The effects of neutrophil depletion on a completely noninvasive model of acute pancreatitis-associated lung injury
DC Field | Value | Language |
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dc.contributor.author | Bhatia M. | - |
dc.contributor.author | Saluja A.K. | - |
dc.contributor.author | Hofbauer B. | - |
dc.contributor.author | Lee H.-S. | - |
dc.contributor.author | Frossard J.-L. | - |
dc.contributor.author | Steer M.L. | - |
dc.date.available | 2020-11-04T02:46:42Z | - |
dc.date.issued | 1998 | - |
dc.identifier.issn | 0169-4197 | - |
dc.identifier.uri | https://scholarworks.korea.ac.kr/kumedicine/handle/2020.sw.kumedicine/25023 | - |
dc.description.abstract | Conclusion. A completely noninvasive animal model of acute pancreatitis- associated lung injury was used to show that neutrophils, activated by pancreatitis, play a key role in mediating pancreatitis-associated lung injury. Background. Significant pulmonary complications have been known to occur in over 50% of patients with severe acute pancreatitis. Recent studies using a variety of animal models of pancreatitis have suggested that neutrophil activation may play an important role in mediating lung injury. However, in these models, the interpretation of the results is complicated because surgical manipulations alone could have resulted in the activation of neutrophils. Methods. Young female mice were fed a choline deficient ethionine (CDE) supplemented diet. The severity of pancreatitis was evaluated by measuring hyperamylasemia, acinar cell necrosis, and pancreatic myeloperoxidase activity. Lung injury was quantified by measuring lung microvascular permeability and lung myeloperoxidase activity. To evaluate the role of neutrophils in CDE diet-induced pancreatitis-associated lung injury, animals were pretreated with antineutrophil serum. Results. Mice fed the CDE diet develop pancreatitis-associated lung injury. Pretreatment of mice with antineutrophil serum results in marked depletion of circulating neutrophils. Under these conditions, the severity of pancreatitis is reduced and lung injury is completely prevented. | - |
dc.format.extent | 7 | - |
dc.language | 영어 | - |
dc.language.iso | ENG | - |
dc.title | The effects of neutrophil depletion on a completely noninvasive model of acute pancreatitis-associated lung injury | - |
dc.type | Article | - |
dc.publisher.location | 미국 | - |
dc.identifier.scopusid | 2-s2.0-0031771392 | - |
dc.identifier.bibliographicCitation | International Journal of Pancreatology, v.24, no.2, pp 77 - 83 | - |
dc.citation.title | International Journal of Pancreatology | - |
dc.citation.volume | 24 | - |
dc.citation.number | 2 | - |
dc.citation.startPage | 77 | - |
dc.citation.endPage | 83 | - |
dc.type.docType | Article | - |
dc.description.isOpenAccess | N | - |
dc.description.journalRegisteredClass | scopus | - |
dc.subject.keywordPlus | choline | - |
dc.subject.keywordPlus | ethionine | - |
dc.subject.keywordPlus | granulocyte antibody | - |
dc.subject.keywordPlus | myeloperoxidase | - |
dc.subject.keywordPlus | acinar cell | - |
dc.subject.keywordPlus | acute pancreatitis | - |
dc.subject.keywordPlus | animal experiment | - |
dc.subject.keywordPlus | animal model | - |
dc.subject.keywordPlus | animal tissue | - |
dc.subject.keywordPlus | article | - |
dc.subject.keywordPlus | blood vessel permeability | - |
dc.subject.keywordPlus | cell death | - |
dc.subject.keywordPlus | controlled study | - |
dc.subject.keywordPlus | diet supplementation | - |
dc.subject.keywordPlus | female | - |
dc.subject.keywordPlus | hyperamylasemia | - |
dc.subject.keywordPlus | leukocyte activation | - |
dc.subject.keywordPlus | lung blood vessel | - |
dc.subject.keywordPlus | lung injury | - |
dc.subject.keywordPlus | mouse | - |
dc.subject.keywordPlus | neutropenia | - |
dc.subject.keywordPlus | nonhuman | - |
dc.subject.keywordPlus | priority journal | - |
dc.subject.keywordPlus | vitamin deficiency | - |
dc.subject.keywordPlus | Acute Disease | - |
dc.subject.keywordPlus | Animals | - |
dc.subject.keywordPlus | Choline | - |
dc.subject.keywordPlus | Diet | - |
dc.subject.keywordPlus | Ethionine | - |
dc.subject.keywordPlus | Female | - |
dc.subject.keywordPlus | Immunization, Passive | - |
dc.subject.keywordPlus | Leukocyte Count | - |
dc.subject.keywordPlus | Lung Diseases | - |
dc.subject.keywordPlus | Mice | - |
dc.subject.keywordPlus | Mice, Inbred Strains | - |
dc.subject.keywordPlus | Neutrophils | - |
dc.subject.keywordPlus | Pancreatitis | - |
dc.subject.keywordPlus | Peroxidase | - |
dc.subject.keywordAuthor | Acute pancreatitis | - |
dc.subject.keywordAuthor | CDE diet | - |
dc.subject.keywordAuthor | Lung injury | - |
dc.subject.keywordAuthor | Myeloperoxidase | - |
dc.subject.keywordAuthor | Neutrophil sequestration | - |
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