The association of chronic air pollutants with coronary artery spasm, vasospastic angina, and endothelial dysfunction
DC Field | Value | Language |
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dc.contributor.author | Choi, Byoung Geol | - |
dc.contributor.author | Lee, Jiwon | - |
dc.contributor.author | Kim, Suhng Wook | - |
dc.contributor.author | Lee, Min Woo | - |
dc.contributor.author | Baek, Man Jong | - |
dc.contributor.author | Ryu, Yang Gi | - |
dc.contributor.author | Choi, Se Yeon | - |
dc.contributor.author | Byun, Jae Kyeong | - |
dc.contributor.author | Mashaly, Ahmed | - |
dc.contributor.author | Park, Yoonjee | - |
dc.contributor.author | Jang, Won Young | - |
dc.contributor.author | Kim, Woohyeun | - |
dc.contributor.author | Choi, Jah Yeon | - |
dc.contributor.author | Park, Eun Jin | - |
dc.contributor.author | Na, Jin Oh | - |
dc.contributor.author | Choi, Cheol Ung | - |
dc.contributor.author | Lim, Hong Euy | - |
dc.contributor.author | Kim, Eung Ju | - |
dc.contributor.author | Park, Chang Gyu | - |
dc.contributor.author | Seo, Hong Seog | - |
dc.contributor.author | Oh, Dong Joo | - |
dc.contributor.author | Rha, Seung-Woon | - |
dc.date.available | 2020-11-02T07:16:00Z | - |
dc.date.issued | 2018-06 | - |
dc.identifier.issn | 0954-6928 | - |
dc.identifier.issn | 1473-5830 | - |
dc.identifier.uri | https://scholarworks.korea.ac.kr/kumedicine/handle/2020.sw.kumedicine/3502 | - |
dc.description.abstract | Background We evaluated the effect of chronic exposure to air pollutants (APs) on coronary endothelial function and significant coronary artery spasm (CAS) as assessed by intracoronary acetylcholine (ACH) provocation test. Patients and methods A total of 6430 patients with typical or atypical chest pain who underwent intracoronary ACH provocation test were enrolled. We obtained data on APs from the Korean National Institute of Environmental Research (http://www.nier.go.kr/). APs are largely divided into two types: particulate matter with aerodynamic diameter of less than or equal to 10 mu m in size (PM10) and gaseous pollutants such as nitrogen dioxide, sulfur dioxide, carbon monoxide, and ozone. The primary endpoint is the incidence of significant CAS and its associated parameters during ACH provocation test. Results The incidence of CAS was positively correlated with an exposure duration of PM10, whereas nitrogen dioxide, sulfur dioxide, carbon monoxide, and ozone were shown to be unrelated to CAS. During the ACH provocation test, as PM10 increased, the frequency of CAS was increased, and the incidence of transient ST-segment elevation was also increased. There was a trend toward higher incidence of spontaneous spasm as PM10 increased. The mean exposure level of PM10 was 51.3 +/- 25.4 mu g/m(3). The CAS risk increased by 4% when the level of PM10 increased by 20 mu g/m(3) by an adjusted Cox regression analysis. Conclusion CAS incidence is closely related to exposure to PMs but not to gaseous pollutants. Particularly, higher exposure concentrations and longer exposure duration of PM10 increased the risk of CAS. These important findings provide a plausible mechanism that links air pollution to vasospastic angina and provide new insights into environmental factors. Copyright (C) 2018 Wolters Kluwer Health, Inc. All rights reserved. | - |
dc.format.extent | 8 | - |
dc.language | 영어 | - |
dc.language.iso | ENG | - |
dc.publisher | LIPPINCOTT WILLIAMS & WILKINS | - |
dc.title | The association of chronic air pollutants with coronary artery spasm, vasospastic angina, and endothelial dysfunction | - |
dc.type | Article | - |
dc.publisher.location | 미국 | - |
dc.identifier.doi | 10.1097/MCA.0000000000000603 | - |
dc.identifier.scopusid | 2-s2.0-85046552151 | - |
dc.identifier.wosid | 000431298000010 | - |
dc.identifier.bibliographicCitation | CORONARY ARTERY DISEASE, v.29, no.4, pp 336 - 343 | - |
dc.citation.title | CORONARY ARTERY DISEASE | - |
dc.citation.volume | 29 | - |
dc.citation.number | 4 | - |
dc.citation.startPage | 336 | - |
dc.citation.endPage | 343 | - |
dc.type.docType | Article | - |
dc.description.isOpenAccess | N | - |
dc.description.journalRegisteredClass | sci | - |
dc.description.journalRegisteredClass | scie | - |
dc.description.journalRegisteredClass | scopus | - |
dc.relation.journalResearchArea | Cardiovascular System & Cardiology | - |
dc.relation.journalWebOfScienceCategory | Cardiac & Cardiovascular Systems | - |
dc.subject.keywordPlus | ISCHEMIC-HEART-DISEASE | - |
dc.subject.keywordPlus | HOSPITAL ADMISSIONS | - |
dc.subject.keywordPlus | CLINICAL-OUTCOMES | - |
dc.subject.keywordPlus | BLOOD MARKERS | - |
dc.subject.keywordPlus | TERM EXPOSURE | - |
dc.subject.keywordPlus | POLLUTION | - |
dc.subject.keywordPlus | EVENTS | - |
dc.subject.keywordPlus | IMPACT | - |
dc.subject.keywordAuthor | air pollution | - |
dc.subject.keywordAuthor | angina | - |
dc.subject.keywordAuthor | coronary artery disease | - |
dc.subject.keywordAuthor | coronary artery spasm | - |
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