‘Minimal symptom expression’ in patients with acetylcholine receptor antibody-positive refractory generalized myasthenia gravis treated with eculizumab
DC Field | Value | Language |
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dc.contributor.author | Vissing, John | - |
dc.contributor.author | Jacob, Saiju | - |
dc.contributor.author | Fujita, Kenji P. | - |
dc.contributor.author | O’Brien, Fanny | - |
dc.contributor.author | Howard, James F. | - |
dc.contributor.author | Mazia, C.G. | - |
dc.contributor.author | Wilken, M. | - |
dc.contributor.author | Barroso, F. | - |
dc.contributor.author | Saba, J. | - |
dc.contributor.author | Rugiero, M. | - |
dc.contributor.author | Bettini, M. | - |
dc.contributor.author | Chaves, M. | - |
dc.contributor.author | Vidal, G. | - |
dc.contributor.author | Garcia, A.D. | - |
dc.contributor.author | De Bleecker, J. | - |
dc.contributor.author | Van den, Abeele G. | - |
dc.contributor.author | de Koning, K. | - |
dc.contributor.author | De Mey, K. | - |
dc.contributor.author | Mercelis, R. | - |
dc.contributor.author | Mahieu, D. | - |
dc.contributor.author | Wagemaekers, L. | - |
dc.contributor.author | Van Damme, P. | - |
dc.contributor.author | Depreitere, A. | - |
dc.contributor.author | Schotte, C. | - |
dc.contributor.author | Smetcoren, C. | - |
dc.contributor.author | Stevens, O. | - |
dc.contributor.author | Van Daele, S. | - |
dc.contributor.author | Vandenbussche, N. | - |
dc.contributor.author | Vanhee, A. | - |
dc.contributor.author | Verjans, S. | - |
dc.contributor.author | Vynckier, J. | - |
dc.contributor.author | D’Hont, A. | - |
dc.contributor.author | Tilkin, P. | - |
dc.contributor.author | Alves, de Siqueira Carvalho A. | - |
dc.contributor.author | Dias Brockhausen, I. | - |
dc.contributor.author | Feder, D. | - |
dc.contributor.author | Ambrosio, D. | - |
dc.contributor.author | César, P. | - |
dc.contributor.author | Melo, A.P. | - |
dc.contributor.author | Martins Ribeiro, R. | - |
dc.contributor.author | Rocha, R. | - |
dc.contributor.author | Rosa, B.B. | - |
dc.contributor.author | Veiga, T. | - |
dc.contributor.author | da Silva, L.A. | - |
dc.contributor.author | Santos Engel, M. | - |
dc.contributor.author | Gonçalves Geraldo, J. | - |
dc.contributor.author | da Penha, Ananias Morita M. | - |
dc.contributor.author | Nogueira Coelho, E. | - |
dc.contributor.author | Paiva, G. | - |
dc.contributor.author | Pozo, M. | - |
dc.contributor.author | Prando, N. | - |
dc.contributor.author | Martineli Torres, D.D. | - |
dc.contributor.author | Butinhao, C.F. | - |
dc.contributor.author | Duran, G. | - |
dc.contributor.author | Suriane Fialho, T.A. | - |
dc.contributor.author | Gomes, da Silva T.C. | - |
dc.contributor.author | Maia Gonçalves, L.O. | - |
dc.contributor.author | Pazetto, L.E. | - |
dc.contributor.author | Cubas Volpe, L.R. | - |
dc.contributor.author | Souza Duca, L. | - |
dc.contributor.author | Gheller Friedrich, M.A. | - |
dc.contributor.author | Guerreiro, A. | - |
dc.contributor.author | Mohr, H. | - |
dc.contributor.author | Pereira Martins, M. | - |
dc.contributor.author | da Cruz, Pacheco D. | - |
dc.contributor.author | Ferreira, L. | - |
dc.contributor.author | Macagnan, A.P. | - |
dc.contributor.author | Pinto, G. | - |
dc.contributor.author | de Cassia, Santos A. | - |
dc.contributor.author | Souza, Bulle Oliveira A. | - |
dc.contributor.author | Amaral, de Andrade A.C. | - |
dc.contributor.author | Annes, M. | - |
dc.contributor.author | Duarte Silva, L. | - |
dc.contributor.author | Cavalcante Lino, V. | - |
dc.contributor.author | Pinto, W. | - |
dc.contributor.author | Assis, N. | - |
dc.contributor.author | Carrara, F. | - |
dc.contributor.author | Miranda, C. | - |
dc.contributor.author | Souza, I. | - |
dc.contributor.author | Fernandes, P. | - |
dc.contributor.author | Siddiqi, Z. | - |
dc.contributor.author | Phan, C. | - |
dc.contributor.author | Narayan, J. | - |
dc.contributor.author | Blackmore, D. | - |
dc.contributor.author | Mallon, A. | - |
dc.contributor.author | Roderus, R. | - |
dc.contributor.author | Watt, E. | - |
dc.contributor.author | Vohanka, S. | - |
dc.contributor.author | Bednarik, J. | - |
dc.contributor.author | Chmelikova, M. | - |
dc.contributor.author | Cierny, M. | - |
dc.contributor.author | Toncrova, S. | - |
dc.contributor.author | Junkerova, Barbora Kurkova J. | - |
dc.contributor.author | Reguliova, K. | - |
dc.contributor.author | Zapletalova, O. | - |
dc.contributor.author | Pitha, J. | - |
dc.contributor.author | Novakova, I. | - |
dc.contributor.author | Tyblova, M. | - |
dc.contributor.author | Jurajdova, I. | - |
dc.contributor.author | Wolfova, M. | - |
dc.contributor.author | Andersen, H. | - |
dc.contributor.author | Harbo, T. | - |
dc.contributor.author | Vinge, L. | - |
dc.contributor.author | Krogh, S. | - |
dc.contributor.author | Mogensen, A. | - |
dc.contributor.author | Vissing, J. | - |
dc.contributor.author | Højgaard, J. | - |
dc.contributor.author | Witting, N. | - |
dc.contributor.author | Mette, Ostergaard Autzen A. | - |
dc.contributor.author | Pedersen, J. | - |
dc.contributor.author | Erälinna, J.-P. | - |
dc.contributor.author | Laaksonen, M. | - |
dc.contributor.author | Oksaranta, O. | - |
dc.contributor.author | Harrison, T. | - |
dc.contributor.author | Eriksson, J. | - |
dc.contributor.author | Rozsa, C. | - |
dc.contributor.author | Horvath, M. | - |
dc.contributor.author | Lovas, G. | - |
dc.contributor.author | Matolcsi, J. | - |
dc.contributor.author | Szabo, G. | - |
dc.contributor.author | Jakab, G. | - |
dc.contributor.author | Szabadosne, B. | - |
dc.contributor.author | Vecsei, L. | - |
dc.contributor.author | Dezsi, L. | - |
dc.contributor.author | Varga, E. | - |
dc.contributor.author | Konyane, M. | - |
dc.contributor.author | Antonini, G. | - |
dc.contributor.author | Di Pasquale, A. | - |
dc.contributor.author | Garibaldi, M. | - |
dc.contributor.author | Morino, S. | - |
dc.contributor.author | Troili, F. | - |
dc.contributor.author | Fionda, L. | - |
dc.contributor.author | Saccà, F. | - |
dc.contributor.author | previous, | - |
dc.contributor.author | Filla, A. | - |
dc.contributor.author | sub-investigators, | - |
dc.contributor.author | Costabile, T. | - |
dc.contributor.author | Marano, E. | - |
dc.contributor.author | Fasanaro, A. | - |
dc.contributor.author | Marsili, A. | - |
dc.contributor.author | Puorro, G. | - |
dc.contributor.author | Mantegazza, R. | - |
dc.contributor.author | Antozzi, C. | - |
dc.contributor.author | Bonanno, S. | - |
dc.contributor.author | Camera, G. | - |
dc.contributor.author | Locatelli, A. | - |
dc.contributor.author | Maggi, L. | - |
dc.contributor.author | Pasanisi, M. | - |
dc.contributor.author | Campanella, A. | - |
dc.contributor.author | Evoli, A. | - |
dc.contributor.author | Alboini, P.E. | - |
dc.contributor.author | D’Amato, V. | - |
dc.contributor.author | Iorio, R. | - |
dc.contributor.author | Inghilleri, M. | - |
dc.contributor.author | Fionda, L. | - |
dc.contributor.author | Frasca, V. | - |
dc.contributor.author | Giacomelli, E. | - |
dc.contributor.author | Gori, M. | - |
dc.contributor.author | Lopergolo, D. | - |
dc.contributor.author | Onesti, E. | - |
dc.contributor.author | Frasca, V. | - |
dc.contributor.author | Gabriele, M. | - |
dc.contributor.author | Uzawa, A. | - |
dc.contributor.author | Kanai, T. | - |
dc.contributor.author | Kawaguchi, N. | - |
dc.contributor.author | Mori, M. | - |
dc.contributor.author | Kaneko, Y. | - |
dc.contributor.author | Kanzaki, A. | - |
dc.contributor.author | Kobayashi, E. | - |
dc.contributor.author | Murai, H. | - |
dc.contributor.author | Masaki, K. | - |
dc.contributor.author | Matsuse, D. | - |
dc.contributor.author | Matsushita, T. | - |
dc.contributor.author | Uehara, T. | - |
dc.contributor.author | Shimpo, M. | - |
dc.contributor.author | Jingu, M. | - |
dc.contributor.author | Kikutake, K. | - |
dc.contributor.author | Nakamura, Y. | - |
dc.contributor.author | Sano, Y. | - |
dc.contributor.author | Utsugisawa, K. | - |
dc.contributor.author | Nagane, Y. | - |
dc.contributor.author | Kamegamori, I. | - |
dc.contributor.author | Tsuda, T. | - |
dc.contributor.author | Fujii, Y. | - |
dc.contributor.author | Futono, K. | - |
dc.contributor.author | Ozawa, Y. | - |
dc.contributor.author | Mizugami, A. | - |
dc.contributor.author | Saito, Y. | - |
dc.contributor.author | Samukawa, M. | - |
dc.contributor.author | Suzuki, H. | - |
dc.contributor.author | Morikawa, M. | - |
dc.contributor.author | Kamakura, S. | - |
dc.contributor.author | Miyawaki, E. | - |
dc.contributor.author | Shiraishi, H. | - |
dc.contributor.author | Mitazaki, T. | - |
dc.contributor.author | Motomura, M. | - |
dc.contributor.author | Mukaino, A. | - |
dc.contributor.author | Yoshimura, S. | - |
dc.contributor.author | Asada, S. | - |
dc.contributor.author | Yoshida, S. | - |
dc.contributor.author | Amamoto, S. | - |
dc.contributor.author | Kobashikawa, T. | - |
dc.contributor.author | Koga, M. | - |
dc.contributor.author | Maeda, Y. | - |
dc.contributor.author | Takada, K. | - |
dc.contributor.author | Takada, M. | - |
dc.contributor.author | Tsurumaru, M. | - |
dc.contributor.author | Yamashita, Y. | - |
dc.contributor.author | Yoshida, S. | - |
dc.contributor.author | Suzuki, Y. | - |
dc.contributor.author | Akiyama, T. | - |
dc.contributor.author | Narikawa, K. | - |
dc.contributor.author | Tano, O. | - |
dc.contributor.author | Tsukita, K. | - |
dc.contributor.author | Kurihara, R. | - |
dc.contributor.author | Meguro, F. | - |
dc.contributor.author | Fukuda, Y. | - |
dc.contributor.author | Sato, M. | - |
dc.contributor.author | Okumura, M. | - |
dc.contributor.author | Funaka, S. | - |
dc.contributor.author | Kawamura, T. | - |
dc.contributor.author | Makamori, M. | - |
dc.contributor.author | Takahashi, M. | - |
dc.contributor.author | Taichi, N. | - |
dc.contributor.author | Hasuike, T. | - |
dc.contributor.author | Higuchi, E. | - |
dc.contributor.author | Kobayashi, H. | - |
dc.contributor.author | Osakada, K. | - |
dc.contributor.author | Imai, T. | - |
dc.contributor.author | Tsuda, E. | - |
dc.contributor.author | previous, | - |
dc.contributor.author | Shimohama, S. | - |
dc.contributor.author | Hayashi, T. | - |
dc.contributor.author | Hisahara, S. | - |
dc.contributor.author | Imai, T. | - |
dc.contributor.author | Kawamata, J. | - |
dc.contributor.author | Murahara, T. | - |
dc.contributor.author | Saitoh, M. | - |
dc.contributor.author | Shimohama, S. | - |
dc.contributor.author | Suzuki, S. | - |
dc.contributor.author | Yamamoto, D. | - |
dc.contributor.author | Ishiyama, Y. | - |
dc.contributor.author | Ishiyama, N. | - |
dc.contributor.author | Noshiro, M. | - |
dc.contributor.author | Takeyama, R. | - |
dc.contributor.author | Uwasa, K. | - |
dc.contributor.author | Yasuda, I. | - |
dc.contributor.author | Kim, Byung-Jo | - |
dc.contributor.author | Lee, C.N. | - |
dc.contributor.author | Koo, Y.S. | - |
dc.contributor.author | Seok, H.Y. | - |
dc.contributor.author | Kang, H.N. | - |
dc.contributor.author | Ra, H.J. | - |
dc.contributor.author | Kim, B.J. | - |
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dc.contributor.author | Lee, H.L. | - |
dc.contributor.author | Min, J.-H. | - |
dc.contributor.author | Seok, J. | - |
dc.contributor.author | Lee, J.E. | - |
dc.contributor.author | Koh, D.Y. | - |
dc.contributor.author | Kwon, J.Y. | - |
dc.contributor.author | Park, S.A. | - |
dc.contributor.author | Choi, E.H. | - |
dc.contributor.author | Hong, Y.-H. | - |
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dc.contributor.author | Kim, S.M. | - |
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dc.contributor.author | Gomez Salcedo, P. | - |
dc.contributor.author | Fernandez-Fournier, M. | - |
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dc.contributor.author | Mathew, V. | - |
dc.contributor.author | Maqsood, F. | - |
dc.contributor.author | Minton, B. | - |
dc.contributor.author | Jones, H.J. | - |
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dc.contributor.author | Garcia, R. | - |
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dc.contributor.author | Aranke, S. | - |
dc.contributor.author | Berger, A.R. | - |
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dc.contributor.author | Varghese, M. | - |
dc.contributor.author | Shabbir, Y. | - |
dc.contributor.author | Gutmann, L. | - |
dc.contributor.author | Gutmann, L. | - |
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dc.contributor.author | Nance, C. | - |
dc.contributor.author | Swenson, A. | - |
dc.contributor.author | Olalde, H. | - |
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dc.contributor.author | Malekniazi, A. | - |
dc.contributor.author | Tandan, R. | - |
dc.contributor.author | Hehir, M. | - |
dc.contributor.author | Waheed, W. | - |
dc.contributor.author | Lucy, S. | - |
dc.contributor.author | Weiss, M. | - |
dc.contributor.author | Distad, J. | - |
dc.contributor.author | Strom, S. | - |
dc.contributor.author | Downing, S. | - |
dc.contributor.author | Kim, B. | - |
dc.contributor.author | Bertorini, T. | - |
dc.contributor.author | Arnold, T. | - |
dc.contributor.author | Henderson, K. | - |
dc.contributor.author | Pillai, R. | - |
dc.contributor.author | Liu, Y. | - |
dc.contributor.author | Wheeler, L. | - |
dc.contributor.author | Hewlett, J. | - |
dc.contributor.author | Vanderhook, M. | - |
dc.contributor.author | Nowak, R. | - |
dc.contributor.author | Dicapua, D. | - |
dc.contributor.author | Keung, B. | - |
dc.contributor.author | Kumar, A. | - |
dc.contributor.author | Patwa, H. | - |
dc.contributor.author | Robeson, K. | - |
dc.contributor.author | Yang, I. | - |
dc.contributor.author | Nye, J. | - |
dc.contributor.author | Vu, H. | - |
dc.contributor.author | The, REGAIN study group | - |
dc.date.available | 2020-11-10T06:52:45Z | - |
dc.date.issued | 2020-07 | - |
dc.identifier.issn | 0340-5354 | - |
dc.identifier.issn | 1432-1459 | - |
dc.identifier.uri | https://scholarworks.korea.ac.kr/kumedicine/handle/2020.sw.kumedicine/28339 | - |
dc.description.abstract | Background The efficacy and tolerability of eculizumab were assessed in REGAIN, a 26-week, phase 3, randomized, double-blind, placebo-controlled study in anti-acetylcholine receptor antibody-positive (AChR+) refractory generalized myasthenia gravis (gMG), and its open-label extension. Methods Attainment of ‘minimal symptom expression’ was evaluated using patient-reported outcome measures of gMG symptoms [MG activities of daily living scale (MG-ADL), 15-item MG quality of life questionnaire (MG-QOL15)] at the completion of REGAIN and during the open-label extension. ‘Minimal symptom expression’ was defined as MG-ADL total score of 0–1 or MG-QOL15 total score of 0–3. Results At REGAIN week 26, more eculizumab-treated patients achieved ‘minimal symptom expression’ versus placebo [MG-ADL: 21.4% vs 1.7%; difference 19.8%; 95% confidence interval (CI) 8.5, 31.0; p = 0.0007; MG-QOL15: 16.1% vs 1.7%; difference 14.4%; 95% CI 4.3, 24.6; p = 0.0069]. During the open-label extension, the proportion of patients in the placebo/eculizumab group who achieved ‘minimal symptom expression’ increased after initiating eculizumab treatment and was sustained through 130 weeks of open-label eculizumab (MG-ADL: 1.7 to 27.8%; MG-QOL15: 1.7 to 19.4%). At extension study week 130, similar proportions of patients in the eculizumab/eculizumab and placebo/eculizumab groups achieved ‘minimal symptom expression’ (MG-ADL: 22.9% and 27.8%, respectively, p = 0.7861; MG-QOL15: 14.3% and 19.4%, respectively, p = 0.7531). The long-term tolerability of eculizumab was consistent with previous reports. Conclusions Patients with AChR+ refractory gMG who receive eculizumab can achieve sustained ‘minimal symptom expression’ based on patient-reported outcomes. ‘Minimal symptom expression’ may be a useful tool in measuring therapy effectiveness in gMG. | - |
dc.format.extent | 11 | - |
dc.language | 영어 | - |
dc.language.iso | ENG | - |
dc.publisher | Dr. Dietrich Steinkopff Verlag | - |
dc.title | ‘Minimal symptom expression’ in patients with acetylcholine receptor antibody-positive refractory generalized myasthenia gravis treated with eculizumab | - |
dc.type | Article | - |
dc.publisher.location | 독일 | - |
dc.identifier.doi | 10.1007/s00415-020-09770-y | - |
dc.identifier.scopusid | 2-s2.0-85085089028 | - |
dc.identifier.wosid | 000549382300001 | - |
dc.identifier.bibliographicCitation | Journal of Neurology, v.267, no.7, pp 1991 - 2001 | - |
dc.citation.title | Journal of Neurology | - |
dc.citation.volume | 267 | - |
dc.citation.number | 7 | - |
dc.citation.startPage | 1991 | - |
dc.citation.endPage | 2001 | - |
dc.type.docType | Article | - |
dc.description.isOpenAccess | N | - |
dc.description.journalRegisteredClass | scie | - |
dc.description.journalRegisteredClass | scopus | - |
dc.relation.journalResearchArea | Neurosciences & Neurology | - |
dc.relation.journalWebOfScienceCategory | Clinical Neurology | - |
dc.subject.keywordPlus | COMPLEMENT INHIBITOR ECULIZUMAB | - |
dc.subject.keywordPlus | CYCLOPHOSPHAMIDE | - |
dc.subject.keywordAuthor | Eculizumab | - |
dc.subject.keywordAuthor | Refractory | - |
dc.subject.keywordAuthor | Myasthenia gravis | - |
dc.subject.keywordAuthor | Minimal symptom expression | - |
dc.subject.keywordAuthor | Acetylcholine receptor | - |
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