Clinicopathologic Study of Biliary Intraepithelial Neoplasia in Cholangiocarcinoma
DC Field | Value | Language |
---|---|---|
dc.contributor.author | Kim, Hyo Jung | - |
dc.contributor.author | Kim, Jae Seon | - |
dc.contributor.author | Kim, Baek Hee | - |
dc.contributor.author | Bak, Young-Tae | - |
dc.date.available | 2020-11-02T08:01:56Z | - |
dc.date.issued | 2018 | - |
dc.identifier.issn | 0253-4886 | - |
dc.identifier.issn | 1421-9883 | - |
dc.identifier.uri | https://scholarworks.korea.ac.kr/kumedicine/handle/2020.sw.kumedicine/4274 | - |
dc.description.abstract | Backgrounds and Aims: Biliary intraepithelial neoplasia (BilIN) is a precursor of cholangiocarcinoma (CC) and it has been associated with several chronic inflammatory conditions. This study aimed to elucidate the prevalence of BilIN in CC and its clinicopathological significance. Methods: Medical records of 193 patients with histologically confirmed CC were analyzed. We reviewed the pathology findings of 48 patients who underwent curative surgery for CC. Results: Of the 48 patients analyzed, 34 and 14 patients had extrahepatic and intrahepatic CC respectively. BilIN was detected in 28 patients (58%) and showed a significantly higher prevalence in extrahepatic CC (75%) than in intrahepatic CC (21%; p < 0.001). In the subgroup of 34 patients with extrahepatic CC, 25 and 9 patients were BilIN positive and negative respectively. Poor differentiation and T3 stage were significantly more common in the BilIN-negative group than in the BilIN-positive group (p < 0.05). The expression of MUC5AC, p53, and loss of Smad4 showed no difference between BilIN-positive CC and in BilIN-negative CC, but the Ki-67 expression was significantly higher (p < 0.05). Conclusion: BilIN-positive CC showed less invasiveness than negative cases. The Ki-67 expression was significantly higher in BilIN-positive CC. (C) 2017 S. Karger AG, Basel | - |
dc.format.extent | 5 | - |
dc.language | 영어 | - |
dc.language.iso | ENG | - |
dc.publisher | KARGER | - |
dc.title | Clinicopathologic Study of Biliary Intraepithelial Neoplasia in Cholangiocarcinoma | - |
dc.type | Article | - |
dc.publisher.location | 스위스 | - |
dc.identifier.doi | 10.1159/000475848 | - |
dc.identifier.scopusid | 2-s2.0-85018886949 | - |
dc.identifier.wosid | 000431541100004 | - |
dc.identifier.bibliographicCitation | DIGESTIVE SURGERY, v.35, no.2, pp 116 - 120 | - |
dc.citation.title | DIGESTIVE SURGERY | - |
dc.citation.volume | 35 | - |
dc.citation.number | 2 | - |
dc.citation.startPage | 116 | - |
dc.citation.endPage | 120 | - |
dc.type.docType | Article | - |
dc.description.isOpenAccess | N | - |
dc.description.journalRegisteredClass | scie | - |
dc.description.journalRegisteredClass | scopus | - |
dc.relation.journalResearchArea | Gastroenterology & Hepatology | - |
dc.relation.journalResearchArea | Surgery | - |
dc.relation.journalWebOfScienceCategory | Gastroenterology & Hepatology | - |
dc.relation.journalWebOfScienceCategory | Surgery | - |
dc.subject.keywordPlus | INTRAHEPATIC CHOLANGIOCARCINOMA | - |
dc.subject.keywordPlus | BILE-DUCT | - |
dc.subject.keywordPlus | INTEROBSERVER AGREEMENT | - |
dc.subject.keywordPlus | EPITHELIAL LESIONS | - |
dc.subject.keywordPlus | HEPATOLITHIASIS | - |
dc.subject.keywordPlus | TRACT | - |
dc.subject.keywordPlus | CRITERIA | - |
dc.subject.keywordPlus | PROPOSAL | - |
dc.subject.keywordAuthor | Biliary intraepithelial neoplasia | - |
dc.subject.keywordAuthor | Cholangiocarcinoma | - |
dc.subject.keywordAuthor | Ki-67 | - |
Items in ScholarWorks are protected by copyright, with all rights reserved, unless otherwise indicated.
73, Goryeodae-ro, Seongbuk-gu, Seoul, Republic of Korea (02841)82-2-2286-1265
COPYRIGHT 2020 KOREA UNIVERSITY MEDICAL LIBRARY ALL RIGHTS RESERVED.
Certain data included herein are derived from the © Web of Science of Clarivate Analytics. All rights reserved.
You may not copy or re-distribute this material in whole or in part without the prior written consent of Clarivate Analytics.