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Reduction of renal fibrosis as a result of liposome encapsulated clodronate induced macrophage depletion after unilateral ureteral obstruction in rats

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dc.contributor.authorSung, Su Ah-
dc.contributor.authorJo, Sang Kyung-
dc.contributor.authorCho, Won Yong-
dc.contributor.authorWon, Nam Hee-
dc.contributor.authorKim, Hyoung Kyu-
dc.date.available2020-11-03T13:44:26Z-
dc.date.issued2007-
dc.identifier.issn1660-2129-
dc.identifier.urihttps://scholarworks.korea.ac.kr/kumedicine/handle/2020.sw.kumedicine/18432-
dc.description.abstractBackground/Aim: Macrophages have been thought to play a role in renal tubulointerstitial fibrosis; recent reports have demonstrated an antifibrotic effect of macrophages in late-stage renal fibrosis. Liposome-encapsulated clodronate (LC) produces a selective and systemic depletion of phagocytic macrophages in vivo. To study the role of initial infiltrating macrophages in renal fibrosis, we compared the effects of pretreatment with LC and a liposome vehicle for control of the severity of renal fibrosis in a unilateral ureteral obstruction (UUO) rat model. Methods: One day after a single intravenous injection of LC or liposome vehicle, the rats underwent UUO. Following 1, 5, and 14 days, the kidneys were examined to evaluate macrophage infiltration and renal fibrosis. Results: LC depleted macrophages systemically and reduced renal fibrosis associated with UUO; this beneficial effect was accompanied by a decrease of transforming growth factor beta mRNA expression. The osteopontinex-pression was also reduced by pretreatment with LC. Conclusion: Initial interstitial infiltration of macrophages contributes to tubulointerstitial fibrosis in UUO. Copyright (c) 2007 S. Karger AG, Basel.-
dc.language영어-
dc.language.isoENG-
dc.publisherKARGER-
dc.titleReduction of renal fibrosis as a result of liposome encapsulated clodronate induced macrophage depletion after unilateral ureteral obstruction in rats-
dc.typeArticle-
dc.publisher.location스위스-
dc.identifier.doi10.1159/000096859-
dc.identifier.scopusid2-s2.0-33845734736-
dc.identifier.wosid000242372500001-
dc.identifier.bibliographicCitationNEPHRON EXPERIMENTAL NEPHROLOGY, v.105, no.1, pp E1 - E9-
dc.citation.titleNEPHRON EXPERIMENTAL NEPHROLOGY-
dc.citation.volume105-
dc.citation.number1-
dc.citation.startPageE1-
dc.citation.endPageE9-
dc.type.docTypeArticle-
dc.description.isOpenAccessN-
dc.description.journalRegisteredClassscie-
dc.description.journalRegisteredClassscopus-
dc.relation.journalResearchAreaUrology & Nephrology-
dc.relation.journalWebOfScienceCategoryUrology & Nephrology-
dc.subject.keywordPlusEXPERIMENTAL HYDRONEPHROSIS-
dc.subject.keywordPlusMOUSE-
dc.subject.keywordPlusMICE-
dc.subject.keywordPlusINFILTRATION-
dc.subject.keywordPlusNEPHROPATHY-
dc.subject.keywordPlusAPOPTOSIS-
dc.subject.keywordPlusCELLS-
dc.subject.keywordAuthorliposome-encapsulated clodronate-
dc.subject.keywordAuthormacrophages-
dc.subject.keywordAuthorunilateral ureteral obstruction-
dc.subject.keywordAuthorrenal fibrosis-
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1. Basic Science > Department of Pathology > 1. Journal Articles
2. Clinical Science > Department of Nephrology and Hypertension > 1. Journal Articles

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Kim, Hyoung Kyu
Anam Hospital (Department of Nephrology and Hypertension, Anam Hospital)
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