대사증후군과 혈액학적 지표와의 연관성

Abstract

Background: Metabolic syndrome increases the risk of cardiovascular events as a result of the activation of inflammatory cytokines and thrombogenic factors. In this study, we investigated whether metabolic syndrome (MS) is related to red blood cell (RBC), white blood cell(WBC) and differential counts. Methods: We analyzed 399 subjects who participated in routine health check up from March to July 2004. 299 subjects whose hematologic parameters were within normal value were included finally. We measured their metabolic components and evaluated the relation of MS and hematologic parameters. Results: All results were adjusted for gender, age and smoking status. The counts of RBC and WBC were significantly higher in MS group(P<0.05), and especially the counts of WBC, neutrophil, and lymphocyte were higher in the male MS group. According to the number of metabolic component(0,1,2,3 and more than 4) the subjects were allocated in 5 groups. Especially, only in men the means of the counts of WBC, neutrophil, and lymphocyte were different significantly among these groups(P<0.05). As the number of metabolic component was increased, WBC, neutrophil, and lymphocyte were increased significantly(P<0.01). Conclusions: The metabolic syndrome is related to the counts of RBC and WBC, especially in male MS group, the counts of WBC, neutrophil, lymphocyte were higher. In men as the number of metabolic component was increased, the counts of WBC, neutrophil and lymphocyte were increased and there was the significant difference of them among the groups which were divided according to the number of metabolic component.