Weight gain associated with the alpha(2a)-adrenergic receptor-1291 C/G polymorphism and olanzapine treatment
DC Field | Value | Language |
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dc.contributor.author | Park, Young-Min | - |
dc.contributor.author | Chung, Young-Cho | - |
dc.contributor.author | Lee, Seung-Hwan | - |
dc.contributor.author | Lee, Kaug-Joon | - |
dc.contributor.author | Kim, Hyun | - |
dc.contributor.author | Byun, Young-Chan | - |
dc.contributor.author | Lim, Se-Won | - |
dc.contributor.author | Paik, Jong-Woo | - |
dc.contributor.author | Lee, Heon-Jeong | - |
dc.date.available | 2020-11-03T13:50:39Z | - |
dc.date.issued | 2006-06-05 | - |
dc.identifier.issn | 1552-4841 | - |
dc.identifier.issn | 1552-485X | - |
dc.identifier.uri | https://scholarworks.korea.ac.kr/kumedicine/handle/2020.sw.kumedicine/18777 | - |
dc.description.abstract | Weight gain can be an adverse effect of antipsychotics and is an important factor for long-term health and treatment compliance. Many reports have shown that the alpha(2)-adrenergic receptor may be related to eating behaviors or lipolytic activities, both associated with body weight change. We hypothesized that there might be a relationship between the (alpha 2a)-adrenergic receptor -1291 C/G polymorphism. and olanzapine-induced weight gain. A group of 62 Korean schizophrenic patients participated in a study; weight and height measurements were obtained prior to starting olanzapine and measured again after long-term treatment. Genotyping for the -1291 C/G polymorphism was performed on all participants. Body weight changes from baseline to endpoint were significantly associated with genotypes (P = 0.028). The frequency of the G allele was significantly higher in subjects who had severe weight gain (defined as a more than 10% weight gain from baseline) compared to subjects who did not have extreme weight gain (less than 10% weight gain from baseline) (X-2 = 6.120, P = 0.013; OR = 2.58, 95% CI = 1.21-5.51). Therefore, the findings from this study support a relationship between the -1291 C/ G polymorphism of the alpha(2a)-adrenergic receptor and weight gain in Korean schizophrenic patients receiving olanzapine treatment. (c) 2006 Wiley-Liss, Inc. | - |
dc.format.extent | 4 | - |
dc.language | 영어 | - |
dc.language.iso | ENG | - |
dc.publisher | WILEY | - |
dc.title | Weight gain associated with the alpha(2a)-adrenergic receptor-1291 C/G polymorphism and olanzapine treatment | - |
dc.type | Article | - |
dc.publisher.location | 미국 | - |
dc.identifier.doi | 10.1002/ajmg.b.30311 | - |
dc.identifier.scopusid | 2-s2.0-33745013199 | - |
dc.identifier.wosid | 000238054200012 | - |
dc.identifier.bibliographicCitation | AMERICAN JOURNAL OF MEDICAL GENETICS PART B-NEUROPSYCHIATRIC GENETICS, v.141B, no.4, pp 394 - 397 | - |
dc.citation.title | AMERICAN JOURNAL OF MEDICAL GENETICS PART B-NEUROPSYCHIATRIC GENETICS | - |
dc.citation.volume | 141B | - |
dc.citation.number | 4 | - |
dc.citation.startPage | 394 | - |
dc.citation.endPage | 397 | - |
dc.type.docType | Article | - |
dc.description.isOpenAccess | N | - |
dc.description.journalRegisteredClass | scie | - |
dc.description.journalRegisteredClass | scopus | - |
dc.relation.journalResearchArea | Genetics & Heredity | - |
dc.relation.journalResearchArea | Psychiatry | - |
dc.relation.journalWebOfScienceCategory | Genetics & Heredity | - |
dc.relation.journalWebOfScienceCategory | Psychiatry | - |
dc.subject.keywordPlus | ATYPICAL ANTIPSYCHOTICS | - |
dc.subject.keywordPlus | GENETIC-VARIATION | - |
dc.subject.keywordPlus | PROMOTER REGION | - |
dc.subject.keywordPlus | IDENTIFICATION | - |
dc.subject.keywordPlus | DELETION | - |
dc.subject.keywordAuthor | olanzapine | - |
dc.subject.keywordAuthor | weight gain | - |
dc.subject.keywordAuthor | alpha(2a)-adrenergic receptor | - |
dc.subject.keywordAuthor | polymorphisms | - |
dc.subject.keywordAuthor | schizophrenia | - |
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