Dibenzoylmethane ameliorates lipid-induced inflammation and oxidative injury in diabetic nephropathy
DC Field | Value | Language |
---|---|---|
dc.contributor.author | Lee, Eun Soo | - |
dc.contributor.author | Kwon, Mi-Hye | - |
dc.contributor.author | Kim, Hong Min | - |
dc.contributor.author | Kim, Nami | - |
dc.contributor.author | Kim, You Mi | - |
dc.contributor.author | Kim, Hyeon Soo | - |
dc.contributor.author | Lee, Eun Young | - |
dc.contributor.author | Chung, Choon Hee | - |
dc.date.available | 2020-11-02T06:43:54Z | - |
dc.date.issued | 2019-02 | - |
dc.identifier.issn | 0022-0795 | - |
dc.identifier.issn | 1479-6805 | - |
dc.identifier.uri | https://scholarworks.korea.ac.kr/kumedicine/handle/2020.sw.kumedicine/2399 | - |
dc.description.abstract | Dibenzoylmethane (DBM) is a beta-diketone analog of curcumin. Numerous studies have shown the beneficial effects of curcumin on diabetes, obesity and diabetic complications including diabetic nephropathy. Recently, we investigated the beneficial metabolic effects of DBM on high-fat diet-induced obesity. However, the effects and mechanisms of action of DBM in the kidney are currently unknown. To investigate the renoprotective effects of DBM in type 2 diabetes, we administered DBM (100 mg/kg) orally for 12 weeks to high-fat diet-induced diabetic model mice. We used mouse renal mesangial (MES13) and macrophage (RAW 264.7) cells to examine the mechanism of action of DBM (20 pM). After DBM treatment, the albumin-to-creatinine ratio was significantly decreased compared to that of the high-fat-diet group. Moreover, damaged renal ultra-structures and functions including increased glomerular volume, glomerular basement membrane thickness and inflammatory signals were ameliorated after DBM treatment. Stimulation of MES13 and RAW264.7 cells by palmitate or high-dose glucose with lipopolysaccharides increased inflammatory signals and macrophage migration. However, these changes were reversed by DBM treatment. In addition, DBM inhibited NADPH oxidase 2 and 4 expression and oxidative DNA damage. Collectively, these data suggested that DBM prevented diabetes-induced renal injury through its anti-inflammatory and antioxidant effects. | - |
dc.format.extent | 11 | - |
dc.language | 영어 | - |
dc.language.iso | ENG | - |
dc.publisher | Society for Endocrinology | - |
dc.title | Dibenzoylmethane ameliorates lipid-induced inflammation and oxidative injury in diabetic nephropathy | - |
dc.type | Article | - |
dc.publisher.location | 영국 | - |
dc.identifier.doi | 10.1530/JOE-18-0206 | - |
dc.identifier.scopusid | 2-s2.0-85057105547 | - |
dc.identifier.wosid | 000453043400008 | - |
dc.identifier.bibliographicCitation | Journal of Endocrinology, v.240, no.2, pp 169 - 179 | - |
dc.citation.title | Journal of Endocrinology | - |
dc.citation.volume | 240 | - |
dc.citation.number | 2 | - |
dc.citation.startPage | 169 | - |
dc.citation.endPage | 179 | - |
dc.type.docType | Article | - |
dc.description.isOpenAccess | Y | - |
dc.description.journalRegisteredClass | sci | - |
dc.description.journalRegisteredClass | scie | - |
dc.description.journalRegisteredClass | scopus | - |
dc.relation.journalResearchArea | Endocrinology & Metabolism | - |
dc.relation.journalWebOfScienceCategory | Endocrinology & Metabolism | - |
dc.subject.keywordPlus | ACTIVATED PROTEIN-KINASE | - |
dc.subject.keywordPlus | RENAL INJURY | - |
dc.subject.keywordPlus | INSULIN-RESISTANCE | - |
dc.subject.keywordPlus | PROSTATE-CANCER | - |
dc.subject.keywordPlus | RAT MODEL | - |
dc.subject.keywordPlus | CURCUMIN | - |
dc.subject.keywordPlus | STRESS | - |
dc.subject.keywordPlus | KIDNEY | - |
dc.subject.keywordPlus | OBESITY | - |
dc.subject.keywordPlus | MACROPHAGES | - |
dc.subject.keywordAuthor | diabetic nephropathy | - |
dc.subject.keywordAuthor | dibenzoylmethane | - |
dc.subject.keywordAuthor | lipotoxicity | - |
dc.subject.keywordAuthor | inflammation | - |
dc.subject.keywordAuthor | oxidative stress | - |
Items in ScholarWorks are protected by copyright, with all rights reserved, unless otherwise indicated.
73, Goryeodae-ro, Seongbuk-gu, Seoul, Republic of Korea (02841)82-2-2286-1265
COPYRIGHT 2020 KOREA UNIVERSITY MEDICAL LIBRARY ALL RIGHTS RESERVED.
Certain data included herein are derived from the © Web of Science of Clarivate Analytics. All rights reserved.
You may not copy or re-distribute this material in whole or in part without the prior written consent of Clarivate Analytics.