A prospective study comparing the efficacy of early administration of terlipressin and somatostatin for the control of acute variceal bleeding in patients with cirrhosis
DC Field | Value | Language |
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dc.contributor.author | Seo Y.S. | - |
dc.contributor.author | Um S.H. | - |
dc.contributor.author | Hyun J.J. | - |
dc.contributor.author | Kim Y.H. | - |
dc.contributor.author | Park S. | - |
dc.contributor.author | Keum B.R. | - |
dc.contributor.author | Kim Y.S. | - |
dc.contributor.author | Jeen Y.T. | - |
dc.contributor.author | Lee H.S. | - |
dc.contributor.author | Chun H.J. | - |
dc.contributor.author | Lee S.W. | - |
dc.contributor.author | Choi J.H. | - |
dc.contributor.author | Kim C.D. | - |
dc.contributor.author | Ryu H.S. | - |
dc.date.available | 2020-11-03T14:50:29Z | - |
dc.date.issued | 2006-09 | - |
dc.identifier.issn | 1738-222X | - |
dc.identifier.uri | https://scholarworks.korea.ac.kr/kumedicine/handle/2020.sw.kumedicine/19250 | - |
dc.description.abstract | BACKGROUND/AIMS: Terlipressin and somatostatin decrease portal venous pressure and they are used for the treatment of variceal bleeding. However, only a few studies have compared the efficacy of these drugs in combination with other procedures for hemostasis. Therefore, we performed a prospective study to compare the efficacy of terlipressin and somatostatin for controlling acute variceal bleeding when used in combination with other procedures for hemostasis. METHODS: A total of 98 patients, who presented with variceal bleeding from September 2003 to May 2005, were randomly divided into the somatostatin group or terlipressin group. We compared the 5-day failure rate (defined as failure to control bleeding, rebleeding or death within 5 days of admission) and the 6-week mortality. The prognostic factors for 5-day failure and 6-week mortality were also evaluated. RESULTS: There were no differences in baseline characteristics between the two groups. The overall 5-day failure rate and the cumulative 6-week mortality were 16.3% and 15.8%, respectively. The five-day failure rate and the cumulative 6-week mortality were not significantly different between the somatostatin and terlipressin groups. Hepatocellular carcinoma, the baseline serum creatinine level and endoscopic treatment for hemostasis were the significant predictors of 5-day failure; the baseline serum creatinine level was the predictor of 6-week mortality. CONCLUSIONS: Both somatostatin and terlipressin were effective and showed comparable efficacy for the control of the acute variceal bleeding in the setting of a combined therapeutic approach. The baseline serum creatinine level may be a significant predictor for patient failure at 5 days and the 6-week mortality. | - |
dc.format.extent | 12 | - |
dc.language | 한국어 | - |
dc.language.iso | KOR | - |
dc.title | A prospective study comparing the efficacy of early administration of terlipressin and somatostatin for the control of acute variceal bleeding in patients with cirrhosis | - |
dc.type | Article | - |
dc.publisher.location | 대한민국 | - |
dc.identifier.scopusid | 2-s2.0-48149112172 | - |
dc.identifier.bibliographicCitation | The Korean journal of hepatology, v.12, no.3, pp 373 - 384 | - |
dc.citation.title | The Korean journal of hepatology | - |
dc.citation.volume | 12 | - |
dc.citation.number | 3 | - |
dc.citation.startPage | 373 | - |
dc.citation.endPage | 384 | - |
dc.type.docType | Article | - |
dc.identifier.kciid | ART001172506 | - |
dc.description.isOpenAccess | N | - |
dc.description.journalRegisteredClass | scopus | - |
dc.description.journalRegisteredClass | kciCandi | - |
dc.subject.keywordPlus | drug derivative | - |
dc.subject.keywordPlus | lypressin | - |
dc.subject.keywordPlus | somatostatin | - |
dc.subject.keywordPlus | terlipressin | - |
dc.subject.keywordPlus | vasoconstrictor agent | - |
dc.subject.keywordPlus | acute disease | - |
dc.subject.keywordPlus | aged | - |
dc.subject.keywordPlus | article | - |
dc.subject.keywordPlus | bleeding | - |
dc.subject.keywordPlus | clinical trial | - |
dc.subject.keywordPlus | controlled clinical trial | - |
dc.subject.keywordPlus | controlled study | - |
dc.subject.keywordPlus | esophagus varices | - |
dc.subject.keywordPlus | female | - |
dc.subject.keywordPlus | gastrointestinal hemorrhage | - |
dc.subject.keywordPlus | hemostasis | - |
dc.subject.keywordPlus | human | - |
dc.subject.keywordPlus | liver | - |
dc.subject.keywordPlus | liver cell carcinoma | - |
dc.subject.keywordPlus | liver cirrhosis | - |
dc.subject.keywordPlus | liver disease | - |
dc.subject.keywordPlus | liver tumor | - |
dc.subject.keywordPlus | male | - |
dc.subject.keywordPlus | middle aged | - |
dc.subject.keywordPlus | multivariate analysis | - |
dc.subject.keywordPlus | randomized controlled trial | - |
dc.subject.keywordPlus | varicosis | - |
dc.subject.keywordPlus | vascularization | - |
dc.subject.keywordPlus | Acute Disease | - |
dc.subject.keywordPlus | Aged | - |
dc.subject.keywordPlus | Carcinoma, Hepatocellular | - |
dc.subject.keywordPlus | Esophageal and Gastric Varices | - |
dc.subject.keywordPlus | Female | - |
dc.subject.keywordPlus | Gastrointestinal Hemorrhage | - |
dc.subject.keywordPlus | Hemorrhage | - |
dc.subject.keywordPlus | Hemostasis, Endoscopic | - |
dc.subject.keywordPlus | Humans | - |
dc.subject.keywordPlus | Liver | - |
dc.subject.keywordPlus | Liver Cirrhosis | - |
dc.subject.keywordPlus | Liver Diseases | - |
dc.subject.keywordPlus | Liver Neoplasms | - |
dc.subject.keywordPlus | Lysine Vasopressin | - |
dc.subject.keywordPlus | Male | - |
dc.subject.keywordPlus | Middle Aged | - |
dc.subject.keywordPlus | Multivariate Analysis | - |
dc.subject.keywordPlus | Somatostatin | - |
dc.subject.keywordPlus | Varicose Veins | - |
dc.subject.keywordPlus | Vasoconstrictor Agents | - |
dc.subject.keywordAuthor | 간경변증 | - |
dc.subject.keywordAuthor | 정맥류 출혈 | - |
dc.subject.keywordAuthor | 지혈 | - |
dc.subject.keywordAuthor | Liver cirrhosis | - |
dc.subject.keywordAuthor | Variceal bleeding | - |
dc.subject.keywordAuthor | Hemostasis | - |
dc.subject.keywordAuthor | Terlipressin | - |
dc.subject.keywordAuthor | Somatostatin | - |
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