Detailed Information

Cited 19 time in webofscience Cited 18 time in scopus
Metadata Downloads

Assessment and prediction of acute kidney injury in patients with decompensated cirrhosis with serum cystatin C and urine N-acetyl-beta-D-glucosaminidase

Full metadata record
DC Field Value Language
dc.contributor.authorKim, Tae Hyung-
dc.contributor.authorLee, Han Ah-
dc.contributor.authorSeo, Yeon Seok-
dc.contributor.authorLee, Yoo Ra-
dc.contributor.authorYim, Sun Young-
dc.contributor.authorLee, Young Sun-
dc.contributor.authorSuh, Sang Jun-
dc.contributor.authorJung, Young Kul-
dc.contributor.authorKim, Ji Hoon-
dc.contributor.authorAn, Hyunggin-
dc.contributor.authorYim, Hyung Joon-
dc.contributor.authorYeon, Jong Eun-
dc.contributor.authorByun, Kwan Soo-
dc.contributor.authorUm, Soon Ho-
dc.contributor.authorKorean Study Group of Portal Hypertension-
dc.date.available2020-11-02T06:44:33Z-
dc.date.issued2019-01-
dc.identifier.issn0815-9319-
dc.identifier.issn1440-1746-
dc.identifier.urihttps://scholarworks.korea.ac.kr/kumedicine/handle/2020.sw.kumedicine/2539-
dc.description.abstractBackground and Aim For appropriate management of acute kidney injury (AKI) in cirrhotic patients, accurate differentiation of the types of AKI, prerenal azotemia (PRA), hepatorenal syndrome (HRS), and acute tubular necrosis (ATN) is very important. Urine N-acetyl-β-D-glucosaminidase (NAG) has been proposed as a good tubular injury marker in many studies, but its efficacy in cirrhosis is unclear. This study was performed to evaluate the usefulness of urine NAG in patients with decompensated cirrhosis. Methods In 114 hospitalized patients with decompensated cirrhosis, we assessed serum creatinine, cystatin C, and urine NAG levels as markers for AKI differentiation and development and patient mortality. Results Thirty patients diagnosed with AKI at baseline had significantly higher serum creatinine and cystatin C levels, urine NAG levels, and Child–Pugh scores than those without AKI. Only urine NAG levels were significantly higher in patients with ATN than those with PRA or HRS (116.1 ± 46.8 U/g vs 39.4 ± 20.2 or 54.0 ± 19.2 U/g urinary creatinine, all P < 0.05). During a median follow up of 6.1 months, AKI developed in 17 of 84 patients: PRA in nine, HRS in six, and ATN in three. Higher serum cystatin C and urine NAG levels were independent predictors of AKI development in patients with decompensated cirrhosis. Survival was significantly associated with low serum cystatin C and urine NAG levels. Conclusion Serum cystatin C and urine NAG levels are useful to differentiate types of AKI and are strong predictors for AKI development and mortality in patients with decompensated cirrhosis.-
dc.format.extent7-
dc.language영어-
dc.language.isoENG-
dc.publisherBlackwell Publishing Inc.-
dc.titleAssessment and prediction of acute kidney injury in patients with decompensated cirrhosis with serum cystatin C and urine N-acetyl-beta-D-glucosaminidase-
dc.typeArticle-
dc.publisher.location미국-
dc.identifier.doi10.1111/jgh.14387-
dc.identifier.scopusid2-s2.0-85053220601-
dc.identifier.wosid000455896500034-
dc.identifier.bibliographicCitationJournal of Gastroenterology and Hepatology, v.34, no.1, pp 234 - 240-
dc.citation.titleJournal of Gastroenterology and Hepatology-
dc.citation.volume34-
dc.citation.number1-
dc.citation.startPage234-
dc.citation.endPage240-
dc.type.docTypeArticle-
dc.description.isOpenAccessN-
dc.description.journalRegisteredClasssci-
dc.description.journalRegisteredClassscie-
dc.description.journalRegisteredClassscopus-
dc.relation.journalResearchAreaGastroenterology & Hepatology-
dc.relation.journalWebOfScienceCategoryGastroenterology & Hepatology-
dc.subject.keywordPlusGELATINASE-ASSOCIATED LIPOCALIN-
dc.subject.keywordPlusCHRONIC LIVER-FAILURE-
dc.subject.keywordPlusRENAL-FUNCTION-
dc.subject.keywordPlusDIFFERENTIAL-DIAGNOSIS-
dc.subject.keywordPlusBIOMARKERS-
dc.subject.keywordPlusMORTALITY-
dc.subject.keywordPlusMARKER-
dc.subject.keywordPlusASCITES-
dc.subject.keywordPlusNEPHROTOXICITY-
dc.subject.keywordPlusCOMPLICATIONS-
dc.subject.keywordAuthoracute kidney injury-
dc.subject.keywordAuthoracute tubular necrosis-
dc.subject.keywordAuthorcystatin C-
dc.subject.keywordAuthorhepatorenal syndrome-
dc.subject.keywordAuthorliver cirrhosis-
dc.subject.keywordAuthorN-acetyl-beta-D-glucosaminidase-
Files in This Item
There are no files associated with this item.
Appears in
Collections
1. Basic Science > Department of Biostatistics > 1. Journal Articles
2. Clinical Science > Department of Gastroenterology and Hepatology > 1. Journal Articles

qrcode

Items in ScholarWorks are protected by copyright, with all rights reserved, unless otherwise indicated.

Related Researcher

Researcher Lee, Young Sun photo

Lee, Young Sun
Guro Hospital (Department of Gastroenterology and Hepatology, Guro Hospital)
Read more

Altmetrics

Total Views & Downloads

BROWSE