T-lymphocyte subsets in patients with AJCC stage III gastric cancer during postoperative adjuvant chemotherapy
DC Field | Value | Language |
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dc.contributor.author | Cho M.Y. | - |
dc.contributor.author | Joh Y.G. | - |
dc.contributor.author | Kim N.R. | - |
dc.contributor.author | Jung S.I. | - |
dc.contributor.author | Bae J.W. | - |
dc.contributor.author | Kim Y.C. | - |
dc.contributor.author | Koo B.H. | - |
dc.contributor.author | Whang C.W. | - |
dc.contributor.author | Suh S.O. | - |
dc.date.available | 2020-12-09T11:03:37Z | - |
dc.date.issued | 2002 | - |
dc.identifier.issn | 1457-4969 | - |
dc.identifier.issn | 1799-7267 | - |
dc.identifier.uri | https://scholarworks.korea.ac.kr/kumedicine/handle/2020.sw.kumedicine/37135 | - |
dc.description.abstract | Background and Aims: Advanced neoplastic diseases alter the immune response in cancer patients. The aim of this study was to evaluate the changes of T-lymphocyte subsets during postoperative adjuvant chemotherapy, and the relationship between T-lymphocyte subsets and tumor recurrence in AJCC stage III gastric cancers. Material and Methods: Analysis of T-lymphocyte subsets was performed in 39 patients with stage III gastric adenocarcinoma who had undergone a curative gastric resection and postoperative chemotherapy. Circulating T-lymphocyte subsets were measured on venous blood by using flow cytometry and monoclonal antibodies on preoperative day 1, and postoperative months 1, 3, and 6. Results: The 5-year disease-free survival rates of patients with stage 3a and 3b gastric cancer were 57.1 % and 33.3 %, respectively (p = 0.06). Values of CD3+ and CD4+ T-cells, and CD4+/CD8+ ratios were consistently lower in the recurrence group throughout the observation period. CD4+ T-cell counts were significantly lower in the recurrence group on preoperative day 1, and postoperative months 1 and 6. However, most values of the T-lymphocyte subsets showed no statistically significant difference when comparing the stage 3a and 3b disease patient groups. Conclusions: The results of this study suggest that immunosuppression associated with CD3+ and CD4+ T-cell depression is a risk factor for postoperative recurrence in patients with stage III gastric cancer. | - |
dc.format.extent | 6 | - |
dc.language | 영어 | - |
dc.language.iso | ENG | - |
dc.publisher | Finnish Surgical Society | - |
dc.title | T-lymphocyte subsets in patients with AJCC stage III gastric cancer during postoperative adjuvant chemotherapy | - |
dc.type | Article | - |
dc.publisher.location | 영국 | - |
dc.identifier.doi | 10.1177/145749690209100207 | - |
dc.identifier.scopusid | 2-s2.0-0036368104 | - |
dc.identifier.bibliographicCitation | Scandinavian Journal of Surgery, v.91, no.2, pp 172 - 177 | - |
dc.citation.title | Scandinavian Journal of Surgery | - |
dc.citation.volume | 91 | - |
dc.citation.number | 2 | - |
dc.citation.startPage | 172 | - |
dc.citation.endPage | 177 | - |
dc.type.docType | Article | - |
dc.description.isOpenAccess | N | - |
dc.description.journalRegisteredClass | scopus | - |
dc.subject.keywordPlus | CD4 antigen | - |
dc.subject.keywordPlus | CD8 antigen | - |
dc.subject.keywordPlus | cisplatin | - |
dc.subject.keywordPlus | fluorouracil | - |
dc.subject.keywordPlus | diagnostic agent | - |
dc.subject.keywordPlus | monoclonal antibody | - |
dc.subject.keywordPlus | adult | - |
dc.subject.keywordPlus | aged | - |
dc.subject.keywordPlus | article | - |
dc.subject.keywordPlus | cancer adjuvant therapy | - |
dc.subject.keywordPlus | cancer recurrence | - |
dc.subject.keywordPlus | cancer staging | - |
dc.subject.keywordPlus | cancer surgery | - |
dc.subject.keywordPlus | cancer survival | - |
dc.subject.keywordPlus | clinical article | - |
dc.subject.keywordPlus | controlled study | - |
dc.subject.keywordPlus | female | - |
dc.subject.keywordPlus | flow cytometry | - |
dc.subject.keywordPlus | gastrectomy | - |
dc.subject.keywordPlus | human | - |
dc.subject.keywordPlus | immune response | - |
dc.subject.keywordPlus | immunity | - |
dc.subject.keywordPlus | lymphocyte count | - |
dc.subject.keywordPlus | male | - |
dc.subject.keywordPlus | postoperative care | - |
dc.subject.keywordPlus | preoperative evaluation | - |
dc.subject.keywordPlus | risk factor | - |
dc.subject.keywordPlus | stomach adenocarcinoma | - |
dc.subject.keywordPlus | stomach cancer | - |
dc.subject.keywordPlus | survival rate | - |
dc.subject.keywordPlus | T lymphocyte | - |
dc.subject.keywordPlus | venous blood | - |
dc.subject.keywordPlus | adenocarcinoma | - |
dc.subject.keywordPlus | adjuvant chemotherapy | - |
dc.subject.keywordPlus | analysis of variance | - |
dc.subject.keywordPlus | disease free survival | - |
dc.subject.keywordPlus | immunology | - |
dc.subject.keywordPlus | middle aged | - |
dc.subject.keywordPlus | pathology | - |
dc.subject.keywordPlus | prospective study | - |
dc.subject.keywordPlus | stomach tumor | - |
dc.subject.keywordPlus | T lymphocyte subpopulation | - |
dc.subject.keywordPlus | tumor recurrence | - |
dc.subject.keywordPlus | Adenocarcinoma | - |
dc.subject.keywordPlus | Adult | - |
dc.subject.keywordPlus | Aged | - |
dc.subject.keywordPlus | Aged, 80 and over | - |
dc.subject.keywordPlus | Analysis of Variance | - |
dc.subject.keywordPlus | Antibodies, Monoclonal | - |
dc.subject.keywordPlus | Chemotherapy, Adjuvant | - |
dc.subject.keywordPlus | Disease-Free Survival | - |
dc.subject.keywordPlus | Female | - |
dc.subject.keywordPlus | Flow Cytometry | - |
dc.subject.keywordPlus | Humans | - |
dc.subject.keywordPlus | Male | - |
dc.subject.keywordPlus | Middle Aged | - |
dc.subject.keywordPlus | Neoplasm Recurrence, Local | - |
dc.subject.keywordPlus | Prospective Studies | - |
dc.subject.keywordPlus | Risk Factors | - |
dc.subject.keywordPlus | Stomach Neoplasms | - |
dc.subject.keywordPlus | Survival Rate | - |
dc.subject.keywordPlus | T-Lymphocyte Subsets | - |
dc.subject.keywordAuthor | Immunosuppression | - |
dc.subject.keywordAuthor | Lymphocyte subsets | - |
dc.subject.keywordAuthor | Recurrence | - |
dc.subject.keywordAuthor | Stomach neoplasms | - |
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