Selegiline potentiates the effects of EGb 761 in response to ischemic brain injury
DC Field | Value | Language |
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dc.contributor.author | Kwon Y.S. | - |
dc.contributor.author | Ann H.S. | - |
dc.contributor.author | Nabeshima T. | - |
dc.contributor.author | Shin E.J. | - |
dc.contributor.author | Kim W.K. | - |
dc.contributor.author | Jhoo J.H. | - |
dc.contributor.author | Jhoo W.K. | - |
dc.contributor.author | Wie M.B. | - |
dc.contributor.author | Kim Y.S. | - |
dc.contributor.author | Jang K.J. | - |
dc.contributor.author | Kim H.C. | - |
dc.date.available | 2020-11-03T17:51:41Z | - |
dc.date.issued | 2004 | - |
dc.identifier.issn | 0197-0186 | - |
dc.identifier.issn | 1872-9754 | - |
dc.identifier.uri | https://scholarworks.korea.ac.kr/kumedicine/handle/2020.sw.kumedicine/20857 | - |
dc.description.abstract | We evaluated whether combined treatment with selegiline, a selective MAO-B inhibitor, and EGb 761, a standard extract of Ginkgo biloba, has synergistic effects against ischemic reperfusion injury (IRI) in gerbils. Interestingly, we observed that pretreatment with EGb 761 significantly attenuated selegiline-induced hyperactivity. This finding paralleled striatal fos-related antigen immunoreactivity (FRA-IR) in mice. Four minutes of bilateral carotid artery occlusion caused substantial cell loss in the CA1 of the hippocampus 5 days post-ischemic insult. Pretreatment with EGb 761, with or without selegiline, significantly attenuated this neuronal loss. Combined treatment with EGb 761 plus selegiline was more efficacious in preventing this loss. Synaptosomal formations of protein carbonyl, lipid peroxidation (malondialdehyde (MDA) + 4-hydroxyalkenal (4-HDA)), and reactive oxygen species (ROS) in the hippocampus remained elevated 5 days post-ischemic insult. The antioxidant effects appeared to be most significant in the group treated with EGb 761 plus selegiline. This combined treatment produced more significant attenuation of IRI-induced alterations in intramitochondrial calcium accumulation, the mitochondrial transmembrane potential, and mitochondrial Mn-superoxide dismutase-like immunoreactivity (Mn-SOD-IR) than either treatment alone. Our results suggest that co-administration of EGb 761 and selegiline produces significant neuroprotective effects via suppression of oxidative stress and mitochondrial dysfunction without affecting neurological function. © 2003 Elsevier Ltd. All rights reserved. | - |
dc.format.extent | 14 | - |
dc.language | 영어 | - |
dc.language.iso | ENG | - |
dc.title | Selegiline potentiates the effects of EGb 761 in response to ischemic brain injury | - |
dc.type | Article | - |
dc.publisher.location | 영국 | - |
dc.identifier.doi | 10.1016/j.neuint.2003.10.005 | - |
dc.identifier.scopusid | 2-s2.0-11144356904 | - |
dc.identifier.bibliographicCitation | Neurochemistry International, v.45, no.1, pp 157 - 170 | - |
dc.citation.title | Neurochemistry International | - |
dc.citation.volume | 45 | - |
dc.citation.number | 1 | - |
dc.citation.startPage | 157 | - |
dc.citation.endPage | 170 | - |
dc.type.docType | Article | - |
dc.description.isOpenAccess | N | - |
dc.description.journalRegisteredClass | scopus | - |
dc.subject.keywordPlus | alkene derivative | - |
dc.subject.keywordPlus | carbonyl derivative | - |
dc.subject.keywordPlus | Ginkgo biloba extract | - |
dc.subject.keywordPlus | malonaldehyde | - |
dc.subject.keywordPlus | manganese superoxide dismutase | - |
dc.subject.keywordPlus | monoamine oxidase B inhibitor | - |
dc.subject.keywordPlus | reactive oxygen metabolite | - |
dc.subject.keywordPlus | selegiline | - |
dc.subject.keywordPlus | transcription factor Fra 1 | - |
dc.subject.keywordPlus | animal cell | - |
dc.subject.keywordPlus | animal experiment | - |
dc.subject.keywordPlus | animal model | - |
dc.subject.keywordPlus | article | - |
dc.subject.keywordPlus | brain ischemia | - |
dc.subject.keywordPlus | carotid artery obstruction | - |
dc.subject.keywordPlus | cell loss | - |
dc.subject.keywordPlus | controlled study | - |
dc.subject.keywordPlus | drug effect | - |
dc.subject.keywordPlus | drug efficacy | - |
dc.subject.keywordPlus | drug potentiation | - |
dc.subject.keywordPlus | drug response | - |
dc.subject.keywordPlus | gerbil | - |
dc.subject.keywordPlus | hyperactivity | - |
dc.subject.keywordPlus | immunoreactivity | - |
dc.subject.keywordPlus | lipid peroxidation | - |
dc.subject.keywordPlus | male | - |
dc.subject.keywordPlus | membrane potential | - |
dc.subject.keywordPlus | mitochondrion | - |
dc.subject.keywordPlus | mouse | - |
dc.subject.keywordPlus | nerve cell | - |
dc.subject.keywordPlus | nonhuman | - |
dc.subject.keywordPlus | priority journal | - |
dc.subject.keywordPlus | reperfusion injury | - |
dc.subject.keywordPlus | synaptosome | - |
dc.subject.keywordPlus | Animals | - |
dc.subject.keywordPlus | Brain | - |
dc.subject.keywordPlus | Brain Ischemia | - |
dc.subject.keywordPlus | Drug Synergism | - |
dc.subject.keywordPlus | Gerbillinae | - |
dc.subject.keywordPlus | Ginkgo biloba | - |
dc.subject.keywordPlus | Male | - |
dc.subject.keywordPlus | Mice | - |
dc.subject.keywordPlus | Mice, Inbred BALB C | - |
dc.subject.keywordPlus | Motor Activity | - |
dc.subject.keywordPlus | Plant Extracts | - |
dc.subject.keywordPlus | Reactive Oxygen Species | - |
dc.subject.keywordPlus | Selegiline | - |
dc.subject.keywordPlus | Gerbillinae | - |
dc.subject.keywordPlus | Ginkgo biloba | - |
dc.subject.keywordAuthor | Antioxidant and neuroprotective effects | - |
dc.subject.keywordAuthor | Behavioral effects | - |
dc.subject.keywordAuthor | EGb 761 | - |
dc.subject.keywordAuthor | Gerbil | - |
dc.subject.keywordAuthor | Ischemic reperfusion injury | - |
dc.subject.keywordAuthor | Mitochondrial dysfunction | - |
dc.subject.keywordAuthor | Selegiline | - |
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