Peripheral mGluR5 antagonist attenuated craniofacial muscle pain and inflammation but not mGluR1 antagonist in lightly anesthetized rats
DC Field | Value | Language |
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dc.contributor.author | Lee, Ho Jeong | - |
dc.contributor.author | Choi, Hyo Soon | - |
dc.contributor.author | Ju, Jin Sook | - |
dc.contributor.author | Bae, Yong Chul | - |
dc.contributor.author | Kim, Sung Kyo | - |
dc.contributor.author | Yoon, Young Wook | - |
dc.contributor.author | Ahn, Dong Kuk | - |
dc.date.available | 2020-11-03T13:46:48Z | - |
dc.date.issued | 2006-10 | - |
dc.identifier.issn | 0361-9230 | - |
dc.identifier.issn | 1873-2747 | - |
dc.identifier.uri | https://scholarworks.korea.ac.kr/kumedicine/handle/2020.sw.kumedicine/18577 | - |
dc.description.abstract | The present study investigated the role of peripheral group I metabotropic glutamate receptors (mGluRs) in MO-induced nociceptive behaviour and inflammation in the masseter muscles of lightly anesthetized rats. Experiments were carried out on male Sprague-Dawley rats weighing 300-400 g. After initial anesthesia with sodium pentobarbital (40 mg/kg, i.p.), one femoral vein was cannulated and connected to an infusion pump for intravenous infusion of sodium pentobarbital. The rate of infusion was adjusted to provide a constant level of anesthesia. Mustard oil (MO, 30 mu l) was injected into the mid-region of the left masseter muscle via a 30-gauge needle over 10 s. After 30 mu l injection of 5, 10, 15, or 20% MO into the masseter muscle, the total number of hindpaw shaking behaviour and extravasated Evans' blue dye concentration in the masseter muscle were significantly higher in the MO-treated group in a dose-dependent manner compared with the vehicle (mineral oil)-treated group. Intramuscular pretreatment with 3 or 5% lidocaine reduced MO-induced hindpaw shaking behaviour and increases in extravasated Evans' blue dye concentration. Intramuscular pretreatment with 5 mM MCPG, non-selective group I/II mGluR antagonist, or MPEP, a selective group I mGluR5 antagonist, produced a significant attenuation of MO-induced hindpaw shaking behaviour and increases in extravasated Evans' blue dye concentration in the masseter muscle while LY367385, a selective group I mGluR1 antagonist, did not affect MO-induced nociceptive behaviour and inflammation in the masseter muscle. These results indicate that peripheral mGluR5 plays important role in mediating MO-induced nociceptive behaviour and inflammation in the craniofacial muscle. (c) 2006 Elsevier Inc. All rights reserved. | - |
dc.format.extent | 8 | - |
dc.language | 영어 | - |
dc.language.iso | ENG | - |
dc.publisher | Elsevier BV | - |
dc.title | Peripheral mGluR5 antagonist attenuated craniofacial muscle pain and inflammation but not mGluR1 antagonist in lightly anesthetized rats | - |
dc.type | Article | - |
dc.publisher.location | 영국 | - |
dc.identifier.doi | 10.1016/j.brainresbull.2005.09.021 | - |
dc.identifier.scopusid | 2-s2.0-33749256670 | - |
dc.identifier.wosid | 000241546500013 | - |
dc.identifier.bibliographicCitation | Brain Research Bulletin, v.70, no.4-6, pp 378 - 385 | - |
dc.citation.title | Brain Research Bulletin | - |
dc.citation.volume | 70 | - |
dc.citation.number | 4-6 | - |
dc.citation.startPage | 378 | - |
dc.citation.endPage | 385 | - |
dc.type.docType | Article | - |
dc.description.isOpenAccess | N | - |
dc.description.journalRegisteredClass | scopus | - |
dc.relation.journalResearchArea | Neurosciences & Neurology | - |
dc.relation.journalWebOfScienceCategory | Neurosciences | - |
dc.subject.keywordPlus | OROFACIAL FORMALIN TEST | - |
dc.subject.keywordPlus | METABOTROPIC GLUTAMATE RECEPTORS | - |
dc.subject.keywordPlus | TEMPOROMANDIBULAR-JOINT | - |
dc.subject.keywordPlus | MUSTARD-OIL | - |
dc.subject.keywordPlus | NEUROGENIC INFLAMMATION | - |
dc.subject.keywordPlus | BEHAVIORAL-ASSESSMENT | - |
dc.subject.keywordPlus | MECHANICAL ALLODYNIA | - |
dc.subject.keywordPlus | IRRITANT APPLICATION | - |
dc.subject.keywordPlus | HUMAN JAW | - |
dc.subject.keywordPlus | SKIN | - |
dc.subject.keywordAuthor | antinociception | - |
dc.subject.keywordAuthor | muscle inflammation | - |
dc.subject.keywordAuthor | muscle pain | - |
dc.subject.keywordAuthor | nociceptive behaviour | - |
dc.subject.keywordAuthor | peripheral mGluR | - |
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