Expression of HAT1 and HDAC1, 2, 3 in Diffuse Large B-Cell Lymphomas, Peripheral T-Cell Lymphomas, and NK/T-Cell Lymphomas
DC Field | Value | Language |
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dc.contributor.author | Min, Soo Kee | - |
dc.contributor.author | Koh, Young Ho | - |
dc.contributor.author | Park, Yunwoong | - |
dc.contributor.author | Kim, Hyo Jung | - |
dc.contributor.author | Seo, Jinwon | - |
dc.contributor.author | Park, Hye-Rim | - |
dc.contributor.author | Cho, Seong Jin | - |
dc.contributor.author | Kim, In Sun | - |
dc.date.available | 2020-12-09T09:44:00Z | - |
dc.date.issued | 2012-04 | - |
dc.identifier.issn | 1738-1843 | - |
dc.identifier.issn | 2092-8920 | - |
dc.identifier.uri | https://scholarworks.korea.ac.kr/kumedicine/handle/2020.sw.kumedicine/35083 | - |
dc.description.abstract | Background: It has generally been proven that histone acetylation and deacetylation are involved in the malignant transformation. To date, however, this has rarely been studied in cases of malignant lymphoma. Methods: We studied nine cases of reactive lymphoid hyperplasia, 78 cases of diffuse large B-cell lymphoma (DLBCL), 13 cases of peripheral T-cell lymphoma, not otherwise specified (PTCL-NOS), and 13 cases of extranodal NK/T-cell lymphoma, nasal type (NKTCL). Thus, we attempted to elucidate the associations of the degree of the expression of histone acetyltransferase 1 (HAT1), histone deacetylase (HDAC) 1, HDAC2, and HDAC3 with the clinical behaviors of above malignant lymphomas using the immunohistochemistry and a western blot analysis. Results: The degree of the expression of HAT1 was higher in cases of DLBCL, PTCL-NOS or NKTCL as compared with reactive lymphoid hyperplasia (p<0.05). The degree of the expression of HAT1 was correlated with that of HDAC1 in cases of DLBCL or NKTCL (p<0.05). The degree of the expression of HAT1 and HDAC1 was correlated with a poor survival in cases of DLBCL or PTCL-NOS (p>0.05). Conclusions: HAT1, HDAC1, and HDAC2 play a critical role in the development of malignant lymphomas. Both HAT1 and HDAC1 might be indicators for a poor prognosis in cases of DLBCL as cooperating factors. | - |
dc.format.extent | 9 | - |
dc.language | 영어 | - |
dc.language.iso | ENG | - |
dc.publisher | KOREAN SOCIETY PATHOLOGISTS | - |
dc.title | Expression of HAT1 and HDAC1, 2, 3 in Diffuse Large B-Cell Lymphomas, Peripheral T-Cell Lymphomas, and NK/T-Cell Lymphomas | - |
dc.type | Article | - |
dc.publisher.location | 대한민국 | - |
dc.identifier.doi | 10.4132/KoreanJPathol.2012.46.2.142 | - |
dc.identifier.scopusid | 2-s2.0-84863444110 | - |
dc.identifier.wosid | 000303641700006 | - |
dc.identifier.bibliographicCitation | KOREAN JOURNAL OF PATHOLOGY, v.46, no.2, pp 142 - 150 | - |
dc.citation.title | KOREAN JOURNAL OF PATHOLOGY | - |
dc.citation.volume | 46 | - |
dc.citation.number | 2 | - |
dc.citation.startPage | 142 | - |
dc.citation.endPage | 150 | - |
dc.type.docType | Article | - |
dc.identifier.kciid | ART001654405 | - |
dc.description.isOpenAccess | N | - |
dc.description.journalRegisteredClass | scie | - |
dc.description.journalRegisteredClass | scopus | - |
dc.description.journalRegisteredClass | kci | - |
dc.relation.journalResearchArea | Pathology | - |
dc.relation.journalWebOfScienceCategory | Pathology | - |
dc.subject.keywordPlus | ACETYLATED HISTONE H4 | - |
dc.subject.keywordPlus | GASTRIC-CANCER | - |
dc.subject.keywordPlus | COLON-CANCER | - |
dc.subject.keywordPlus | DEACETYLASE-1 | - |
dc.subject.keywordPlus | INHIBITORS | - |
dc.subject.keywordPlus | RECRUITMENT | - |
dc.subject.keywordPlus | REPRESSION | - |
dc.subject.keywordPlus | CADHERIN | - |
dc.subject.keywordPlus | COMPLEX | - |
dc.subject.keywordAuthor | Acetylation | - |
dc.subject.keywordAuthor | Deacetylation | - |
dc.subject.keywordAuthor | Histone deacetylase inhibitors | - |
dc.subject.keywordAuthor | Lymphoma | - |
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