Reduction of renal fibrosis as a result of liposome encapsulated clodronate induced macrophage depletion after unilateral ureteral obstruction in rats
DC Field | Value | Language |
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dc.contributor.author | Sung, Su Ah | - |
dc.contributor.author | Jo, Sang Kyung | - |
dc.contributor.author | Cho, Won Yong | - |
dc.contributor.author | Won, Nam Hee | - |
dc.contributor.author | Kim, Hyoung Kyu | - |
dc.date.available | 2020-11-03T13:44:26Z | - |
dc.date.issued | 2007 | - |
dc.identifier.issn | 1660-2129 | - |
dc.identifier.uri | https://scholarworks.korea.ac.kr/kumedicine/handle/2020.sw.kumedicine/18432 | - |
dc.description.abstract | Background/Aim: Macrophages have been thought to play a role in renal tubulointerstitial fibrosis; recent reports have demonstrated an antifibrotic effect of macrophages in late-stage renal fibrosis. Liposome-encapsulated clodronate (LC) produces a selective and systemic depletion of phagocytic macrophages in vivo. To study the role of initial infiltrating macrophages in renal fibrosis, we compared the effects of pretreatment with LC and a liposome vehicle for control of the severity of renal fibrosis in a unilateral ureteral obstruction (UUO) rat model. Methods: One day after a single intravenous injection of LC or liposome vehicle, the rats underwent UUO. Following 1, 5, and 14 days, the kidneys were examined to evaluate macrophage infiltration and renal fibrosis. Results: LC depleted macrophages systemically and reduced renal fibrosis associated with UUO; this beneficial effect was accompanied by a decrease of transforming growth factor beta mRNA expression. The osteopontinex-pression was also reduced by pretreatment with LC. Conclusion: Initial interstitial infiltration of macrophages contributes to tubulointerstitial fibrosis in UUO. Copyright (c) 2007 S. Karger AG, Basel. | - |
dc.language | 영어 | - |
dc.language.iso | ENG | - |
dc.publisher | KARGER | - |
dc.title | Reduction of renal fibrosis as a result of liposome encapsulated clodronate induced macrophage depletion after unilateral ureteral obstruction in rats | - |
dc.type | Article | - |
dc.publisher.location | 스위스 | - |
dc.identifier.doi | 10.1159/000096859 | - |
dc.identifier.scopusid | 2-s2.0-33845734736 | - |
dc.identifier.wosid | 000242372500001 | - |
dc.identifier.bibliographicCitation | NEPHRON EXPERIMENTAL NEPHROLOGY, v.105, no.1, pp E1 - E9 | - |
dc.citation.title | NEPHRON EXPERIMENTAL NEPHROLOGY | - |
dc.citation.volume | 105 | - |
dc.citation.number | 1 | - |
dc.citation.startPage | E1 | - |
dc.citation.endPage | E9 | - |
dc.type.docType | Article | - |
dc.description.isOpenAccess | N | - |
dc.description.journalRegisteredClass | scie | - |
dc.description.journalRegisteredClass | scopus | - |
dc.relation.journalResearchArea | Urology & Nephrology | - |
dc.relation.journalWebOfScienceCategory | Urology & Nephrology | - |
dc.subject.keywordPlus | EXPERIMENTAL HYDRONEPHROSIS | - |
dc.subject.keywordPlus | MOUSE | - |
dc.subject.keywordPlus | MICE | - |
dc.subject.keywordPlus | INFILTRATION | - |
dc.subject.keywordPlus | NEPHROPATHY | - |
dc.subject.keywordPlus | APOPTOSIS | - |
dc.subject.keywordPlus | CELLS | - |
dc.subject.keywordAuthor | liposome-encapsulated clodronate | - |
dc.subject.keywordAuthor | macrophages | - |
dc.subject.keywordAuthor | unilateral ureteral obstruction | - |
dc.subject.keywordAuthor | renal fibrosis | - |
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