The role of senescence of bone marrow cells in acute kidney injury
DC Field | Value | Language |
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dc.contributor.author | Lee J. | - |
dc.contributor.author | Ko Y.S. | - |
dc.contributor.author | Lee H.Y. | - |
dc.contributor.author | Yang J. | - |
dc.contributor.author | Oh S. | - |
dc.contributor.author | Jo S.-K. | - |
dc.contributor.author | Cho W. | - |
dc.contributor.author | Kim M.-G. | - |
dc.date.available | 2020-11-02T06:50:03Z | - |
dc.date.issued | 2019-03 | - |
dc.identifier.issn | 2211-9132 | - |
dc.identifier.issn | 2211-9140 | - |
dc.identifier.uri | https://scholarworks.korea.ac.kr/kumedicine/handle/2020.sw.kumedicine/2748 | - |
dc.description.abstract | Background: The prevalence of acute kidney injury (AKI) in elderly patients has grown considerably. Age-associated changes in the immune system can be one of the critical factors determining AKI outcomes. This study aimed to investigate the role of senescence of bone marrow (BM)-derived cells in the development of AKI, focusing on the immune response. Methods: Female 7-week-old C57BL/6 mice were irradiated and treated with BM cells from either 48-week-old or 8-week-old male mice. Ischemia-reperfusion injury (IRI) was induced, and their functional deterioration, histological tubular damage, and inflammatory responses were compared. For the in vitro study, lipopolysaccharide (LPS)-stimulated cytokine production by BM cells from old and young mice were examined. Results: At 24 hours after IRI, there was no significant difference in the number of circulating immune cells between the mice transplanted with old or young BM cells. However, the mice with old BM cells showed less functional deterioration and histological tubular injury than those with young BM cells. Moreover, macrophage infiltration and renal cytokine interleukin (IL)-12 levels were lower in the mice with old BM cells at 24 hours post-IRI. Consistently, the in vitro study showed that LPS-induced production of cytokines interferon-γ, monocyte chemoattractant protein-1, and IL-10 was attenuated in cultured old BM cells, suggesting that age-related functional changes in these cells may lead to reduced inflammation in IRI. Conclusion: Immunosenescence could affect the susceptibility and response to renal IRI. Further studies specifically addressing age-related alterations can help in the development of treatment strategies for elderly patients with AKI. © 2019 by The Korean Society of Nephrology. | - |
dc.format.extent | 8 | - |
dc.language | 영어 | - |
dc.language.iso | ENG | - |
dc.publisher | The Korean Society of Nephrology | - |
dc.title | The role of senescence of bone marrow cells in acute kidney injury | - |
dc.type | Article | - |
dc.publisher.location | 대한민국 | - |
dc.identifier.doi | 10.23876/j.krcp.18.0114 | - |
dc.identifier.scopusid | 2-s2.0-85067259800 | - |
dc.identifier.wosid | 000462002500005 | - |
dc.identifier.bibliographicCitation | Kidney Research and Clinical Practice, v.38, no.1, pp 25 - 32 | - |
dc.citation.title | Kidney Research and Clinical Practice | - |
dc.citation.volume | 38 | - |
dc.citation.number | 1 | - |
dc.citation.startPage | 25 | - |
dc.citation.endPage | 32 | - |
dc.type.docType | Article | - |
dc.identifier.kciid | ART002447924 | - |
dc.description.isOpenAccess | N | - |
dc.description.journalRegisteredClass | scopus | - |
dc.description.journalRegisteredClass | esci | - |
dc.description.journalRegisteredClass | kci | - |
dc.relation.journalResearchArea | Urology & Nephrology | - |
dc.relation.journalWebOfScienceCategory | Urology & Nephrology | - |
dc.subject.keywordPlus | arginase 1 | - |
dc.subject.keywordPlus | CD4 antigen | - |
dc.subject.keywordPlus | creatinine | - |
dc.subject.keywordPlus | f4 80 protein | - |
dc.subject.keywordPlus | gamma interferon | - |
dc.subject.keywordPlus | gamma interferon antibody | - |
dc.subject.keywordPlus | inducible nitric oxide synthase | - |
dc.subject.keywordPlus | interleukin 10 | - |
dc.subject.keywordPlus | interleukin 12 | - |
dc.subject.keywordPlus | interleukin 12p70 | - |
dc.subject.keywordPlus | interleukin 6 | - |
dc.subject.keywordPlus | monocyte chemotactic protein 1 | - |
dc.subject.keywordPlus | peptides and proteins | - |
dc.subject.keywordPlus | transforming growth factor beta | - |
dc.subject.keywordPlus | transforming growth factor beta1 | - |
dc.subject.keywordPlus | tumor necrosis factor | - |
dc.subject.keywordPlus | unclassified drug | - |
dc.subject.keywordPlus | acute kidney failure | - |
dc.subject.keywordPlus | animal experiment | - |
dc.subject.keywordPlus | animal model | - |
dc.subject.keywordPlus | animal tissue | - |
dc.subject.keywordPlus | Article | - |
dc.subject.keywordPlus | bone marrow cell | - |
dc.subject.keywordPlus | bone marrow transplantation | - |
dc.subject.keywordPlus | cell aging | - |
dc.subject.keywordPlus | cell infiltration | - |
dc.subject.keywordPlus | controlled study | - |
dc.subject.keywordPlus | cytokine production | - |
dc.subject.keywordPlus | disease course | - |
dc.subject.keywordPlus | female | - |
dc.subject.keywordPlus | flow cytometry | - |
dc.subject.keywordPlus | gene expression | - |
dc.subject.keywordPlus | histopathology | - |
dc.subject.keywordPlus | immune reconstitution | - |
dc.subject.keywordPlus | immune response | - |
dc.subject.keywordPlus | immunohistochemistry | - |
dc.subject.keywordPlus | kidney injury | - |
dc.subject.keywordPlus | macrophage | - |
dc.subject.keywordPlus | male | - |
dc.subject.keywordPlus | mouse | - |
dc.subject.keywordPlus | nephritis | - |
dc.subject.keywordPlus | nonhuman | - |
dc.subject.keywordPlus | priority journal | - |
dc.subject.keywordPlus | protein expression | - |
dc.subject.keywordPlus | protein expression level | - |
dc.subject.keywordPlus | real time polymerase chain reaction | - |
dc.subject.keywordPlus | reperfusion injury | - |
dc.subject.keywordAuthor | Acute kidney injury | - |
dc.subject.keywordAuthor | Aging | - |
dc.subject.keywordAuthor | Immunosenescence | - |
dc.subject.keywordAuthor | Ischemia reperfusion injury | - |
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