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Antiviral efficacy of adefovir dipivoxil versus lamivudine in patients with chronic hepatitis B sequentially treated with lamivudine and adefovir due to lamivudine resistance

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dc.contributor.authorSeo, Yeon Seok-
dc.contributor.authorKim, Ji Hoon-
dc.contributor.authorYeon, Jong Eun-
dc.contributor.authorPark, Jong-Jae-
dc.contributor.authorKim, Jae Seon-
dc.contributor.authorByun, Kwan Soo-
dc.contributor.authorBak, Young-Tae-
dc.contributor.authorLee, Chang Hong-
dc.date.available2020-11-03T11:49:35Z-
dc.date.issued2007-08-
dc.identifier.issn1007-9327-
dc.identifier.issn2219-2840-
dc.identifier.urihttps://scholarworks.korea.ac.kr/kumedicine/handle/2020.sw.kumedicine/17795-
dc.description.abstractAIM: To compare the antiviral efficacy of adefovir (ADV) in lamivudine (LMV)-resistant patients with LMV treatment in nucleoside-naïve patients, using serum samples collected sequentially during the course of treatment progressing from LMV to ADV. METHODS: Forty-four patients with chronic hepatitis B (CHB) were included. The patients were initially treated with LMV and then switched to ADV when LMV resistance developed. Antiviral efficacy was assessed by measuring the following: reduction in serum HBV DNA from baseline, HBV DNA negative conversion (defined as HBV DNA being undectable by the hybridization assay), and HBV DNA response (either HBV DNA level ≤ 105 copies/mL or a ≥ 2 log10 reduction from baseline HBV DNA level). RESULTS: After two and six months of treatment, HBV DNA reduction was greater with LMV compared to ADV treatment (P = 0.021). HBV DNA negative conversion rates were 64% and 27% after one month of LMV and ADV treatment respectively (P = 0.001). Similarly, HBV DNA response rates were 74% and 51% after two months of LMV and ADV treatment respectively (P = 0.026). The time taken to HBV DNA negative conversion and to HBV DNA response were both delayed in ADV treatment compared with LMV. CONCLUSION: The antiviral efficacy of ADV in LMV-resistant patients is slower and less potent than that with LMV in nucleoside-naïve patients during the early course of treatment.-
dc.format.extent8-
dc.language영어-
dc.language.isoENG-
dc.publisherBaishideng Publishing Group-
dc.titleAntiviral efficacy of adefovir dipivoxil versus lamivudine in patients with chronic hepatitis B sequentially treated with lamivudine and adefovir due to lamivudine resistance-
dc.typeArticle-
dc.publisher.location미국-
dc.identifier.doi10.3748/wjg.v13.i30.4072-
dc.identifier.scopusid2-s2.0-34548240700-
dc.identifier.wosid000248801300006-
dc.identifier.bibliographicCitationWorld Journal of Gastroenterology, v.13, no.30, pp 4072 - 4079-
dc.citation.titleWorld Journal of Gastroenterology-
dc.citation.volume13-
dc.citation.number30-
dc.citation.startPage4072-
dc.citation.endPage4079-
dc.type.docTypeArticle-
dc.description.isOpenAccessN-
dc.description.journalRegisteredClassscopus-
dc.relation.journalResearchAreaGastroenterology & Hepatology-
dc.relation.journalWebOfScienceCategoryGastroenterology & Hepatology-
dc.subject.keywordPlusE-ANTIGEN SEROCONVERSION-
dc.subject.keywordPlusLIVER-TRANSPLANTATION-
dc.subject.keywordPlusACUTE EXACERBATION-
dc.subject.keywordPlusVIRUS INFECTION-
dc.subject.keywordPlusYMDD VARIANTS-
dc.subject.keywordPlusTHERAPY-
dc.subject.keywordPlusPOLYMERASE-
dc.subject.keywordPlusMUTATION-
dc.subject.keywordPlusHBV-
dc.subject.keywordPlusDNA-
dc.subject.keywordAuthorChronic hepatitis B-
dc.subject.keywordAuthorLamivudine-
dc.subject.keywordAuthorAdefovir-
dc.subject.keywordAuthorTreatment efficacy-
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Seo, Yeon Seok
Anam Hospital (Department of Gastroenterology and Hepatology, Anam Hospital)
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