The Effects of Hyperuricemia on the Prognosis of IgA Nephropathy are More Potent in Females
DC Field | Value | Language |
---|---|---|
dc.contributor.author | Oh, Tae Ryom | - |
dc.contributor.author | Choi, Hong Sang | - |
dc.contributor.author | Kim, Chang Seong | - |
dc.contributor.author | Kang, Kyung Pyo | - |
dc.contributor.author | Kwon, Young Joo | - |
dc.contributor.author | Kim, Sung Gyun | - |
dc.contributor.author | Ma, Seong Kwon | - |
dc.contributor.author | Kim, Soo Wan | - |
dc.contributor.author | Bae, Eun Hui | - |
dc.date.available | 2020-11-10T06:51:57Z | - |
dc.date.issued | 2020-01 | - |
dc.identifier.issn | 2077-0383 | - |
dc.identifier.issn | 2077-0383 | - |
dc.identifier.uri | https://scholarworks.korea.ac.kr/kumedicine/handle/2020.sw.kumedicine/28300 | - |
dc.description.abstract | Hyperuricemia is a potential risk factor for immunoglobulin A nephropathy (IgAN) progression but its sex-specific effects on IgAN progression remain unclear. This study aimed to determine the effect of serum uric acid on IgAN progression and whether its effect varied according to sex. A total of 4339 patients who diagnosed with IgAN by renal biopsy were retrospectively analyzed. We assessed the association of serum uric acid on IgAN progression using Kaplan-Meier survival analyses and Cox proportional hazards models. The study's primary end point was IgAN progression that was defined as a 50% decline in the estimated glomerular filtration rate or the initiation of dialysis. On average, the serum uric acid levels were higher in the men than in the women. In the fully adjusted Cox proportional hazards model that considered all subjects, the risk of IgAN progression increased by about 25.6% for every 1 mg/dL increase in the baseline uric acid level. The serum uric acid level was an independent risk factor for IgAN progression in both sexes but its effect was more pronounced in the women (hazard ratio [HR], 1.383; confidence interval [CI],1.263 to 1.514; p < 0.001) than in the men (HR, 1.181; CI, 1.097 to 1.272; p < 0.001) (p(interaction) < 0.001). A sensitivity analysis involving serum uric acid quartiles generated consistent and robust results. In conclusion, the serum uric acid level was an independent risk factor for IgAN progression and its effect was more pronounced among the women compared with that among the men. | - |
dc.language | 영어 | - |
dc.language.iso | ENG | - |
dc.publisher | MDPI | - |
dc.title | The Effects of Hyperuricemia on the Prognosis of IgA Nephropathy are More Potent in Females | - |
dc.type | Article | - |
dc.publisher.location | 스위스 | - |
dc.identifier.doi | 10.3390/jcm9010176 | - |
dc.identifier.scopusid | 2-s2.0-85100685731 | - |
dc.identifier.wosid | 000515388400176 | - |
dc.identifier.bibliographicCitation | Journal of Clinical Medicine, v.9, no.1 | - |
dc.citation.title | Journal of Clinical Medicine | - |
dc.citation.volume | 9 | - |
dc.citation.number | 1 | - |
dc.type.docType | Article | - |
dc.description.isOpenAccess | Y | - |
dc.description.journalRegisteredClass | scie | - |
dc.description.journalRegisteredClass | scopus | - |
dc.relation.journalResearchArea | General & Internal Medicine | - |
dc.relation.journalWebOfScienceCategory | Medicine, General & Internal | - |
dc.subject.keywordPlus | SERUM URIC-ACID | - |
dc.subject.keywordPlus | GLOMERULAR-FILTRATION-RATE | - |
dc.subject.keywordPlus | CHRONIC KIDNEY-DISEASE | - |
dc.subject.keywordPlus | URATE TRANSPORTER | - |
dc.subject.keywordPlus | ASSOCIATION | - |
dc.subject.keywordPlus | SEX | - |
dc.subject.keywordPlus | SLC2A9 | - |
dc.subject.keywordPlus | RISK | - |
dc.subject.keywordPlus | PROGRESSION | - |
dc.subject.keywordPlus | PREDICTOR | - |
dc.subject.keywordAuthor | Ig A nephropathy | - |
dc.subject.keywordAuthor | hyperuricemia | - |
dc.subject.keywordAuthor | uric acid | - |
dc.subject.keywordAuthor | glomerulonephritis | - |
dc.subject.keywordAuthor | renal outcome | - |
dc.subject.keywordAuthor | female | - |
dc.subject.keywordAuthor | disease progression | - |
dc.subject.keywordAuthor | prognosis | - |
dc.subject.keywordAuthor | risk factor | - |
dc.subject.keywordAuthor | sex | - |
Items in ScholarWorks are protected by copyright, with all rights reserved, unless otherwise indicated.
73, Goryeodae-ro, Seongbuk-gu, Seoul, Republic of Korea (02841)82-2-2286-1265
COPYRIGHT 2020 KOREA UNIVERSITY MEDICAL LIBRARY ALL RIGHTS RESERVED.
Certain data included herein are derived from the © Web of Science of Clarivate Analytics. All rights reserved.
You may not copy or re-distribute this material in whole or in part without the prior written consent of Clarivate Analytics.