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A 96-week randomized trial of switching to entecavir in chronic hepatitis B patients with a partial virological response to lamivudine

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dc.contributor.authorHeo, Jeong-
dc.contributor.authorPark, Jun Yong-
dc.contributor.authorLee, Heon Ju-
dc.contributor.authorTak, Won Young-
dc.contributor.authorUm, Soon Ho-
dc.contributor.authorKim, Do Young-
dc.contributor.authorYoon, Ki Tae-
dc.contributor.authorPark, Soo Young-
dc.contributor.authorSeo, Yeon Seok-
dc.contributor.authorHan, Kwang-Hyub-
dc.contributor.authorCho, Mong-
dc.contributor.authorAhn, Sang Hoon-
dc.date.available2020-11-10T11:59:34Z-
dc.date.issued2012-08-
dc.identifier.issn1359-6535-
dc.identifier.issn2040-2058-
dc.identifier.urihttps://scholarworks.korea.ac.kr/kumedicine/handle/2020.sw.kumedicine/30856-
dc.description.abstractBackground: Growing numbers of chronic hepatitis B (CHB) patients in the Asia-Pacific region have failed first-line therapy with low genetic barrier drugs. This prospective, 96-week study investigated the antiviral efficacy, safety and tolerability of switching to entecavir versus maintaining lamivudine in CHB patients with a partial virological response to lamivudine. Methods: A total of 72 hepatitis B e antigen (HBeAg)-positive patients, with serum HBV DNA >= 60 IU/ml after >= 6 months lamivudine monotherapy were randomized 1:1 to receive either entecavir 1.0 mg/day, or continued lamivudine 100 mg/day. Results: Mean duration of prior lamivudine treatment was 15.1 months in the lamivudine-maintained patients and 16.1 months in the entecavir-switch patients, with mean baseline HBV DNA levels of 4.66 and 4.55 log(10) IU/ml, respectively. A greater proportion of entecavirswitch than lamivudine-maintained patients achieved undetectable HBV DNA at all time points (67.6% versus 11.4% at week 96; P<0.001). Entecavir-switch patients achieved a greater mean decrease in HBV DNA level by week 4, maintained through week 96. Entecavir-switch patients with baseline HBV DNA<5 log(10) IU/ml were more likely to achieve a virological response at week 96. A total of 6 (17.6%) entecavir-switch and 2 (5.7%) lamivudine-maintained patients achieved HBeAg loss, and 3 (8.8%) entecavir and 1 (2.9%) lamivudine patients achieved HBeAg seroconversion. Genotypic resistance to the assigned intervention emerged in 82.9% (29/35) of lamivudine-maintained patients, and in 3% (1/34) of entecavir-switch patients after 96 weeks. Conclusions: Switching to entecavir in patients with a partial virological response to lamivudine resulted in increased virological efficacy and lower rates of antiviral resistance than maintaining lamivudine.-
dc.format.extent8-
dc.language영어-
dc.language.isoENG-
dc.publisherINT MEDICAL PRESS LTD-
dc.titleA 96-week randomized trial of switching to entecavir in chronic hepatitis B patients with a partial virological response to lamivudine-
dc.typeArticle-
dc.publisher.location영국-
dc.identifier.doi10.3851/IMP2277-
dc.identifier.scopusid2-s2.0-84871894884-
dc.identifier.wosid000208835300010-
dc.identifier.bibliographicCitationANTIVIRAL THERAPY, v.17, no.8, pp 1563 - 1570-
dc.citation.titleANTIVIRAL THERAPY-
dc.citation.volume17-
dc.citation.number8-
dc.citation.startPage1563-
dc.citation.endPage1570-
dc.type.docTypeArticle-
dc.description.isOpenAccessY-
dc.description.journalRegisteredClasssci-
dc.description.journalRegisteredClassscie-
dc.description.journalRegisteredClassscopus-
dc.relation.journalResearchAreaInfectious Diseases-
dc.relation.journalResearchAreaPharmacology & Pharmacy-
dc.relation.journalResearchAreaVirology-
dc.relation.journalWebOfScienceCategoryInfectious Diseases-
dc.relation.journalWebOfScienceCategoryPharmacology & Pharmacy-
dc.relation.journalWebOfScienceCategoryVirology-
dc.subject.keywordPlusLONG-TERM LAMIVUDINE-
dc.subject.keywordPlusVIRUS-INFECTION-
dc.subject.keywordPlusGENOTYPE-C-
dc.subject.keywordPlusTHERAPY-
dc.subject.keywordPlusMANAGEMENT-
dc.subject.keywordPlusRISK-
dc.subject.keywordPlusPREVALENCE-
dc.subject.keywordPlusHEALTH-
dc.subject.keywordPlusSAFETY-
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Anam Hospital (Department of Gastroenterology and Hepatology, Anam Hospital)
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