Reduced risk of hepatocellular carcinoma by achieving a subcirrhotic liver stiffness through antiviral agents in hepatitis B virus-related advanced fibrosis or cirrhosis
DC Field | Value | Language |
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dc.contributor.author | Kim, Byung Seok | - |
dc.contributor.author | Seo, Yeon Seok | - |
dc.contributor.author | Kim, Young Seok | - |
dc.contributor.author | Lee, Chang Hyeong | - |
dc.contributor.author | Lee, Han Ah | - |
dc.contributor.author | Um, Soon Ho | - |
dc.contributor.author | Yoo, Jeong-Ju | - |
dc.contributor.author | Kim, Sang Gyune | - |
dc.contributor.author | Suh, Sang Jun | - |
dc.contributor.author | Jung, Young Kul | - |
dc.contributor.author | Ahn, Sang Hoon | - |
dc.contributor.author | Han, Kwang-Hyub | - |
dc.contributor.author | Yim, Hyung Joon | - |
dc.contributor.author | Kim, Seung Up | - |
dc.date.available | 2020-11-02T07:47:49Z | - |
dc.date.issued | 2018-02 | - |
dc.identifier.issn | 0815-9319 | - |
dc.identifier.issn | 1440-1746 | - |
dc.identifier.uri | https://scholarworks.korea.ac.kr/kumedicine/handle/2020.sw.kumedicine/3923 | - |
dc.description.abstract | Background and Aim: A subcirrhotic range of liver stiffness (sc-LS), assessed by transient elastography, is associated with better outcomes in patients with chronic hepatitis B (CHB). We investigated whether the achievement of sc-LS by antiviral therapy (AVT) reduced the risk of developing hepatocellular carcinoma (HCC) in patients with CHB-related advanced fibrosis or cirrhosis. Methods: In total, 209 patients with CHB-related advanced fibrosis or cirrhosis, who received paired transient elastography examinations during AVT between 2007 and 2012, were enrolled. The cut-off LS value for ultrasonographic cirrhosis was defined as 11.6 kPa. Results: The median age of the study population was 51years, with males predominating (n=138, 66.0%). The median LS value at enrollment was 14.1kPa (interquartile range: 9.5-24.1 kPa). After 2years of AVT, 140 (67.0%) patients achieved sc-LS. During the study period, 28 (13.4%) patients developed HCC after 2 years of AVT. On multivariate analysis, the achievement of sc-LS after AVT was independently associated with a decreased risk of HCC development (hazard ratio [HR]=0.485, P=0.047), whereas older age (HR=1.071) and male gender (HR=3.704) were independently associated with an increased HCC risk (both P<0.05). Patients with a cirrhotic range of LS value after 2 years of AVT were at a higher risk of HCC development than those with sc-LS (log-rank test, P=0.020). Conclusions: The achievement of sc-LS after AVT can reduce the risk of HCC development in patients with CHB, even when advanced fibrosis or cirrhosis is apparent on starting AVT. | - |
dc.format.extent | 8 | - |
dc.language | 영어 | - |
dc.language.iso | ENG | - |
dc.publisher | WILEY | - |
dc.title | Reduced risk of hepatocellular carcinoma by achieving a subcirrhotic liver stiffness through antiviral agents in hepatitis B virus-related advanced fibrosis or cirrhosis | - |
dc.type | Article | - |
dc.publisher.location | 미국 | - |
dc.identifier.doi | 10.1111/jgh.13854 | - |
dc.identifier.scopusid | 2-s2.0-85041040494 | - |
dc.identifier.wosid | 000423412900028 | - |
dc.identifier.bibliographicCitation | JOURNAL OF GASTROENTEROLOGY AND HEPATOLOGY, v.33, no.2, pp 503 - 510 | - |
dc.citation.title | JOURNAL OF GASTROENTEROLOGY AND HEPATOLOGY | - |
dc.citation.volume | 33 | - |
dc.citation.number | 2 | - |
dc.citation.startPage | 503 | - |
dc.citation.endPage | 510 | - |
dc.type.docType | Article | - |
dc.description.isOpenAccess | Y | - |
dc.description.journalRegisteredClass | sci | - |
dc.description.journalRegisteredClass | scie | - |
dc.description.journalRegisteredClass | scopus | - |
dc.relation.journalResearchArea | Gastroenterology & Hepatology | - |
dc.relation.journalWebOfScienceCategory | Gastroenterology & Hepatology | - |
dc.subject.keywordPlus | CHRONIC VIRAL-HEPATITIS | - |
dc.subject.keywordPlus | TRANSIENT ELASTOGRAPHY | - |
dc.subject.keywordPlus | NONINVASIVE TESTS | - |
dc.subject.keywordPlus | THERAPY | - |
dc.subject.keywordPlus | REGRESSION | - |
dc.subject.keywordPlus | BIOPSY | - |
dc.subject.keywordPlus | MANAGEMENT | - |
dc.subject.keywordPlus | INFECTION | - |
dc.subject.keywordPlus | ACCURACY | - |
dc.subject.keywordAuthor | antiviral therapy | - |
dc.subject.keywordAuthor | cirrhosis | - |
dc.subject.keywordAuthor | hepatitis B | - |
dc.subject.keywordAuthor | hepatocellular carcinoma | - |
dc.subject.keywordAuthor | liver fibrosis | - |
dc.subject.keywordAuthor | liver stiffness | - |
dc.subject.keywordAuthor | transient elastography | - |
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