Nasopharyngeal carriage rate and serotypes of Streptococcus pneumoniae and antimicrobial susceptibility in healthy Korean children younger than 5 years old: Focus on influence of pneumococcal conjugate vaccination
DC Field | Value | Language |
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dc.contributor.author | Lee E.K. | - |
dc.contributor.author | Jun J.K. | - |
dc.contributor.author | Choi U.Y. | - |
dc.contributor.author | Kwon H.-J. | - |
dc.contributor.author | Kim K.-H. | - |
dc.contributor.author | Kang J.H. | - |
dc.date.available | 2020-12-09T09:43:30Z | - |
dc.date.issued | 2013 | - |
dc.identifier.issn | 2093-2340 | - |
dc.identifier.issn | 2092-6448 | - |
dc.identifier.uri | https://scholarworks.korea.ac.kr/kumedicine/handle/2020.sw.kumedicine/34985 | - |
dc.description.abstract | Background: Even after pneumococcal vaccination introduction, Streptococcus pneumoniae (pneumoccocus) is still an important cause of respiratory and invasive severe infection. Pneumococcus is resided in nasal mucosa and local or systemic infection begins with the nasal mucosa damage. We studied the indirect effect of pneumococcal conjugate vaccine (PCV) on pneumococcal nasopharyngeal carriage rates, serotypes and antimicrobial susceptibility between vaccinate and non-vaccinated children. Materials and Methods: From January 2010 to October 2010, 379 healthy children under 5 years old from three university hospitals were recruited. Fully vaccinated children over 3 time doses of PCV and children with no vaccination history of PCV were enrolled, and nasopharyngeal aspirations were obtained from these children. Serotypes using multibead serotyping assay with multiplex PCR and antimicrobial susceptibility was analyzed. Antimicrobial susceptibilities were determined by the CLIS guideline. Results: Two hundred seventy six children were received pneumococcal vaccination while 103 were not. 137 pneumococci were isolated from nasopharyngeal aspiration specimens. Nasal carriage rate was significantly low in vaccinated group (P -value; 0.001). Nasopharyngeal carriage rate was 28.6% (79/276) in vaccinate group and 56.3% (58/103) in non-vaccinated group. Among those vaccinated group, 13.0% (36/276) of the serotypes were vaccine or vaccine related type with the most common type 19F. In contrast, 31.1% (32/103) of the serotypes in non vaccinated group were vaccine or vaccine related type with the most common type 6A. The resistant rate of penicillin was 90.5%. For antimicrobial susceptibility, amoxicillin and amoxicillin/ clavulanate showed high susceptibility (73.0%), but 19F and 19A serotypes were all resistant against amoxicillin. Conclusions: High nasopharyngeal carriage rate in non vaccinated group corresponded to the result of past study. However, 19F and 19A still came up as problematic serotypes with a high carriage rate and antimicrobial resistance in both vaccinated and non vaccinated groups. Also, this study showed that the resistance rate of primary oral antimicrobial agents was increased in compared to past. For solving these problems, the selective antimicrobial use with establishment of high dose amoxicillin/ clavulanate regimen and active PCV immunization should be needed. Furthermore, pneumococcal carriage and serotype study concerning with antimicrobial susceptibility should be conducted in the future in 10 or 13-valent PCV received children. © 2013 by The Korean Society of Infectious Diseases. | - |
dc.format.extent | 9 | - |
dc.language | 영어 | - |
dc.language.iso | ENG | - |
dc.title | Nasopharyngeal carriage rate and serotypes of Streptococcus pneumoniae and antimicrobial susceptibility in healthy Korean children younger than 5 years old: Focus on influence of pneumococcal conjugate vaccination | - |
dc.type | Article | - |
dc.publisher.location | 대한민국 | - |
dc.identifier.doi | 10.3947/ic.2013.45.1.76 | - |
dc.identifier.scopusid | 2-s2.0-84879126964 | - |
dc.identifier.bibliographicCitation | Infection and Chemotherapy, v.45, no.1, pp 76 - 84 | - |
dc.citation.title | Infection and Chemotherapy | - |
dc.citation.volume | 45 | - |
dc.citation.number | 1 | - |
dc.citation.startPage | 76 | - |
dc.citation.endPage | 84 | - |
dc.type.docType | Article | - |
dc.description.isOpenAccess | Y | - |
dc.description.journalRegisteredClass | scopus | - |
dc.description.journalRegisteredClass | kci | - |
dc.subject.keywordPlus | amoxicillin | - |
dc.subject.keywordPlus | amoxicillin plus clavulanic acid | - |
dc.subject.keywordPlus | cefaclor | - |
dc.subject.keywordPlus | cefdinir | - |
dc.subject.keywordPlus | clarithromycin | - |
dc.subject.keywordPlus | penicillin derivative | - |
dc.subject.keywordPlus | Pneumococcus vaccine | - |
dc.subject.keywordPlus | antibiotic sensitivity | - |
dc.subject.keywordPlus | article | - |
dc.subject.keywordPlus | bacterium isolation | - |
dc.subject.keywordPlus | child | - |
dc.subject.keywordPlus | drug megadose | - |
dc.subject.keywordPlus | female | - |
dc.subject.keywordPlus | human | - |
dc.subject.keywordPlus | infant | - |
dc.subject.keywordPlus | Korea | - |
dc.subject.keywordPlus | major clinical study | - |
dc.subject.keywordPlus | male | - |
dc.subject.keywordPlus | minimum inhibitory concentration | - |
dc.subject.keywordPlus | multiplex polymerase chain reaction | - |
dc.subject.keywordPlus | nasopharyngeal aspiration | - |
dc.subject.keywordPlus | nasopharynx | - |
dc.subject.keywordPlus | nose cavity | - |
dc.subject.keywordPlus | preschool child | - |
dc.subject.keywordPlus | serotype | - |
dc.subject.keywordPlus | Streptococcus pneumoniae | - |
dc.subject.keywordPlus | vaccination | - |
dc.subject.keywordAuthor | Antimicrobial resistance | - |
dc.subject.keywordAuthor | Oral antimicrobial | - |
dc.subject.keywordAuthor | Pneumococcal conjugate vaccine | - |
dc.subject.keywordAuthor | Serotype | - |
dc.subject.keywordAuthor | Streptococcus pneumoniae | - |
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