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Cited 2 time in webofscience Cited 4 time in scopus
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Clinical outcomes of chronic hepatitis B patients with persistently detectable serum hepatitis B virus DNA during lamivudine therapy

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dc.contributor.authorKim, Ji H.-
dc.contributor.authorYu, Sang K.-
dc.contributor.authorSeo, Yeon S.-
dc.contributor.authorYim, Hyung J.-
dc.contributor.authorYeon, Jong E.-
dc.contributor.authorPark, Jong J.-
dc.contributor.authorKim, Jae S.-
dc.contributor.authorBak, Young T.-
dc.contributor.authorLee, Chang H.-
dc.contributor.authorByun, Kwan S.-
dc.date.available2020-11-03T11:49:56Z-
dc.date.created2020-10-17-
dc.date.issued2007-08-
dc.identifier.issn0815-9319-
dc.identifier.urihttps://scholarworks.korea.ac.kr/kumedicine/handle/2020.sw.kumedicine/17817-
dc.description.abstractBackground and Aim: A small proportion of chronic hepatitis B patients have persistently detectable serum hepatitis B virus (HBV) DNA despite lamivudine therapy. The incidence and clinical outcomes of patients who persistently have detectable serum HBV-DNA during lamivudine therapy was investigated. Method: We enrolled 221 chronic hepatitis B patients who underwent lamivudine therapy for more than 6 months. Among them, 180 were HBeAg positive. Serum HBV-DNA, HBeAg, anti-HBe and alanine aminotransferase (ALT) levels were serially monitored. The study groups were defined, using a hybridization assay, as patients with reductions in serum HBV-DNA below the detectable level (group I) or patients with persistently detectable serum HBV-DNA (group II) during the initial 6 months of lamivudine therapy. Results: The incidence of patients who had persistently detectable HBV-DNA was 7.7%. After the first year, the rates of viral breakthrough, HBeAg loss and serum ALT normalization of group I versus group II were 21% versus 63%, 38% versus 0%, and 71% versus 28%, respectively (P < 0.001). The login reduction of serum HBV-DNA at 6 months was -4.58 log(10) for group I and -1.97 log(10) for group II (P < 0.001, bDNA assay). There were no pretreatment lamivudine-resistant mutants in group II. Conclusion: Lamivudine had little effect on serum HBV-DNA suppression, viral breakthrough suppression and rate of HBeAg loss and ALT normalization in chronic hepatitis B patients with persistently detectable serum HBV-DNA during the initial 6 months of therapy. Early termination of lamivudine therapy is advocated for these patients.-
dc.language영어-
dc.publisherWILEY-
dc.subjectE-ANTIGEN SEROCONVERSION-
dc.subjectTERM FOLLOW-UP-
dc.subjectINTERFERON-ALFA-
dc.subjectYMDD VARIANTS-
dc.subjectRESISTANCE-
dc.subjectEXPERIENCE-
dc.subjectINFECTION-
dc.subjectEMERGENCE-
dc.subjectTRIAL-
dc.titleClinical outcomes of chronic hepatitis B patients with persistently detectable serum hepatitis B virus DNA during lamivudine therapy-
dc.typeArticle-
dc.contributor.affiliatedAuthorKim, Ji H.-
dc.contributor.affiliatedAuthorSeo, Yeon S.-
dc.contributor.affiliatedAuthorYeon, Jong E.-
dc.contributor.affiliatedAuthorPark, Jong J.-
dc.contributor.affiliatedAuthorKim, Jae S.-
dc.identifier.doi10.1111/j.1440-1746.2007.04921.x-
dc.identifier.scopusid2-s2.0-34547652163-
dc.identifier.wosid000248544200013-
dc.identifier.bibliographicCitationJOURNAL OF GASTROENTEROLOGY AND HEPATOLOGY, v.22, no.8, pp.1220 - 1225-
dc.relation.isPartOfJOURNAL OF GASTROENTEROLOGY AND HEPATOLOGY-
dc.citation.titleJOURNAL OF GASTROENTEROLOGY AND HEPATOLOGY-
dc.citation.volume22-
dc.citation.number8-
dc.citation.startPage1220-
dc.citation.endPage1225-
dc.type.rimsART-
dc.type.docTypeArticle-
dc.description.journalClass1-
dc.description.journalRegisteredClassscie-
dc.description.journalRegisteredClassscopus-
dc.relation.journalResearchAreaGastroenterology & Hepatology-
dc.relation.journalWebOfScienceCategoryGastroenterology & Hepatology-
dc.subject.keywordPlusE-ANTIGEN SEROCONVERSION-
dc.subject.keywordPlusTERM FOLLOW-UP-
dc.subject.keywordPlusINTERFERON-ALFA-
dc.subject.keywordPlusYMDD VARIANTS-
dc.subject.keywordPlusRESISTANCE-
dc.subject.keywordPlusEXPERIENCE-
dc.subject.keywordPlusINFECTION-
dc.subject.keywordPlusEMERGENCE-
dc.subject.keywordPlusTRIAL-
dc.subject.keywordAuthorchronic hepatitis 3-
dc.subject.keywordAuthorhepatitis B virus DNA-
dc.subject.keywordAuthorlamivudine-
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Anam Hospital (Department of Gastroenterology and Hepatology, Anam Hospital)
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