Patterns of Skin and Soft Tissue Metastases from Breast Cancer according to Subtypes: Relationship between EGFR Overexpression and Skin Manifestations
DC Field | Value | Language |
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dc.contributor.author | Kong, Jee Hyun | - |
dc.contributor.author | Park, Yeon Hee | - |
dc.contributor.author | Kim, Jung A. | - |
dc.contributor.author | Kim, Jeong Hoon | - |
dc.contributor.author | Yun, Jina | - |
dc.contributor.author | Sun, Jong Mu | - |
dc.contributor.author | Won, Young Woong | - |
dc.contributor.author | Lee, Soo Hyeon | - |
dc.contributor.author | Kim, Seung Tae | - |
dc.contributor.author | Cho, Eun Yoon | - |
dc.contributor.author | Ahn, Jin Seok | - |
dc.contributor.author | Im, Young Hyuck | - |
dc.date.available | 2020-12-09T10:01:23Z | - |
dc.date.issued | 2011-01 | - |
dc.identifier.issn | 0030-2414 | - |
dc.identifier.issn | 1423-0232 | - |
dc.identifier.uri | https://scholarworks.korea.ac.kr/kumedicine/handle/2020.sw.kumedicine/35265 | - |
dc.description.abstract | Objectives: We evaluated whether skin changes and soft tissue infiltration patterns reflect breast cancer subtypes based on the breast hormonal receptor (HR) and human epidermal growth factor receptor 2 (HER2) status at the time of skin metastasis. Methods: We retrospectively reviewed the patients’ medical records with radiologic imaging studies. Results: The numbers of patients of each subtype were as follows: HR positive (HR+ve) 53 (42.4%), HER2 enriched 43 (34.4%), and triple negative (TN) 29 (23.2%). The presence of skin ulceration was found more commonly in the HR+ve group than in the others (57.1% for HR+ve vs. 25% for HER2 enriched vs. 15.4% for TN, p = 0.019). Erythematous infiltrations were shown predominantly in the TN group (19.0 vs. 54.2 vs. 84.6%, respectively, p < 0.000). On CT scans, soft tissue infiltration appeared to be more common in the HER2-enriched and TN groups than in the HR+ve group (24.5 vs. 41.9 vs. 48.3%, respectively, p = 0.013). Erythematous infiltrative lesions were more common in patients with epidermal growth factor receptor overexpression (p = 0.036). Conclusion: The patterns of skin involvement including surrounding soft tissue infiltration may reflect breast cancer subtype. Prospective evaluation is necessary to confirm their influential effect on breast cancer subtypes. | - |
dc.format.extent | 8 | - |
dc.language | 영어 | - |
dc.language.iso | ENG | - |
dc.publisher | KARGER | - |
dc.title | Patterns of Skin and Soft Tissue Metastases from Breast Cancer according to Subtypes: Relationship between EGFR Overexpression and Skin Manifestations | - |
dc.type | Article | - |
dc.publisher.location | 스위스 | - |
dc.identifier.doi | 10.1159/000331417 | - |
dc.identifier.scopusid | 2-s2.0-80053643861 | - |
dc.identifier.wosid | 000294954600010 | - |
dc.identifier.bibliographicCitation | ONCOLOGY, v.81, no.1, pp 55 - 62 | - |
dc.citation.title | ONCOLOGY | - |
dc.citation.volume | 81 | - |
dc.citation.number | 1 | - |
dc.citation.startPage | 55 | - |
dc.citation.endPage | 62 | - |
dc.description.isOpenAccess | N | - |
dc.description.journalRegisteredClass | sci | - |
dc.description.journalRegisteredClass | scie | - |
dc.description.journalRegisteredClass | scopus | - |
dc.relation.journalResearchArea | Oncology | - |
dc.relation.journalWebOfScienceCategory | Oncology | - |
dc.subject.keywordPlus | CUTANEOUS METASTASES | - |
dc.subject.keywordPlus | LUNG METASTASIS | - |
dc.subject.keywordPlus | RECEPTOR STATUS | - |
dc.subject.keywordPlus | TUMORS | - |
dc.subject.keywordPlus | CLASSIFICATION | - |
dc.subject.keywordPlus | CHEMOTHERAPY | - |
dc.subject.keywordAuthor | Skin changes | - |
dc.subject.keywordAuthor | Soft tissue infiltration | - |
dc.subject.keywordAuthor | Breast cancer | - |
dc.subject.keywordAuthor | Human epidermal growth factor receptor 2 | - |
dc.subject.keywordAuthor | Hormonal receptor | - |
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