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A prospective study comparing the efficacy of early administration of terlipressin and somatostatin for the control of acute variceal bleeding in patients with cirrhosis

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dc.contributor.authorSeo Y.S.-
dc.contributor.authorUm S.H.-
dc.contributor.authorHyun J.J.-
dc.contributor.authorKim Y.H.-
dc.contributor.authorPark S.-
dc.contributor.authorKeum B.R.-
dc.contributor.authorKim Y.S.-
dc.contributor.authorJeen Y.T.-
dc.contributor.authorLee H.S.-
dc.contributor.authorChun H.J.-
dc.contributor.authorLee S.W.-
dc.contributor.authorChoi J.H.-
dc.contributor.authorKim C.D.-
dc.contributor.authorRyu H.S.-
dc.date.available2020-11-03T14:50:29Z-
dc.date.issued2006-09-
dc.identifier.issn1738-222X-
dc.identifier.urihttps://scholarworks.korea.ac.kr/kumedicine/handle/2020.sw.kumedicine/19250-
dc.description.abstractBACKGROUND/AIMS: Terlipressin and somatostatin decrease portal venous pressure and they are used for the treatment of variceal bleeding. However, only a few studies have compared the efficacy of these drugs in combination with other procedures for hemostasis. Therefore, we performed a prospective study to compare the efficacy of terlipressin and somatostatin for controlling acute variceal bleeding when used in combination with other procedures for hemostasis. METHODS: A total of 98 patients, who presented with variceal bleeding from September 2003 to May 2005, were randomly divided into the somatostatin group or terlipressin group. We compared the 5-day failure rate (defined as failure to control bleeding, rebleeding or death within 5 days of admission) and the 6-week mortality. The prognostic factors for 5-day failure and 6-week mortality were also evaluated. RESULTS: There were no differences in baseline characteristics between the two groups. The overall 5-day failure rate and the cumulative 6-week mortality were 16.3% and 15.8%, respectively. The five-day failure rate and the cumulative 6-week mortality were not significantly different between the somatostatin and terlipressin groups. Hepatocellular carcinoma, the baseline serum creatinine level and endoscopic treatment for hemostasis were the significant predictors of 5-day failure; the baseline serum creatinine level was the predictor of 6-week mortality. CONCLUSIONS: Both somatostatin and terlipressin were effective and showed comparable efficacy for the control of the acute variceal bleeding in the setting of a combined therapeutic approach. The baseline serum creatinine level may be a significant predictor for patient failure at 5 days and the 6-week mortality.-
dc.format.extent12-
dc.language한국어-
dc.language.isoKOR-
dc.titleA prospective study comparing the efficacy of early administration of terlipressin and somatostatin for the control of acute variceal bleeding in patients with cirrhosis-
dc.typeArticle-
dc.publisher.location대한민국-
dc.identifier.scopusid2-s2.0-48149112172-
dc.identifier.bibliographicCitationThe Korean journal of hepatology, v.12, no.3, pp 373 - 384-
dc.citation.titleThe Korean journal of hepatology-
dc.citation.volume12-
dc.citation.number3-
dc.citation.startPage373-
dc.citation.endPage384-
dc.type.docTypeArticle-
dc.identifier.kciidART001172506-
dc.description.isOpenAccessN-
dc.description.journalRegisteredClassscopus-
dc.description.journalRegisteredClasskciCandi-
dc.subject.keywordPlusdrug derivative-
dc.subject.keywordPluslypressin-
dc.subject.keywordPlussomatostatin-
dc.subject.keywordPlusterlipressin-
dc.subject.keywordPlusvasoconstrictor agent-
dc.subject.keywordPlusacute disease-
dc.subject.keywordPlusaged-
dc.subject.keywordPlusarticle-
dc.subject.keywordPlusbleeding-
dc.subject.keywordPlusclinical trial-
dc.subject.keywordPluscontrolled clinical trial-
dc.subject.keywordPluscontrolled study-
dc.subject.keywordPlusesophagus varices-
dc.subject.keywordPlusfemale-
dc.subject.keywordPlusgastrointestinal hemorrhage-
dc.subject.keywordPlushemostasis-
dc.subject.keywordPlushuman-
dc.subject.keywordPlusliver-
dc.subject.keywordPlusliver cell carcinoma-
dc.subject.keywordPlusliver cirrhosis-
dc.subject.keywordPlusliver disease-
dc.subject.keywordPlusliver tumor-
dc.subject.keywordPlusmale-
dc.subject.keywordPlusmiddle aged-
dc.subject.keywordPlusmultivariate analysis-
dc.subject.keywordPlusrandomized controlled trial-
dc.subject.keywordPlusvaricosis-
dc.subject.keywordPlusvascularization-
dc.subject.keywordPlusAcute Disease-
dc.subject.keywordPlusAged-
dc.subject.keywordPlusCarcinoma, Hepatocellular-
dc.subject.keywordPlusEsophageal and Gastric Varices-
dc.subject.keywordPlusFemale-
dc.subject.keywordPlusGastrointestinal Hemorrhage-
dc.subject.keywordPlusHemorrhage-
dc.subject.keywordPlusHemostasis, Endoscopic-
dc.subject.keywordPlusHumans-
dc.subject.keywordPlusLiver-
dc.subject.keywordPlusLiver Cirrhosis-
dc.subject.keywordPlusLiver Diseases-
dc.subject.keywordPlusLiver Neoplasms-
dc.subject.keywordPlusLysine Vasopressin-
dc.subject.keywordPlusMale-
dc.subject.keywordPlusMiddle Aged-
dc.subject.keywordPlusMultivariate Analysis-
dc.subject.keywordPlusSomatostatin-
dc.subject.keywordPlusVaricose Veins-
dc.subject.keywordPlusVasoconstrictor Agents-
dc.subject.keywordAuthor간경변증-
dc.subject.keywordAuthor정맥류 출혈-
dc.subject.keywordAuthor지혈-
dc.subject.keywordAuthorLiver cirrhosis-
dc.subject.keywordAuthorVariceal bleeding-
dc.subject.keywordAuthorHemostasis-
dc.subject.keywordAuthorTerlipressin-
dc.subject.keywordAuthorSomatostatin-
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