Loss of spinal mu-opioid receptor is associated with mechanical allodynia in a rat model of peripheral neuropathy
DC Field | Value | Language |
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dc.contributor.author | Back, Seung Keun | - |
dc.contributor.author | Lee, Jaehee | - |
dc.contributor.author | Hong, Seung Kil | - |
dc.contributor.author | Na, Heung Sik | - |
dc.date.available | 2020-12-09T10:22:49Z | - |
dc.date.issued | 2006-07 | - |
dc.identifier.issn | 0304-3959 | - |
dc.identifier.issn | 1872-6623 | - |
dc.identifier.uri | https://scholarworks.korea.ac.kr/kumedicine/handle/2020.sw.kumedicine/36073 | - |
dc.description.abstract | The present study investigated whether the loss of spinal mu-opioid receptors following peripheral nerve injury is related to mechanical allodynia. We compared the quantity of spinal mu-opioid receptor and the effect of its antagonists, such as naloxone and CTOP, on pain behaviors in two groups of rats that showed extremely different severity of mechanical allodynia 2 weeks following partial injury of tail-innervating nerves. One group (allodynic group) exhibited robust signs of mechanical allodynia after the nerve injury, whereas the other group (non-allodynic group) showed little allodynia despite having suffered the same nerve injury. In addition, we investigated the quantity of spinal p-opioid receptor and the effect of its antagonists on pain behaviors after the rats had recovered from mechanical allodynia, 16 weeks following nerve injury. Immunohistochemical and Western blot analyses at 2 weeks after nerve injury indicated that spinal mu-opioid receptor content was more reduced in the allodynic group compared to the non-allodynic group. Intraperitoneal naloxone (2 mg/kg, i.p.) and intrathecal CTOP (10 mu g/rat, i.t.) administration dramatically induced mechanical allodynia, in the non-allodynic group. However, as in naive animals, neither the loss of spinal mu-opioid receptors nor antagonist-induced mechanical allodynia was observed in the rats that had recovered from mechanical allodynia. These results suggest that the loss of spinal mu-opioid receptors following peripheral nerve injury is related to mechanical allodynia. (c) 2006 International Association for the Study of Pain. Published by Elsevier B.V. All rights reserved. | - |
dc.format.extent | 10 | - |
dc.language | 영어 | - |
dc.language.iso | ENG | - |
dc.publisher | LIPPINCOTT WILLIAMS & WILKINS | - |
dc.title | Loss of spinal mu-opioid receptor is associated with mechanical allodynia in a rat model of peripheral neuropathy | - |
dc.type | Article | - |
dc.publisher.location | 미국 | - |
dc.identifier.doi | 10.1016/j.pain.2006.02.017 | - |
dc.identifier.scopusid | 2-s2.0-33744530178 | - |
dc.identifier.wosid | 000238745800016 | - |
dc.identifier.bibliographicCitation | PAIN, v.123, no.1-2, pp 117 - 126 | - |
dc.citation.title | PAIN | - |
dc.citation.volume | 123 | - |
dc.citation.number | 1-2 | - |
dc.citation.startPage | 117 | - |
dc.citation.endPage | 126 | - |
dc.type.docType | Article | - |
dc.description.isOpenAccess | N | - |
dc.description.journalRegisteredClass | scie | - |
dc.description.journalRegisteredClass | scopus | - |
dc.relation.journalResearchArea | Anesthesiology | - |
dc.relation.journalResearchArea | Neurosciences & Neurology | - |
dc.relation.journalWebOfScienceCategory | Anesthesiology | - |
dc.relation.journalWebOfScienceCategory | Clinical Neurology | - |
dc.relation.journalWebOfScienceCategory | Neurosciences | - |
dc.subject.keywordPlus | SUPERFICIAL DORSAL HORN | - |
dc.subject.keywordPlus | INDUCED TACTILE ALLODYNIA | - |
dc.subject.keywordPlus | PAIN-RELATED BEHAVIORS | - |
dc.subject.keywordPlus | ROOT GANGLION NEURONS | - |
dc.subject.keywordPlus | NERVE INJURY | - |
dc.subject.keywordPlus | PRIMARY AFFERENTS | - |
dc.subject.keywordPlus | GABAERGIC INHIBITION | - |
dc.subject.keywordPlus | SUBSTANCE-P | - |
dc.subject.keywordPlus | LAMINA-II | - |
dc.subject.keywordPlus | CORD | - |
dc.subject.keywordAuthor | neuropathic pain | - |
dc.subject.keywordAuthor | mechanical allodynia | - |
dc.subject.keywordAuthor | peripheral nerve injury | - |
dc.subject.keywordAuthor | spinal mu-opioid receptor | - |
dc.subject.keywordAuthor | naloxone | - |
dc.subject.keywordAuthor | CTOP | - |
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