Risk factors of lymph node metastasis after non-curative endoscopic resection of undifferentiated-type early gastric cancer
DC Field | Value | Language |
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dc.contributor.author | Yang, Hyo-Joon | - |
dc.contributor.author | Jang, Jae-Young | - |
dc.contributor.author | Kim, Sang Gyun | - |
dc.contributor.author | Ahn, Ji Yong | - |
dc.contributor.author | Nam, Su Youn | - |
dc.contributor.author | Kim, Jie-Hyun | - |
dc.contributor.author | Min, Byung-Hoon | - |
dc.contributor.author | Lee, Wan-Sik | - |
dc.contributor.author | Lee, Bong Eun | - |
dc.contributor.author | Joo, Moon Kyung | - |
dc.contributor.author | Park, Jae Myung | - |
dc.contributor.author | Shin, Woon Geon | - |
dc.contributor.author | Lee, Hang Lak | - |
dc.contributor.author | Gweon, Tae-Geun | - |
dc.contributor.author | Park, Moo In | - |
dc.contributor.author | Choi, Jeongmin | - |
dc.contributor.author | Tae, Chung Hyun | - |
dc.contributor.author | Kim, Young-Il | - |
dc.contributor.author | Choi, Il Ju | - |
dc.date.available | 2020-12-09T08:52:44Z | - |
dc.date.issued | 2021-01 | - |
dc.identifier.issn | 1436-3291 | - |
dc.identifier.issn | 1436-3305 | - |
dc.identifier.uri | https://scholarworks.korea.ac.kr/kumedicine/handle/2020.sw.kumedicine/33912 | - |
dc.description.abstract | Background This study aimed to investigate risk factors for lymph node (LN) or distant metastasis after non-curative endoscopic resection (ER) of undifferentiated-type early gastric cancer (EGC). Methods Of 1124 patients who underwent ER for undifferentiated-type gastric cancer at 18 tertiary hospitals across six geographic areas in Korea between 2005 and 2014, 634 with non-curative ER beyond the expanded criteria were retrospectively enrolled. According to the treatment after ER, patients were divided into additional surgery (n = 270) and follow-up (n = 364) groups. The median follow-up duration was 59 months for recurrence and 84 months for mortality. Results LN metastasis was found in 6.7% (18/270) of patients at surgery. Ulcer [odds ratio (OR) 3.83; 95% confidence interval (CI) 1.21–12.13; p = 0.022] and submucosal invasion (OR 10.35; 95% CI 1.35–79.48; p = 0.025) were independent risk factors. In the follow-up group, seven patients (1.9%) developed LN or distant recurrence. Ulcer [hazard ratio (HR) 7.60; 95% CI 1.39–35.74; p = 0.018], LVI (HR 6.80; 95% CI 1.07–42.99; p = 0.042), and positive vertical margin (HR 6.71; 95% CI 1.28–35.19; p = 0.024) were independent risk factors. In the overall cohort, LN metastasis rates were 9.6% in patients with two or more risk factors and 1.2% in those with no or one risk factor. Conclusions LVI, ulcer, submucosal invasion, and positive vertical margin are independently associated with LN or distant metastasis after non-curative ER of undifferentiated-type EGC. Surgical resection is strongly recommended for patients with two or more risk factors. | - |
dc.format.extent | 11 | - |
dc.language | 영어 | - |
dc.language.iso | ENG | - |
dc.publisher | SPRINGER | - |
dc.title | Risk factors of lymph node metastasis after non-curative endoscopic resection of undifferentiated-type early gastric cancer | - |
dc.type | Article | - |
dc.publisher.location | 미국 | - |
dc.identifier.doi | 10.1007/s10120-020-01103-2 | - |
dc.identifier.scopusid | 2-s2.0-85087445098 | - |
dc.identifier.wosid | 000545310300002 | - |
dc.identifier.bibliographicCitation | Gastric Cancer, v.24, no.1, pp 168 - 178 | - |
dc.citation.title | Gastric Cancer | - |
dc.citation.volume | 24 | - |
dc.citation.number | 1 | - |
dc.citation.startPage | 168 | - |
dc.citation.endPage | 178 | - |
dc.type.docType | Article; Early Access | - |
dc.description.isOpenAccess | N | - |
dc.description.journalRegisteredClass | scie | - |
dc.description.journalRegisteredClass | scopus | - |
dc.relation.journalResearchArea | Oncology | - |
dc.relation.journalResearchArea | Gastroenterology & Hepatology | - |
dc.relation.journalWebOfScienceCategory | Oncology | - |
dc.relation.journalWebOfScienceCategory | Gastroenterology & Hepatology | - |
dc.subject.keywordPlus | POORLY DIFFERENTIATED ADENOCARCINOMA | - |
dc.subject.keywordPlus | SUBMUCOSAL DISSECTION | - |
dc.subject.keywordPlus | PREDICTIVE FACTORS | - |
dc.subject.keywordPlus | FEASIBILITY | - |
dc.subject.keywordPlus | OUTCOMES | - |
dc.subject.keywordPlus | SURGERY | - |
dc.subject.keywordAuthor | Stomach neoplasms | - |
dc.subject.keywordAuthor | Undifferentiated-type histology | - |
dc.subject.keywordAuthor | Non-curative resection | - |
dc.subject.keywordAuthor | Lymph node Metastasis | - |
dc.subject.keywordAuthor | Risk factors | - |
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