Switching to tenofovir vs continuing entecavir for hepatitis B virus with partial virologic response to entecavir: a randomized controlled trial
DC Field | Value | Language |
---|---|---|
dc.contributor.author | Yim, Hyung Joon | - |
dc.contributor.author | Kim, In Hee | - |
dc.contributor.author | Suh, Sang Jun | - |
dc.contributor.author | Jung, Young Kul | - |
dc.contributor.author | Kim, Ji Hoon | - |
dc.contributor.author | Seo, Yeon Seok | - |
dc.contributor.author | Yeon, Jong Eun | - |
dc.contributor.author | Kim, C. W. | - |
dc.contributor.author | Kwon, S. Y. | - |
dc.contributor.author | Park, S. H. | - |
dc.contributor.author | Lee, M. S. | - |
dc.contributor.author | Um, Soon Ho | - |
dc.contributor.author | Byun, Kwan Soo | - |
dc.date.available | 2020-11-02T06:55:33Z | - |
dc.date.issued | 2018-11 | - |
dc.identifier.issn | 1352-0504 | - |
dc.identifier.issn | 1365-2893 | - |
dc.identifier.uri | https://scholarworks.korea.ac.kr/kumedicine/handle/2020.sw.kumedicine/2960 | - |
dc.description.abstract | Entecavir 0.5mg (ETV) is widely used among treatment-naive chronic hepatitis B (CHB) patients. However, 10%-30% of patients show partial virologic response (PVR) to the drug. If the hepatitis B virus (HBV) continues to replicate, the underlying liver disease may progress. Herein, we compared the efficacy of switching to tenofovir disoproxil fumarate (TDF) with that of continuing ETV in CHB patients with PVR to ETV. This was an open-label randomized controlled trial including CHB patients who had been receiving 0.5mg of ETV for >12months, but who still had detectable HBV DNA levels of >60IU/mL without known resistance to ETV. Sixty patients were enrolled and 45 qualified for the study: Twenty-two patients were randomly assigned into the TDF group and 23 into the ETV group. After 12months of treatment, the virologic response rate (HBV DNA <20IU/mL) was significantly higher in the TDF group than in the ETV group, as measured using per-protocol analysis (55% vs 20%; P=.022) and intention-to-treat analysis (50% vs 17.4%; P=.020). The reduction in HBV DNA was greater (-1.13 vs -0.67 log(10) IU/mL; P=.024), and the mean HBV DNA level was lower (1.54 vs 2.01 log(10) IU/mL; P=.011) in the TDF group than in the ETV group. In conclusion, to achieve optimal response in CHB patients with PVR to ETV, switching to TDF would be a better strategy than continuing ETV. Appropriate modification of therapy would further improve the outcome of chronic HBV infection. | - |
dc.format.extent | 10 | - |
dc.language | 영어 | - |
dc.language.iso | ENG | - |
dc.publisher | Blackwell Publishing Inc. | - |
dc.title | Switching to tenofovir vs continuing entecavir for hepatitis B virus with partial virologic response to entecavir: a randomized controlled trial | - |
dc.type | Article | - |
dc.publisher.location | 미국 | - |
dc.identifier.doi | 10.1111/jvh.12934 | - |
dc.identifier.scopusid | 2-s2.0-85055463448 | - |
dc.identifier.wosid | 000448283100012 | - |
dc.identifier.bibliographicCitation | Journal of Viral Hepatitis, v.25, no.11, pp 1321 - 1330 | - |
dc.citation.title | Journal of Viral Hepatitis | - |
dc.citation.volume | 25 | - |
dc.citation.number | 11 | - |
dc.citation.startPage | 1321 | - |
dc.citation.endPage | 1330 | - |
dc.type.docType | Article | - |
dc.description.isOpenAccess | N | - |
dc.description.journalRegisteredClass | sci | - |
dc.description.journalRegisteredClass | scie | - |
dc.description.journalRegisteredClass | scopus | - |
dc.relation.journalResearchArea | Gastroenterology & Hepatology | - |
dc.relation.journalResearchArea | Infectious Diseases | - |
dc.relation.journalResearchArea | Virology | - |
dc.relation.journalWebOfScienceCategory | Gastroenterology & Hepatology | - |
dc.relation.journalWebOfScienceCategory | Infectious Diseases | - |
dc.relation.journalWebOfScienceCategory | Virology | - |
dc.subject.keywordPlus | REDUCES HEPATOCELLULAR-CARCINOMA | - |
dc.subject.keywordPlus | DISOPROXIL FUMARATE | - |
dc.subject.keywordPlus | NAIVE PATIENTS | - |
dc.subject.keywordPlus | RISK | - |
dc.subject.keywordPlus | THERAPY | - |
dc.subject.keywordPlus | MONOTHERAPY | - |
dc.subject.keywordPlus | LAMIVUDINE | - |
dc.subject.keywordPlus | CIRRHOSIS | - |
dc.subject.keywordPlus | EFFICACY | - |
dc.subject.keywordPlus | COMBINATION | - |
dc.subject.keywordAuthor | chronic hepatitis B | - |
dc.subject.keywordAuthor | entecavir | - |
dc.subject.keywordAuthor | partial virologic response | - |
dc.subject.keywordAuthor | tenofovir | - |
dc.subject.keywordAuthor | treatment | - |
Items in ScholarWorks are protected by copyright, with all rights reserved, unless otherwise indicated.
73, Goryeodae-ro, Seongbuk-gu, Seoul, Republic of Korea (02841)82-2-2286-1265
COPYRIGHT 2020 KOREA UNIVERSITY MEDICAL LIBRARY ALL RIGHTS RESERVED.
Certain data included herein are derived from the © Web of Science of Clarivate Analytics. All rights reserved.
You may not copy or re-distribute this material in whole or in part without the prior written consent of Clarivate Analytics.