Validation of risk prediction scores for hepatocellular carcinoma in patients with chronic hepatitis B treated with entecavir or tenofovir
DC Field | Value | Language |
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dc.contributor.author | Chang, Jin Won | - |
dc.contributor.author | Lee, Jae Seung | - |
dc.contributor.author | Lee, Hye Won | - |
dc.contributor.author | Kim, Beom Kyung | - |
dc.contributor.author | Park, Jun Yong | - |
dc.contributor.author | Kim, Do Young | - |
dc.contributor.author | Ahn, Sang Hoon | - |
dc.contributor.author | Seo, Yeon Seok | - |
dc.contributor.author | Lee, Han Ah | - |
dc.contributor.author | Kim, Mi Na | - |
dc.contributor.author | Lee, Yu Rim | - |
dc.contributor.author | Hwang, Seong Gyu | - |
dc.contributor.author | Rim, Kyu Sung | - |
dc.contributor.author | Um, Soon Ho | - |
dc.contributor.author | Tak, Won Young | - |
dc.contributor.author | Kweon, Young Oh | - |
dc.contributor.author | Park, Soo Young | - |
dc.contributor.author | Kim, Seung Up | - |
dc.date.available | 2020-12-09T08:54:30Z | - |
dc.date.issued | 2021-01 | - |
dc.identifier.issn | 1352-0504 | - |
dc.identifier.issn | 1365-2893 | - |
dc.identifier.uri | https://scholarworks.korea.ac.kr/kumedicine/handle/2020.sw.kumedicine/33978 | - |
dc.description.abstract | Several prediction scores for the early detection of hepatocellular carcinoma (HCC) are available. We validated the predictive accuracy of age, albumin, sex, liver cirrhosis (AASL), RESCUE-B, PAGE-B and modified PAGE-B (mPAGE-B) scores in chronic hepatitis B (CHB) patients treated with entecavir (ETV) or tenofovir disoproxil fumarate (TDF). Between 2007 and 2014, 3171 patients were recruited (1645, ETV; 1517, TDF). The predictive accuracy of each prediction score was assessed. The mean age of the study population (1977 men; 1194 women) was 48.8 years. Liver cirrhosis was present in 1040 (32.8%) patients. During follow-up (median, 58.2 months), 280 (8.8%) patients developed HCC; these patients were significantly older; more likely to be male; had significantly higher proportions of liver cirrhosis, hypertension and diabetes; and had significantly higher values for the four risk scores than those who did not develop HCC (allP < .05). Older age (hazard ratio [HR] = 1.048), male sex (HR = 2.142), liver cirrhosis (HR = 3.144) and prolonged prothrombin time (HR = 2.589) were independently associated with an increased risk of HCC (allP < .05), whereas a higher platelet count (HR = 0.996) was independently associated with a decreased risk of HCC (P < .05). The predictive accuracy of AASL score was the highest for 3- and 5-year HCC predictions (areas under the curve [AUCs] = 0.818 and 0.816, respectively), followed by RESCUE-B, PAGE-B and mPAGE-B scores (AUC = 0.780-0.815 and 0.769-0.814, respectively). In conclusion, four HCC prediction scores were assessed in Korean CHB patients treated with ETV or TDF. The AASL score showed the highest predictive accuracy. | - |
dc.format.extent | 10 | - |
dc.language | 영어 | - |
dc.language.iso | ENG | - |
dc.publisher | WILEY | - |
dc.title | Validation of risk prediction scores for hepatocellular carcinoma in patients with chronic hepatitis B treated with entecavir or tenofovir | - |
dc.type | Article | - |
dc.publisher.location | 미국 | - |
dc.identifier.doi | 10.1111/jvh.13411 | - |
dc.identifier.scopusid | 2-s2.0-85092180683 | - |
dc.identifier.wosid | 000575785900001 | - |
dc.identifier.bibliographicCitation | JOURNAL OF VIRAL HEPATITIS, v.28, no.1, pp 95 - 104 | - |
dc.citation.title | JOURNAL OF VIRAL HEPATITIS | - |
dc.citation.volume | 28 | - |
dc.citation.number | 1 | - |
dc.citation.startPage | 95 | - |
dc.citation.endPage | 104 | - |
dc.type.docType | Article; Early Access | - |
dc.description.isOpenAccess | N | - |
dc.description.journalRegisteredClass | scie | - |
dc.description.journalRegisteredClass | scopus | - |
dc.relation.journalResearchArea | Gastroenterology & Hepatology | - |
dc.relation.journalResearchArea | Infectious Diseases | - |
dc.relation.journalResearchArea | Virology | - |
dc.relation.journalWebOfScienceCategory | Gastroenterology & Hepatology | - |
dc.relation.journalWebOfScienceCategory | Infectious Diseases | - |
dc.relation.journalWebOfScienceCategory | Virology | - |
dc.subject.keywordPlus | CLINICAL-PRACTICE GUIDELINES | - |
dc.subject.keywordPlus | NATURAL-HISTORY | - |
dc.subject.keywordPlus | SCORING SYSTEM | - |
dc.subject.keywordPlus | MANAGEMENT | - |
dc.subject.keywordPlus | CIRRHOSIS | - |
dc.subject.keywordPlus | GENOTYPES | - |
dc.subject.keywordPlus | THERAPY | - |
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