Jae Seon | - |
dc.contributor.author | Byun, Kwan Soo | - |
dc.contributor.author | Bak, Young-Tae | - |
dc.contributor.author | Lee, Chang Hong | - |
dc.date.available | 2020-11-03T11:49:35Z | - |
dc.date.issued | 2007-08 | - |
dc.identifier.issn | 1007-9327 | - |
dc.identifier.issn | 2219-2840 | - |
dc.identifier.uri | https://scholarworks.korea.ac.kr/kumedicine/handle/2020.sw.kumedicine/17795 | - |
dc.description.abstract | AIM: To compare the antiviral efficacy of adefovir (ADV) in lamivudine (LMV)-resistant patients with LMV treatment in nucleoside-naïve patients, using serum samples collected sequentially during the course of treatment progressing from LMV to ADV. METHODS: Forty-four patients with chronic hepatitis B (CHB) were included. The patients were initially treated with LMV and then switched to ADV when LMV resistance developed. Antiviral efficacy was assessed by measuring the following: reduction in serum HBV DNA from baseline, HBV DNA negative conversion (defined as HBV DNA being undectable by the hybridization assay), and HBV DNA response (either HBV DNA level ≤ 105 copies/mL or a ≥ 2 log10 reduction from baseline HBV DNA level). RESULTS: After two and six months of treatment, HBV DNA reduction was greater with LMV compared to ADV treatment (P = 0.021). HBV DNA negative conversion rates were 64% and 27% after one month of LMV and ADV treatment respectively (P = 0.001). Similarly, HBV DNA response rates were 74% and 51% after two months of LMV and ADV treatment respectively (P = 0.026). The time taken to HBV DNA negative conversion and to HBV DNA response were both delayed in ADV treatment compared with LMV. CONCLUSION: The antiviral efficacy of ADV in LMV-resistant patients is slower and less potent than that with LMV in nucleoside-naïve patients during the early course of treatment. | - |
dc.format.extent | 8 | - |
dc.language | 영어 | - |
dc.language.iso | ENG | - |
dc.publisher | Baishideng Publishing Group | - |
dc.title | Antiviral efficacy of adefovir dipivoxil versus lamivudine in patients with chronic hepatitis B sequentially treated with lamivudine and adefovir due to lamivudine resistance | - |
dc.type | Article | - |
dc.publisher.location | 미국 | - |
dc.identifier.doi | 10.3748/wjg.v13.i30.4072 | - |
dc.identifier.scopusid | 2-s2.0-34548240700 | - |
dc.identifier.wosid | 000248801300006 | - |
dc.identifier.bibliographicCitation | World Journal of Gastroenterology, v.13, no.30, pp 4072 - 4079 | - |
dc.citation.title | World Journal of Gastroenterology | - |
dc.citation.volume | 13 | - |
dc.citation.number | 30 | - |
dc.citation.startPage | 4072 | - |
dc.citation.endPage | 4079 | - |
dc.type.docType | Article | - |
dc.description.isOpenAccess | N | - |
dc.description.journalRegisteredClass | scopus | - |
dc.relation.journalResearchArea | Gastroenterology & Hepatology | - |
dc.relation.journalWebOfScienceCategory | Gastroenterology & Hepatology | - |
dc.subject.keywordPlus | E-ANTIGEN SEROCONVERSION | - |
dc.subject.keywordPlus | LIVER-TRANSPLANTATION | - |
dc.subject.keywordPlus | ACUTE EXACERBATION | - |
dc.subject.keywordPlus | VIRUS INFECTION | - |
dc.subject.keywordPlus | YMDD VARIANTS | - |
dc.subject.keywordPlus | THERAPY | - |
dc.subject.keywordPlus | POLYMERASE | - |
dc.subject.keywordPlus | MUTATION | - |
dc.subject.keywordPlus | HBV | - |
dc.subject.keywordPlus | DNA | - |
dc.subject.keywordAuthor | Chronic hepatitis B | - |
dc.subject.keywordAuthor | Lamivudine | - |
dc.subject.keywordAuthor | Adefovir | - |
dc.subject.keywordAuthor | Treatment efficacy | - |
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